ISUCKMUSCLEDICK
I
hoped thought you'd choked on a cake!!
Your comprehension skills are terrible.
As I told you, quit your filibustering attempt to conflate an implied absolute relevancy of rat studies with the, de facto, lack thereof.
Nobody said rat studies per-se are absolutely irrelevant (drugs are tested on rats, nah really?) What was said, was that your rat studies thus far presented are not herein relevent to this example; this by virtue that you have absolutely failed to present a single human study corroborating them, thus you - de facto - vindicate our position.
Or perhaps (and warm up your overly raped asshole once more) you'd like to point to the many drugs that reach phase 5 of drug trials based on the murine pre-clincal phase alone then? LOL ROARING WITH FUCKIN LAUIGHTER, you know-nothing, fucking wet ponce! Did you miss my previous post wherein I declared my previous years working with Merck? But do carry on, wankers like you are the proverbial fish in the barrel LOL
Also, we are discussing Aspartame, so if you could stay on point whilst saving your digressive double talk regarding oro-sensory stimulation, artificial sweeteners and the Cephalic phase of secretion thereof; you are only serving to dig a deeper hole for your fat, virginal self!
Sweet solutions, which are assumed to be highly palatable, have been tested for their efficacy in eliciting cephalic phase insulin release in humans. As discussed above, both nutritive and non-nutritive sweet solutions elicit cephalic phase insulin release in rats. However, in humans, sweet solutions do not appear to be particularly effective stimuli for eliciting the response; in several studies, cephalic phase insulin release was not observed after subjects tasted solutions sweetened with aspartame, sucrose (nutritive) or saccharin (non-nutritive). Although two studies did demonstrate significant increases in pre-absorptive insulin release following either ingesting sweetened solution or tasting a glucose solution, the response to this type of stimulus appears to be less robust than to a whole food.
To determine whether sweet-tasting solutions are effective elicitors of cephalic phase insulin release (CPIR) in humans, two studies were conducted using nutritive and nonnutritive sweeteners as stimuli. Normal weight men sipped and spit four different solutions: water, aspartame, saccharin, and sucrose.
... no significant increases in plasma insulin were observed after subjects tasted the sweetened solutions.
These results suggest that nutritive and nonnutritive sweeteners in solution are not adequate stimuli for the elicitation of CPIR.
For the time being, the money centers on the psychological components of the human equation, but you wont know that, because you are a mongol cu
nt!
http://www.sciencedirect.com/science/article/pii/S0924224496100479http://www.sciencedirect.com/science/article/pii/003193849400373DTO REPEAT: YOU HAVE NO EVIDENCE THAT ASPARTAME ALONE IS INSULINOTROPIC IN HUMANS, NONE!If you want to present studies employing various food loads and their insulintropic resonance thereafter, then perhaps, dickhead, why not tell folks to stay away from the "allosteric hazard" that is Leucine and Glucose combos. Also, moron, you do realise that glucagon-like peptide 1 is a fucking satiety hormone? More so, you do realise the relevance thereof both these points taken in tandem re: any argument yourself and
Mongol Methyl Mike may have been struggling (like cretins) to cobble together? not that that pair of you are spastics you understand!
Now, idiot, human studies with Aspartame, or, and as said, fuck off.Little boy, you are a wanker pontificating within the walls of a shit forum, take a day off, sonny!
Are you this much of a failure in real life? I bet you're sat there - stained curtains, shit strewn floor - wanking off about my fine tits as you type? squalid little herbert!
Owned by a lowly girl... on a bodybuilding forum no less!!
hahahahahahaha, you are a quirky little boy.
