Author Topic: Forskolin As A Tyrosine Hydroxylase Inducer: Potentially Alzheimer's Inducing?  (Read 4343 times)

CigaretteMan

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  Hey. I am coming off a long term stimulant use, and want to avoid the dopaminergic crash. So I was looking for substances to help me. Unfortunately, all the options seem terrible. I was looking into catechol-o-methyltransferase inhibitors, like entecapone and tolcapone, but they are extremely hepatotoxic and are associated with cardiac arrest. Selective MAO-b inhibitors like selegiline and rasagiline are better options, but they have their problems, like the metabolite of selegiline being a neurotoxin, and there is always a risk of hypertensive crisis even with selective MAOIs from them losing selectivity.

  I also looked for natural stuff, but they are comkplete shit. Most of the supposed MAOIs from plants, except for harmala alkaloids, are so weak and have terrible bioavailability. Most are polyphenols, and polyphenols are absolute shit when it comes to bioavailability.

  However, I found one stuff that might work: forskolin. Forskolin seems to increase tyrosine hydroxylase, which is the enzyme that transforms tyrosine into l-dopa, which in turn gets converted into dopamine. Forskolin is a potent adenylate cyclase induder. By inducing adenylate cyclase, forskolin increases cyclic adenosine monophosphate, which in turn induces tyrosine hydroxylase by increasing phosphorylation. See here: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwjOwtaOuo_gAhXDJbkGHXrcAboQFjAAegQIARAB&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F9137913&usg=AOvVaw0cQVS-NJwyRgttquhPUTXP However, unfortunately, the increased Camp also phosphorylates a bunch of other proteins, including the Tau proteins that are responsible for Alzheimer's Disease. See here: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwjV1MrBuo_gAhW2ErkGHRfeBLcQFjAAegQIABAB&url=https%3A%2F%2Fwww.alzheimersanddementia.com%2Farticle%2FS1552-5260(09)00928-5%2Fabstract&usg=AOvVaw3Pc9Uhvh55MvEps8OOks93

  So forskolin might significantly accelerate the degenerative processes in the brain that results in Alzheimer's. My question is: is there something else that is effective at inducing tyrosine hydroxylase selectively? Or maybe something else that inhibits COMT without the serious toxicity of entecapone and tolcapone? Thanks.

Princess L

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  Hey. I am coming off a long term stimulant use, and want to avoid the dopaminergic crash. So I was looking for substances to help me. Unfortunately, all the options seem terrible. I was looking into catechol-o-methyltransferase inhibitors, like entecapone and tolcapone, but they are extremely hepatotoxic and are associated with cardiac arrest. Selective MAO-b inhibitors like selegiline and rasagiline are better options, but they have their problems, like the metabolite of selegiline being a neurotoxin, and there is always a risk of hypertensive crisis even with selective MAOIs from them losing selectivity.

  I also looked for natural stuff, but they are comkplete shit. Most of the supposed MAOIs from plants, except for harmala alkaloids, are so weak and have terrible bioavailability. Most are polyphenols, and polyphenols are absolute shit when it comes to bioavailability.

  However, I found one stuff that might work: forskolin. Forskolin seems to increase tyrosine hydroxylase, which is the enzyme that transforms tyrosine into l-dopa, which in turn gets converted into dopamine. Forskolin is a potent adenylate cyclase induder. By inducing adenylate cyclase, forskolin increases cyclic adenosine monophosphate, which in turn induces tyrosine hydroxylase by increasing phosphorylation. See here: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwjOwtaOuo_gAhXDJbkGHXrcAboQFjAAegQIARAB&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F9137913&usg=AOvVaw0cQVS-NJwyRgttquhPUTXP However, unfortunately, the increased Camp also phosphorylates a bunch of other proteins, including the Tau proteins that are responsible for Alzheimer's Disease. See here: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwjV1MrBuo_gAhW2ErkGHRfeBLcQFjAAegQIABAB&url=https%3A%2F%2Fwww.alzheimersanddementia.com%2Farticle%2FS1552-5260(09)00928-5%2Fabstract&usg=AOvVaw3Pc9Uhvh55MvEps8OOks93

  So forskolin might significantly accelerate the degenerative processes in the brain that results in Alzheimer's. My question is: is there something else that is effective at inducing tyrosine hydroxylase selectively? Or maybe something else that inhibits COMT without the serious toxicity of entecapone and tolcapone? Thanks.


7 years is a long time


http://www.getbig.com/boards/index.php?topic=410442.0
:

CigaretteMan

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7 years is a long time


http://www.getbig.com/boards/index.php?topic=410442.0

  i think you are trolling me...i find your behavior quite unbecoming of a moderator I must say...