Really?
Hmmm...my pop's buddy hunts hogs with his Smith & Wesson model 500 revolver.
The .600 nitro express is used for big game hunting in Africa like elephants and water buffalo...etc.
Your .45 isn't gonna do anything more than to piss off a big animal.
The .50 cal is used in the military & .50 BMG round is used by snipers as well.
What kind of idiot would hunt big game with a handgun !?!? that's rifle category, I really don't think you'd want to get close enough to a water buffalo for a handgun to be effective, when you could easily pick him off from a few hundred yards.
But hey, to each their own
bottom line is most people can't handle the kickback/recoil from anything over a .45, I got pushed about a foot and a half back when I was shooting the Desert Eagle .50 cal in vegas, and at the time I was a juiced up 260lbs.