You don`t use a comma when you separate with and, hope this helps.
It's called a serial comma or the Oxford comma. Commas are used to separate the elements in a series (three or more things). There are situations in which, if you don't use this comma (especially when the list is complex or lengthy), these last two items in the list will try to glom together. Using a comma between
all the items in a series, including the last two, avoids this problem.
Your welcome.