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Getbig Main Boards => Gossip & Opinions => Topic started by: Army of One on September 10, 2012, 04:13:45 AM

Title: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Army of One on September 10, 2012, 04:13:45 AM
Reading mixed reports on the interwebz, anyone have a more conclusive answer?
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: BigCyp on September 10, 2012, 04:18:31 AM
Yes it's ok, but you have to take it all at once with 5 red bulls. Make sure that noone knows where you are, and your phone is out of battery this will help to maximise the fat loss potential
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Army of One on September 10, 2012, 04:56:31 AM
Yes it's ok, but you have to take it all at once with 5 red bulls. Make sure that noone knows where you are, and your phone is out of battery this will help to maximise the fat loss potential

Derek Anthony, is that you?
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Moen on September 10, 2012, 05:01:17 AM
Reading mixed reports on the interwebz, anyone have a more conclusive answer?

It is safe. I did so with high dose amphetamine, mdma and cocaine even. No problem. Ephedrine is not even serotonergic so there is no danger at all.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: BigCyp on September 10, 2012, 05:01:26 AM
Derek Anthony, is that you?

Hahaha
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: bigmikecox on September 10, 2012, 09:02:32 AM
Ive taken it with nubain so you should be ok
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Luolamies on September 10, 2012, 09:38:32 AM
Reading mixed reports on the interwebz, anyone have a more conclusive answer?

Yes, it's OK.

No serious negative interactions.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Necrosis on September 10, 2012, 10:50:57 AM
Reading mixed reports on the interwebz, anyone have a more conclusive answer?

well Venalfaxine has NRI acitvity and ephedrine is a non-selective beta agonist sympathomimetic, does that answer teh question?
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: mass243 on September 10, 2012, 10:55:34 AM


I would seriously consider consulting Dr. Dutch before taking any substances.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Van_Bilderass on September 10, 2012, 11:00:04 AM
It is safe. I did so with high dose amphetamine, mdma and cocaine even. No problem. Ephedrine is not even serotonergic so there is no danger at all.

I will probably never do these narcotics, but I'm still curious... did you get any effect from the MDMA?

One friend said amphetamines go great with venlafaxine because there is no "hangover"... you don't feel shitty coming off the speed.

As far as the OP question, I'm sure there's an increased risk for seizures... and high BP, etc. But I've done a ton of ephedrine on Effexor and haven't had any seizures.

Ive taken it with nubain so you should be ok

Ephedrine and Nubain are two completely different drugs so I'm not sure how you're reasoning here.  :D
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Moen on September 10, 2012, 11:28:10 AM
I will probably never do these narcotics, but I'm still curious... did you get any effect from the MDMA?

Much less than when not on Effexor idd

One friend said amphetamines go great with venlafaxine because there is no "hangover"... you don't feel shitty coming off the speed.

Maybe less but no is a bit of a stretch, I don't think you can avoid this entirely, no matter what you do or take

As far as the OP question, I'm sure there's an increased risk for seizures... and high BP, etc. But I've done a ton of ephedrine on Effexor and haven't had any seizures.

Ephedrine and Nubain are two completely different drugs so I'm not sure how you're reasoning here.  :D

I think the Serotonin elevation you'd normally get is blocked, and on an SNRI the Norepinephrine elevation as well. That leaves you with the dopamine effect which you still feel of course.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Princess L on September 10, 2012, 12:41:20 PM
Reading mixed reports on the interwebz, anyone have a more conclusive answer?

The government has already told you ephedrine is not safe.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Necrosis on September 10, 2012, 12:44:19 PM
I will probably never do these narcotics, but I'm still curious... did you get any effect from the MDMA?

One friend said amphetamines go great with venlafaxine because there is no "hangover"... you don't feel shitty coming off the speed.

As far as the OP question, I'm sure there's an increased risk for seizures... and high BP, etc. But I've done a ton of ephedrine on Effexor and haven't had any seizures.

Ephedrine and Nubain are two completely different drugs so I'm not sure how you're reasoning here.  :D

what about when you are asleep? any seizures then? how can you be so sure?
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: El Diablo Blanco on September 10, 2012, 12:45:41 PM
You never know until you try
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: The Wizard of Truth on September 10, 2012, 01:32:50 PM
It didn't kill me anyway
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Big Chiro Flex on September 10, 2012, 01:45:44 PM
The government has already told you ephedrine is not safe.
Is this post trolling?

Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: bigmikecox on September 10, 2012, 01:49:10 PM
The government has already told you ephedrine is not safe.

Love havinig white, senior citizens making choices on what I put in MY body!
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: booty on September 10, 2012, 02:14:45 PM
Is this post trolling?


No it's sarcasm. 
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Big Chiro Flex on September 10, 2012, 02:34:15 PM
No it's sarcasm. 
Stop flirting with me, you know my guard is up with you and I'm scared of falling in e-love.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: chaos on September 10, 2012, 08:10:48 PM
Stop flirting with me, you know my guard is up with you and I'm scared of falling in e-love.
Go for it, getbig needs the humor. :D
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: 240 is Back on September 10, 2012, 08:14:52 PM
Yes it's ok, but you have to take it all at once with 5 red bulls. Make sure that noone knows where you are, and your phone is out of battery this will help to maximise the fat loss potential

hahaha that's just evil!  hahahaha
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Van_Bilderass on September 11, 2012, 04:19:16 AM
what about when you are asleep? any seizures then? how can you be so sure?

Well, what's to say anyone doesn't have nightly seizures on Effexor even without ephedrine, since apparently there are no signs or symptoms?


Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Army of One on September 11, 2012, 05:38:46 AM
From another forum


I'm certainly glad to hear that you haven't had any major health consequences of mixing EC and Pristiq yet. Unfortunately, that doesn't mean that you're in the clear, and here's why. Pristiq is an SNRI, or Serotonin and Norepinephrine Reuptake Inhibitor. It increases the serotonin and norepinephrine input to your nervous system (specifically, each time those two chemicals get released to stimulate a neuron, it blocks the body's enzymes that break them down, making the signals last longer). Ephedrine's effects are more numerous and less well understood, but we know that among them it enhances the release of norepinephrine and increases the activity of norepinephrine receptors. By combining these drugs, you end up flooding your neurons with norepinephrine and disabling the body's ability to wash it out. Marinating your nervous system in adrenaline can be a bad thing acutely because it can kill you (unrestrained hypertension with stroke or cerebral aneurysm, sudden cardiac death, etc). However, it can also be dangerous chronically, because keeping your body in the stressed fight or flight state can cause slow, silent damage to your heart and circulatory system (specifically myocardial necrosis and valvular damage, potentially but not necessarily leading to congestive heart failure aka inability of the heart to adequately pump blood), which only makes itself known to you when the heart can finally no longer compensate for all its chronic injury.

Additionally, taking both of these drugs together puts you at an increased risk for cardiac arrhythmia (again, because of the massive excess of norepinephrine activity). Arrhythmia is something that does not necessarily produce any physical symptoms and is also something that can come and go at will. My point being, unless you have your finger on your pulse all day (and even then, because the disturbance in heart rhythm is often subtle and hard to pick out), the drugs may be moving you in and out on normal cardiac rhythm without you even noticing. This is problematic because the 'benign' asymptomatic arrhythmias can sometimes transform into life threatening/ending rhythms, but also because they mess with the blood flow through the heart and increase your risk of forming clots in the heart, which can then travel up your carotid arteries and block off the blood flow your brain, causing a stroke.

In summary, I'm afraid the answer to your question is no. It's entirely possible to take Ephedrine and Pristiq for months or even years without noticing any unusual symptoms, and then end up suffering a heart attack, stroke, sudden death, etc. It's also possible that you may be slowly developing injury that will lead to long term health issues such as heart failure in the future, and that you've yet to notice because your heart hasn't become sufficiently injured to start producing symptoms.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: BigCyp on September 11, 2012, 05:57:43 AM
From another forum


I'm certainly glad to hear that you haven't had any major health consequences of mixing EC and Pristiq yet. Unfortunately, that doesn't mean that you're in the clear, and here's why. Pristiq is an SNRI, or Serotonin and Norepinephrine Reuptake Inhibitor. It increases the serotonin and norepinephrine input to your nervous system (specifically, each time those two chemicals get released to stimulate a neuron, it blocks the body's enzymes that break them down, making the signals last longer). Ephedrine's effects are more numerous and less well understood, but we know that among them it enhances the release of norepinephrine and increases the activity of norepinephrine receptors. By combining these drugs, you end up flooding your neurons with norepinephrine and disabling the body's ability to wash it out. Marinating your nervous system in adrenaline can be a bad thing acutely because it can kill you (unrestrained hypertension with stroke or cerebral aneurysm, sudden cardiac death, etc). However, it can also be dangerous chronically, because keeping your body in the stressed fight or flight state can cause slow, silent damage to your heart and circulatory system (specifically myocardial necrosis and valvular damage, potentially but not necessarily leading to congestive heart failure aka inability of the heart to adequately pump blood), which only makes itself known to you when the heart can finally no longer compensate for all its chronic injury.

Additionally, taking both of these drugs together puts you at an increased risk for cardiac arrhythmia (again, because of the massive excess of norepinephrine activity). Arrhythmia is something that does not necessarily produce any physical symptoms and is also something that can come and go at will. My point being, unless you have your finger on your pulse all day (and even then, because the disturbance in heart rhythm is often subtle and hard to pick out), the drugs may be moving you in and out on normal cardiac rhythm without you even noticing. This is problematic because the 'benign' asymptomatic arrhythmias can sometimes transform into life threatening/ending rhythms, but also because they mess with the blood flow through the heart and increase your risk of forming clots in the heart, which can then travel up your carotid arteries and block off the blood flow your brain, causing a stroke.

In summary, I'm afraid the answer to your question is no. It's entirely possible to take Ephedrine and Pristiq for months or even years without noticing any unusual symptoms, and then end up suffering a heart attack, stroke, sudden death, etc. It's also possible that you may be slowly developing injury that will lead to long term health issues such as heart failure in the future, and that you've yet to notice because your heart hasn't become sufficiently injured to start producing symptoms.

Pffft what do they know anyway.
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: booty on September 11, 2012, 06:19:53 AM
Stop flirting with me, you know my guard is up with you and I'm scared of falling in e-love.

Just don't look into my eyes and you will be fine.   :P
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: Big Chiro Flex on September 11, 2012, 07:58:32 AM
Just don't look into my eyes and you will be fine.   :P
Where's Bike Nut, I need back up here!  :D
Title: Re: Can any docs tell me if its safe to take ephedrine with an SNRI (effexor)?
Post by: IrishMuscle84 on September 11, 2012, 09:17:49 AM
Reading mixed reports on the interwebz, anyone have a more conclusive answer?
Why are you on the Effexor??