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Getbig Bodybuilding Boards => Nutrition, Products & Supplements Info => Topic started by: loco on September 02, 2010, 07:34:55 AM
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by David Mendosa
Monday, August 23, 2010
Vitamin D seems to prevent many of our ills. Some studies show that taking large doses of it will treat just about everything from building strong bones to protecting us from strokes and heart failure to reducing our risk of cancer and on to helping us regulate our immune system and control inflammation, our blood pressure, and even our blood glucose. Higher levels of vitamin D is associated with reduced risks for multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.
Reports of the value of vitamin D for preventing even more conditions continue to appear regularly. Low levels of vitamin D are associated with poor lung function among children with asthma, leading them to use more medication to treat it, as the Journal of Allergy and Clinical Immunology recently reported. Vitamin D might treat or prevent allergy to a common mold that can complicate asthma and frequently affects patients with cystic fibrosis, according to a study that the Journal of Clinical Investigation published a few days ago.
As I wrote here last year we nevertheless might have good reason to wonder if all the current hype over vitamin D is nothing more than a resurgence of snake oil claims.
How could just getting out into the sun more or taking just one inexpensive and tiny pill each day work such magic? It seems to be too good to be true. It doesn’t seem to pass the smell test.
Yet we already had a hint to the solution of this major nutritional puzzle when we learned that what we call “vitamin D” isn’t really a vitamin. When scientists discovered vitamin D in the 1920s and 1930s it seemed to work like a vitamin, so that’s what the called it.
“We have confirmed with our recent research that vitamin D isn’t a vitamin at all,” says Professor Trevor Marshall of the school of biological sciences and biotechnology at Murdoch University in Western Australia. It’s a hormone that is made by the body itself.”
And today the other shoe dropped. Several days ago the Wellcome Trust sent me under embargo the advance word on the latest study that journalists could print this evening. The Wellcome Trust is a global charity headquarters in Britain dedicated to improvements in human and animal health.
The main conclusion of this study goes a long way to explaining why vitamin D seems to work its magic throughout our bodies. The journal Genome Research will publish a study led by Sreeram Ramagopalan and Andreas Heger at the University of Oxford.
Using new DNA sequencing technology, they identified more than 200 genes that vitamin D directly influences and created a map of vitamin D receptor binding across the genome. Vitamin D attaches itself to DNA, thus influencing what proteins we make from our genetic code byactivating this receptor.
The researchers discovered 2,776 binding sites for the vitamin D receptor along the length of the genome. These were unusually concentrated near a number of genes associated with susceptibility to autoimmune conditions and to certain cancers. They also found that vitamin D had a significant effect on the activity of 229 genes including PTPN2, associated with Crohn’s disease and type 1 diabetes.
“Vitamin D status is potentially one of the most powerful selective pressures on the genome in relatively recent times,” says Professor George Ebers of the University of Oxford and one of the senior authors of the paper. “Our study appears to support this interpretation and it may be we have not had enough time to make all the adaptations we have needed to cope with our northern circumstances.”
Seldom does basic science like this make the headlines. But this research certainly warrants that. If vitamin D is snake oil, I’ll drink it.
http://www.healthcentral.com/diabetes/c/17/118406/vitamin-isn-snake
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bump!
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i tak a LOT of D3....
bench
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i tak a LOT of D3....
bench
How many i.u.?
I think i am at about 3000.
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You should check out the political boards where many not funny Obama created every problem in the world threads are made every day.
This is the nutrition board, and the thread is about Vit D.
Pardon my french, but please fuck off to the politics board then. :-* :-* ;D
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How many i.u.?
I think i am at about 3000.
I believe the upper limit is 2000. Not sure what the downside/upside is to more :-\
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I believe the upper limit is 2000. Not sure what the downside/upside is to more :-\
Oh, that's long gone, actually.
http://en.wikipedia.org/wiki/Hypervitaminosis_D
Up to 10,000 ed is no Prob.
Acute overdose requires between 15,000 µg/d (600,000 IU per day) and 42,000 µg/d (1,680,000 IU per day) over a period of several days to months, with a safe intake level being 250 µg/d (10,000 IU per day).[1] Foods contain low levels, and have not been known to cause overdose.
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Oh, that's long gone, actually.
http://en.wikipedia.org/wiki/Hypervitaminosis_D
Up to 10,000 ed is no Prob.
duh,
I knew that ::)
I wasn't awake yet.
(http://www.demotivationalpics.com/albums/uploads/animals/normal_I_Are_Dunecat_by_dankhus.jpg)
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How many i.u.?
I think i am at about 3000.
10,000 usually...
i take no vitamins on saturday though....that day is reserved for drinking...
bench
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Whats the best kind to take? I don't want to take a pill full of Chinese melamine. :-X
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Whats the best kind to take? I don't want to take a pill full of Chinese melamine. :-X
the gel cap kind thats on sale......
bench
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Whats the best kind to take? I don't want to take a pill full of Chinese melamine. :-X
I get mine from the pharmacy.
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I've been getting the Trader Joe's brand gel cap.
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I wonder if this could help someone who has COPD?
I wouldn't think so.
Excellent place for quality vitamins: www.lef.org
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I take 50,000 IU every week.
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Now Foods has a 5000 I.U. softgel. I got mine from iherb.com.
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by David Mendosa
Monday, August 23, 2010
Vitamin D seems to prevent many of our ills. Some studies show that taking large doses of it will treat just about everything from building strong bones to protecting us from strokes and heart failure to reducing our risk of cancer and on to helping us regulate our immune system and control inflammation, our blood pressure, and even our blood glucose. Higher levels of vitamin D is associated with reduced risks for multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.
Reports of the value of vitamin D for preventing even more conditions continue to appear regularly. Low levels of vitamin D are associated with poor lung function among children with asthma, leading them to use more medication to treat it, as the Journal of Allergy and Clinical Immunology recently reported. Vitamin D might treat or prevent allergy to a common mold that can complicate asthma and frequently affects patients with cystic fibrosis, according to a study that the Journal of Clinical Investigation published a few days ago.
As I wrote here last year we nevertheless might have good reason to wonder if all the current hype over vitamin D is nothing more than a resurgence of snake oil claims.
How could just getting out into the sun more or taking just one inexpensive and tiny pill each day work such magic? It seems to be too good to be true. It doesn’t seem to pass the smell test.
Yet we already had a hint to the solution of this major nutritional puzzle when we learned that what we call “vitamin D” isn’t really a vitamin. When scientists discovered vitamin D in the 1920s and 1930s it seemed to work like a vitamin, so that’s what the called it.
“We have confirmed with our recent research that vitamin D isn’t a vitamin at all,” says Professor Trevor Marshall of the school of biological sciences and biotechnology at Murdoch University in Western Australia. It’s a hormone that is made by the body itself.”
And today the other shoe dropped. Several days ago the Wellcome Trust sent me under embargo the advance word on the latest study that journalists could print this evening. The Wellcome Trust is a global charity headquarters in Britain dedicated to improvements in human and animal health.
The main conclusion of this study goes a long way to explaining why vitamin D seems to work its magic throughout our bodies. The journal Genome Research will publish a study led by Sreeram Ramagopalan and Andreas Heger at the University of Oxford.
Using new DNA sequencing technology, they identified more than 200 genes that vitamin D directly influences and created a map of vitamin D receptor binding across the genome. Vitamin D attaches itself to DNA, thus influencing what proteins we make from our genetic code byactivating this receptor.
The researchers discovered 2,776 binding sites for the vitamin D receptor along the length of the genome. These were unusually concentrated near a number of genes associated with susceptibility to autoimmune conditions and to certain cancers. They also found that vitamin D had a significant effect on the activity of 229 genes including PTPN2, associated with Crohn’s disease and type 1 diabetes.
“Vitamin D status is potentially one of the most powerful selective pressures on the genome in relatively recent times,” says Professor George Ebers of the University of Oxford and one of the senior authors of the paper. “Our study appears to support this interpretation and it may be we have not had enough time to make all the adaptations we have needed to cope with our northern circumstances.”
Seldom does basic science like this make the headlines. But this research certainly warrants that. If vitamin D is snake oil, I’ll drink it.
http://www.healthcentral.com/diabetes/c/17/118406/vitamin-isn-snake
Why would you even take Vitamin D unless you live in Scandinavia, since your body makes it with exposure to sunlight? And vitamin D is liposoluble and thus accumulates in bodily tissues and might have delayed toxicity if you used it chronically.
SUCKMYMUSCLE
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Why would you even take Vitamin D unless you live in Scandinavia, since your body makes it with exposure to sunlight? And vitamin D is liposoluble and thus accumulates in bodily tissues and might have delayed toxicity if you used it chronically.
SUCKMYMUSCLE
because its been shown time and time again that those in northern climates are wholely deficient, and people with dark skin in these climates are more likely to suffer from this effect. Not to mention the recent study showing that in evolutionary terms sun damage is required for adequete synthesis, this makes sense with a life span of 30 but not with the longevity seen today. Also, as hunter gatherers we lived outdoors, we have become more and more reliant on artificial light and work indoors for the most part.
also, the research clearly shows it prevents numerious diseases, is safe and is prophylactic. Dont see why one wouldn take it. Toxicity data shows it's very safe.
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because its been shown time and time again that those in northern climates are wholely deficient, and people with dark skin in these climates are more likely to suffer from this effect. Not to mention the recent study showing that in evolutionary terms sun damage is required for adequete synthesis, this makes sense with a life span of 30 but not with the longevity seen today. Also, as hunter gatherers we lived outdoors, we have become more and more reliant on artificial light and work indoors for the most part.
also, the research clearly shows it prevents numerious diseases, is safe and is prophylactic. Dont see why one wouldn take it. Toxicity data shows it's very safe.
Yeah, like I posted, people in Scandinavia probably are adviced to take it. But as for the rest of us, do you have studies showing that sun damaged is required for the body to synthesize it ??? This doesen't make much sense as sun burns is something the body avoids and tries to discourage us from getting. As for benefits from taking it in supplementary form, there are benefits to taking many substances in higher doses than found in the diet, so I don't doubt it although I would like to see data indicating it.
SUCKMYYMUSCLE
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Yeah, like I posted, people in Scandinavia probably are adviced to take it. But as for the rest of us, do you have studies showing that sun damaged is required for the body to synthesize it ??? This doesen't make much sense as sun burns is something the body avoids and tries to discourage us from getting. As for benefits from taking it in supplementary form, there are benefits to taking many substances in higher doses than found in the diet, so I don't doubt it although I would like to see data indicating it.
SUCKMYYMUSCLE
you do know that the majority of people out there that work do so in offices right?...which have no sunlight?.....
bench
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Yeah, like I posted, people in Scandinavia probably are adviced to take it. But as for the rest of us, do you have studies showing that sun damaged is required for the body to synthesize it ??? This doesen't make much sense as sun burns is something the body avoids and tries to discourage us from getting. As for benefits from taking it in supplementary form, there are benefits to taking many substances in higher doses than found in the diet, so I don't doubt it although I would like to see data indicating it.
SUCKMYYMUSCLE
im talking sun damage over time, accumulation, not burns to an extent. Makes perfect sense evolutionarily.
I do have data, quite a bit, ill post it tom when im at work. Health canada recently recommended all citizens take 1000 ius per day to prevent cancer. Anyway, ill post it up, its all on pubmed if anyone wants to look.
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im talking sun damage over time, accumulation, not burns to an extent. Makes perfect sense evolutionarily.
I do have data, quite a bit, ill post it tom when im at work. Health canada recently recommended all citizens take 1000 ius per day to prevent cancer. Anyway, ill post it up, its all on pubmed if anyone wants to look.
off topic, but since you are actively posting in this thread.....how much NAC should a person take on average?
bench
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im talking sun damage over time, accumulation, not burns to an extent. Makes perfect sense evolutionarily.
You did use the expression "sun burns" so don't blame me for interpreting it that way. It makes sense evolutionarily? Most hunter gatherers outside the tropics are not exposed to sunlight anyway that would result in damage to the epidermis(is this what you are implying), and in most of the rest of the year they don't get enough sun exposure to develop tans anyway even if they stay out all day long. It wouldn't make sense that vitamin D could only be synthesized by enough sun exposure that would require burns. In fact, Nothern Europeans developed white skin so as to maximize vitamin D production since white skin absorbs maximum sun rays. And getting sun burns is something that we are discouraged both physiologically as well as psychologically. Most people avoid midday sun and get cover. If getting sun burs is required for vitamin D production, then why are we discouraged from staying out in the sun by our own bodies? We get nausea, headaches and painful skin burns if we stay out in the Sun for long. How does this make sense evolutionarilly?
I do have data, quite a bit, ill post it tom when im at work. Health canada recently recommended all citizens take 1000 ius per day to prevent cancer. Anyway, ill post it up, its all on pubmed if anyone wants to look.
Have you checked Canada's latitude? Of course you probably do need vitamin D in Canada. I don't think people in the tropics or subtropical regions require vitamin D supplementation at all. I live in a subtropical region and I have never developed a vitamin D deficiency even though I don't get sunlight nor drink milk and I don't know anyone either lolll.
SUCKMYMUSCLE
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I can testify to the power of Vitamin D. I have been on nights for the past 3 years 7pm - 7am. Over a year ago I just couldn't take it anymore. I was feeling like shit. My sleep cycle was all fucked up. Insomnia, irritable etc. Just felt like shit. I also noticed my lower calves would cramp ALL THE TIME. Well I went to the doctor to get a physical and some bloodwork. I told her I wanted my Vitamin D levels checked and the girl doctor looked at me like I just asked her for blowjob. My D levels came back not only low but CRITICALLY low. I started megadosing Vitamin D about 7-10K IUs per day and getting a lot more sun. Months later I started feeling A LOT BETTER! Im still on nights but my sleep pattern and energy levels are better and I no longer have the cramping. I never knew lack of certain vitamins can cause muscle cramping. I always knew electrolytes caused cramping etc. My doctor is a fucking idiot. when my D levels came back critically low she didn't even speak to them let alone offer me prescription strength Vitamin D pills. I swear doctors don't give a shit about stuff that can't be cured at the behest of prescription drugs.
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you do know that the majority of people out there that work do so in offices right?...which have no sunlight?.....
bench
what are you using it for. anti-oxidant probably 500-1000mgs, as a mucolytic probably more.
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You did use the expression "sun burns" so don't blame me for interpreting it that way. It makes sense evolutionarily? Most hunter gatherers outside the tropics are not exposed to sunlight anyway that would result in damage to the epidermis(is this what you are implying), and in most of the rest of the year they don't get enough sun exposure to develop tans anyway even if they stay out all day long. It wouldn't make sense that vitamin D could only be synthesized by enough sun exposure that would require burns. In fact, Nothern Europeans developed white skin so as to maximize vitamin D production since white skin absorbs maximum sun rays. And getting sun burns is something that we are discouraged both physiologically as well as psychologically. Most people avoid midday sun and get cover. If getting sun burs is required for vitamin D production, then why are we discouraged from staying out in the sun by our own bodies? We get nausea, headaches and painful skin burns if we stay out in the Sun for long. How does this make sense evolutionarilly?
Have you checked Canada's latitude? Of course you probably do need vitamin D in Canada. I don't think people in the tropics or subtropical regions require vitamin D supplementation at all. I live in a subtropical region and I have never developed a vitamin D deficiency even though I don't get sunlight nor drink milk and I don't know anyone either lolll.
SUCKMYMUSCLE
You did use the expression "sun burns" so don't blame me for interpreting it that way. It makes sense evolutionarily? Most hunter gatherers outside the tropics are not exposed to sunlight anyway that would result in damage to the epidermis(is this what you are implying), and in most of the rest of the year they don't get enough sun exposure to develop tans anyway even if they stay out all day long. It wouldn't make sense that vitamin D could only be synthesized by enough sun exposure that would require burns
Your first sentence is pure conjecture, hunter gatherers were outside a 1000% more the we are now, the vast majority of all activities are done inside now.
. In fact, Nothern Europeans developed white skin so as to maximize vitamin D production since white skin absorbs maximum sun rays. And getting sun burns is something that we are discouraged both physiologically as well as psychologically. Most people avoid midday sun and get cover. If getting sun burs is required for vitamin D production, then why are we discouraged from staying out in the sun by our own bodies? We get nausea, headaches and painful skin burns if we stay out in the Sun for long. How does this make sense evolutionarilly?
i already corrected or clarified myself, sun damage.accumulation over time. It makes perfect sense, the body is a shitty machine, why do we lack the enzyme to synthesize vitamin c? doesnt seem efficient, evolution is not directed.
So previously we spent almost all our time outdoors, in fact the vast majority. This would dictate that the vitamin d conversion would be slow, otherwise it would get toxic fast. Thus, now we get a couple hours max and the process is still the same slow process. Add in the longevity we now live with and things like cancer become a factor, where as cancer is not a big of a concern if you die at 30. Anyway, there is data to back this up, a pretty new study in fact. Ill post it tom.
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You did use the expression "sun burns" so don't blame me for interpreting it that way. It makes sense evolutionarily? Most hunter gatherers outside the tropics are not exposed to sunlight anyway that would result in damage to the epidermis(is this what you are implying), and in most of the rest of the year they don't get enough sun exposure to develop tans anyway even if they stay out all day long. It wouldn't make sense that vitamin D could only be synthesized by enough sun exposure that would require burns
Your first sentence is pure conjecture, hunter gatherers were outside a 1000% more the we are now, the vast majority of all activities are done inside now.
. In fact, Nothern Europeans developed white skin so as to maximize vitamin D production since white skin absorbs maximum sun rays. And getting sun burns is something that we are discouraged both physiologically as well as psychologically. Most people avoid midday sun and get cover. If getting sun burs is required for vitamin D production, then why are we discouraged from staying out in the sun by our own bodies? We get nausea, headaches and painful skin burns if we stay out in the Sun for long. How does this make sense evolutionarilly?
i already corrected or clarified myself, sun damage.accumulation over time. It makes perfect sense, the body is a shitty machine, why do we lack the enzyme to synthesize vitamin c? doesnt seem efficient, evolution is not directed.
So previously we spent almost all our time outdoors, in fact the vast majority. This would dictate that the vitamin d conversion would be slow, otherwise it would get toxic fast. Thus, now we get a couple hours max and the process is still the same slow process. Add in the longevity we now live with and things like cancer become a factor, where as cancer is not a big of a concern if you die at 30. Anyway, there is data to back this up, a pretty new study in fact. Ill post it tom.
Necrosis, you claimed that sun damage accumulation over time is required for vitamin D synthesis. From a purely logical standpoint, this doesen't make sense since most people outside the tropical and sutropical areas of the World don't get any Sun damage at all even during the Summer, let alone during the rest of the year.
Since vitamin D is essential for life and since there isn't enough Sun outside tropical and subtropical regions of the World to cause Sun burns, and since Humans have lived outside tropical and subtropical regions of the World since pre-historic times, then ergo, a simple logical deduction indicates that an amount of Sun exposure that results in burns is not needed for the body to synthesize vitamin D.
As for vitamin C, it is fairly abundant throughout most food sources, hence there was never a need for us to developed physiological characteristics that would allow us to synthesize vitamin C. We evolved from fruitarian apes and vitamin C is very abundant in most fruits. As for Humans who migrated to areas where fruits are not abundant, they could still get enough vitamin C from the diet to survive. Remember that what is optimum and what is required are two different things. We may not get enough vitamin C from the diet to have all the benefits we could have from it - and I take several grams of it a day because of this -, but we do get enough to survive. Natural selection is about survival and not optimum health.
SUCKMYMUSCLE
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I can testify to the power of Vitamin D. I have been on nights for the past 3 years 7pm - 7am. Over a year ago I just couldn't take it anymore. I was feeling like shit. My sleep cycle was all fucked up. Insomnia, irritable etc. Just felt like shit. I also noticed my lower calves would cramp ALL THE TIME. Well I went to the doctor to get a physical and some bloodwork. I told her I wanted my Vitamin D levels checked and the #girl doctor looked at me like I just asked her for blowjob. My D levels came back not only low but CRITICALLY low. I started megadosing Vitamin D about 7-10K IUs per day and getting a lot more sun. Months later I started feeling A LOT BETTER! Im still on nights but my sleep pattern and energy levels are better and I no longer have the cramping. I never knew lack of certain vitamins can cause muscle cramping. I always knew electrolytes caused cramping etc. My doctor is a fucking idiot. when my D levels came back critically low she didn't even speak to them let alone offer me prescription strength Vitamin D pills. I swear doctors don't give a shit about stuff that can't be cured at the behest of prescription drugs.
God damn thats alot of vitamin D. I was taking 2000 IU per day and didnt really notice shit so maybe thats why. Gonna give 7000IU a try. I;m sure half these generic vitamins are garbage anyways hence the need for megadosing.
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God damn thats alot of vitamin D. I was taking 2000 IU per day and didnt really notice shit so maybe thats why. Gonna give 7000IU a try. I;m sure half these generic vitamins are garbage anyways hence the need for megadosing.
Well bro it takes time first off to notice changes. It took a good 9 months to start to feel the difference. It was subtle but very noticeable over time. And yes there is a lot of crappy vitamins and minerals out there just like roids.
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I can testify to the power of Vitamin D. I have been on nights for the past 3 years 7pm - 7am. Over a year ago I just couldn't take it anymore. I was feeling like shit. My sleep cycle was all fucked up. Insomnia, irritable etc. Just felt like shit. I also noticed my lower calves would cramp ALL THE TIME. Well I went to the doctor to get a physical and some bloodwork. I told her I wanted my Vitamin D levels checked and the #girl doctor looked at me like I just asked her for blowjob. My D levels came back not only low but CRITICALLY low. I started megadosing Vitamin D about 7-10K IUs per day and getting a lot more sun. Months later I started feeling A LOT BETTER! Im still on nights but my sleep pattern and energy levels are better and I no longer have the cramping. I never knew lack of certain vitamins can cause muscle cramping. I always knew electrolytes caused cramping etc. My doctor is a fucking idiot. when my D levels came back critically low she didn't even speak to them let alone offer me prescription strength Vitamin D pills. I swear doctors don't give a shit about stuff that can't be cured at the behest of prescription drugs.
How much was considered "CRITICALLY low"? My doctor told me that my vit d is low but how low is critical?
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How much was considered "CRITICALLY low"? My doctor told me that my vit d is low but how low is critical?
Well mine was 25 I believe. I think up near 100 is considered normal. 100 or 120 I can't remember. It actually said critically low on my lab results.
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interesting recent study on vitamin D and testosterone in men.
http://www.ncbi.nlm.nih.gov/pubmed/21154195