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Gossip & Opinions / Re: DEA moves to reschedule cannabis
« Last post by Krankenstein on Today at 05:33:04 AM »People who use marijuana are not drug addicts. Its funny you guys call me a junky because I use cannabis a plant then start confessing to a dozen different weird lab created drugs you guys all take for anxiety depression sleep etc etc
Marijuana dependence occurs when the brain adapts to large amounts of the drug by reducing production of and sensitivity to its own endocannabinoid neurotransmitters
Marijuana use disorder becomes addiction when the person cannot stop using the drug even though it interferes with many aspects of his or her life. Estimates of the number of people addicted to marijuana are controversial, in part because epidemiological studies of substance use often use dependence as a proxy for addiction even though it is possible to be dependent without being addicted. Those studies suggest that 9% of people who use marijuana will become dependent on it rising to about 17% in those who start using in their teens.
Rotter A, Bayerlein K, Hansbauer M, et al. CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. Eur Addict Res. 2013;19(1):13-20. doi:10.1159/000338642
Morgan CJA, Page E, Schaefer C, et al. Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. Br J Psychiatry J Ment Sci. 2013;202(5):381-382. doi:10.1192/bjp.bp.112.121178