OK, I'm a little more confused than I normally am. 3 - 4k calories daily and you weigh 165? What, do you walk to work every day... 32 miles? Each way?
Clean diet and it obviously works for you and that's one of the hardest things for cats to figure out... what works for you.
Occupational NEAT perhaps.
NON-EXERCISE ACTIVITY THERMOGENESISIntroduction
Looking out over this crowded coffee bar, I see a 40-year-old man reading a newspaper. He is stationary. He sits next to a 30-year-old woman. She can barely sit still. She gets up and curves between the tightly squeezed tables, just to get a napkin and then gesticulates wildly as she talks on her cell phone. He has still not moved. He thinks now of his three-year-old daughter at home; "she just never stops" he thinks. He smiles to himself and scratches his nose. She gesticulates further as she tells a friend of a rat she saw scuttling rapidly on the subway rails. A taxi drives by. The driver immigrated from an agricultural community in the Ivory Coast. Birds soar high over-head. All these living beings exhibit spontaneous physical activity or, Non-exercise Activity Thermogenesis (NEAT).
Human Energy Expenditure (and semantics)
Even lean individuals store at least two to three months of their energy needs in adipose tissue whereas obese persons can carry a year's worth of their energy needs. It is the cumulative impact of energy imbalance over months and years that results in the development of obesity or undernutrition.
There are three principal components of human energy expenditure (EE), basal metabolic rate (BMR), thermic effect of food (TEF) and activity thermogenesis. There are also other small components of EE that may contribute to the whole, such as the energetic costs of medications and emotion.
BMR is the energy expended when an individual is laying at complete rest, in the morning, after sleep, in the postabsorptive state. In individuals with sedentary occupations BMR accounts for approximately 60 percent of total daily EE. Three-quarter's of the variability in BMR is predicted by lean body mass within and across species. TEF is the increase in EE associated with the digestion, absorption, and storage of food and accounts for approximately 10-15 percent of total daily EE.
Activity Thermogenesis has two constituents, exercise-related activity thermogenesis and Non-exercise Activity Thermogenesis (NEAT). For the vast majority of dwellers in the U.S., exercise activity thermogenesis is negligible. NEAT, even in avid exercisers, is the predominant constituent of activity thermogenesis and is the EE associated with all the activities we undertake as vibrant, independent beings. NEAT has an enormous variety of constituents including occupation, leisure and fidgeting. Because of this, NEAT is challenging to study and its role in human energy balance has been difficult to define.
Non-exercise Activity Thermogenesis (NEAT)
NEAT is likely to contribute substantially to the inter- and intra-personal variability in EE. Argue thus; if three-quarters of the variance of BMR is accounted for by variance in lean body mass and, TEF represents 10-15 percent of total EE, then the majority of the variance in total EE that occurs independent of body weight must be accounted for by NEAT. Evidence supports this. NEAT is highly variable and ranges from ~ 15 percent of total daily EE in very sedentary individuals to >50 percent in highly active persons . Even minor changes in physical activity throughout the day can increase daily EE by 20 percent. NEAT is impacted by environment, but is also under biological control .
NEAT and environment
There are many environmental cues that impact NEAT. Broadly, they can be divided into occupational and non-occupational components.
NEAT and occupation
Matched individuals with highly active ambulatory jobs can have NEAT values of 1000 kcal/day greater than sedentary peers. In areas of nutritional need, this has implications for starvation-threatened individuals. In affluent countries, industrialized can convert high-NEAT jobs to lower-NEAT jobs and this has been associated with increased obesity rates.
Non-occupation NEAT
* Dish washers
* Cars
* Remotes
* Lawnmowers
* Drive-through
* Game-boy
* Elevators
* Snow blowers
Leisure-time sedentariness has resulted from the availability and volitional use of pervasive mechanization. When the energetic cost of non-work mechanization is estimated experimentally it approximates to, 100-200 kcal/day; a caloric deficit that potentially could account for the entire obesity epidemic.
NEAT and physiology
With experimental overfeeding in humans, NEAT increases. Those who increased their NEAT the most with overfeeding gained the least fat. This suggests that along with self-evident societal slothfulness, NEAT is biologically modulated. Animal data support this. There appear to be central mediators of NEAT. For example, microinjections of orexins into hypothalamic nuclei increase NEAT whereas antagonists decrease it. There may be humoral mediators as experimental hyperthyroidism is associated with increased NEAT. There also be genetic mechanism at play; during overfeeding twinness in part predicts fat gain. Also NEAT is specific for different genetic strains of mice.
Where to from here?
Mechanism: by understanding the neuromodulators and non-central mediators of NEAT; its biological function will become clear.
Physiology: What are the key components of NEAT? What is the role of NEAT in aging, children, gender, and race? How does positive and negative affect NEAT and its components?
Pathology: What is the role of NEAT in obesity and eating disorders?
Intervention: Targeted, evaluated interventions from person to population.
