This is true and is why it is recommended for PCT. The best AI you can use in combination with clomid or nolva during PCT. While on cycle your levels will more than likely be off anyways, which is why Adex is best, Adex won't remove to much estro when used correctly, just enough to control levels. Letro will kill your estradiol levels and this will cause you problems. Unless you have stuborn gyno, or are prepping for a contest stay away from letro. When used to treat gyno stop using after gyno has subsided and go back to adex.