Borderline Personality Disorder Brain and Gene Function Mapped by New Research
Newswise — Mount Sinai researchers have found that real-time brain imaging suggests that patients with Borderline Personality Disorder (BPD) are physically unable to activate neurological networks that can help regulate emotion. The findings, by Harold W. Koenigsberg, MD, Professor of Psychiatry at Mount Sinai School of Medicine, were presented at the 11th International Congress of the International Society for the Study of Personality Disorders (ISSPD), held August 21 – 23 at The Mount Sinai Medical Center in New York. The research will also be published in the journal Biological Psychiatry.
Using functional magnetic resonance imaging (MRI), Dr. Koenigsberg observed how the brains of people with BPD reacted to social and emotional stimuli. He found that when people with BPD attempted to control and reduce their reactions to disturbing emotional scenes, the anterior cingulated cortex and intraparetical sulci areas of the brain that are active in healthy people under the same conditions remained inactive in the BPD patients.
“This research shows that BPD patients are not able to use those parts of the brain that healthy people use to help regulate their emotions,” said Dr. Koenigsberg. “This may explain why their emotional reactions are so extreme. The biological underpinnings of the disordered emotional control systems are central to borderline pathology. Studying which areas of the brain function differently in patients with borderline personality disorder can lead to more targeted uses of psychotherapy and medications, and also provide a link to connect the genetic basis of the disorder.”
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