I’ve touched upon this before, and it’s only speculation – but I think Liz lead an extremely sheltered life with Macho.
When she was finally free of it, well…think of it as how some kids behave when they finally go away to college – only Liz was involved in/had access to more serious stuff.
Don't forget that Luger was no saint back then, either.
Liz now had an all access pass to a wilder life – a life she’d never experienced – and, like a lot of people, she O.D.’d (no pun intended) on it.
Maybe she was overprotected with Savage, but at least she was safe(r) from the kind of stuff that ultimately did her in.