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Insulin Resistance as a Predictor of Age-Related Diseases

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loco:
"This study was initiated to evaluate the hypothesis that insulin resistance would predict the development, over time, of clinical syndrome that might be best subsumed under the heading of age-related diseases (HT, CHD, stroke, cancer, and type 2 diabetes). Although the results provide substantial support for this point of view, perhaps the most striking finding was that none of these events were seen in the third of the population that was most insulin-sensitive. Given the fact that the period of observation ranged from 4–11 yr, with an average follow-up of 6.3 yr, the fact that not one clinical event took place in the insulin-sensitive tertile seems to be truly remarkable. If the ability of insulin sensitivity to decrease risk of developing age-related diseases can be confirmed in subsequent studies, the public health implications are enormous.

Thus, in the case of cancer, it could be argued that the more appropriate conclusion is that insulin sensitivity decreases cancer risk, rather than insulin resistance increasing it. The fact that we cannot differentiate between these two alternatives at this time does not negate the potential importance of our findings nor the need to pursue this issue more vigorously.

In conclusion, an age-related disease developed in approximately one out of three healthy individuals who were in the upper tertile of insulin resistance at baseline, followed for an average of 6 yr. In contrast, no clinical event was seen in the most insulin-sensitive tertile. These data should serve as a strong stimulus for further efforts to define the role of insulin resistance in the genesis of age-related diseases."

The number of clinical events observed, as a function of insulin resistance tertile at baseline.



CVA: cerebrovascular accident
Type 2: type 2 diabetes
CHD: coronary heart disease
CA: cancer
HT: hypertension

https://academic.oup.com/jcem/article/86/8/3574/2848584



"Ketogenic diets improve insulin sensitivity through their irrefutable effects on fat and weight loss. Besides weight loss, KD produce direct insulin-sensitizing effects which are mostly due to the capacity of its restricted-digestible carbohydrates content to lower blood glucose and insulin levels. In addition, ketone bodies appear to be able to influence insulin signaling directly."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385501/

bhank:
https://pubmed.ncbi.nlm.nih.gov/23684393/

ProudVirgin69:
Insulin resistance is associated with increased incidence of disease??  Wow.  I didn’t know that.  You’re telling me now for the first time.

loco:

--- Quote from: ProudVirgin69 on April 16, 2024, 04:22:54 AM ---Insulin resistance is associated with increased incidence of disease??  Wow.  I didn’t know that.  You’re telling me now for the first time.

--- End quote ---

Not only that:

"the most striking finding was that none of these events were seen in the third of the population that was most insulin-sensitive."

"the fact that not one clinical event took place in the insulin-sensitive tertile seems to be truly remarkable."

"insulin sensitivity decreases cancer risk"

kreator:
Eat vegetables every day -   ::)

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