Myostatin isn't going to immediately, 100% halt all gains and make training on gear absolutely worthless. We're not dealing with polar extremities. Sure, it's very limiting... but what about the newly acquired mass? Come off all androgens and lose most of it, if not all of it?
Some important factors are the doses, compounds, goals for that particular cycle, cycle history, etc... I think it's good to do small, heavier cycles or blast and cruise for a longer period of time. They both have their pros and cons.