After Raw this past Monday, Taker is surely the favourite again now. It would be a brutal idea to have Lesnar break the streak - win, lose or draw he is as over as he needs to be. IF the streak is ever to be broken, it should be by somebody who is being primed for a major push.
Personally, I hope Taker retires with a perfect record but something tells me he will lose his last Mania match (hopefully not against Cena)