REVIEW: “DEPLETION AND SUPPLEMENTATION OF COQ10 IN SECONDARY DEFIFIENCY DISORDERS”. MANTLE ET AL. FRONT. BIOSCI. (LANDMARK ED.) 2022; 27(12):322.
CoQ10 - ATP synthesis through mitochondrial oxidative phosphorylation.
- Endogenously synthesized lipid soluble antioxidant (AO) protection cellular/subcellular organelle membranes from free radical induced oxidative stress.
- Metabolism of lysosomes, sulphides, amino acids (AA), and cholesterol.
- Anti-inflammatory agent.
The review focus on secondary CoQ10 deficiencies.
The most well-known CoQ10 deficiency disorder is heart failure (HF). HF can be considered a condition of myocardial energy starvation, characterized by mitochondrialenergy dysfunction, reduced ATP production, increased free radical generation/oxidative stress, and inflammation. Depletion of both circulatory and cardiac tissue levels of CoQ10 have been reported. Normal plasma CoQ10: 0.8-1.2 mikrogram/ml. Molyneux reported an independent association between reduced P-CoQ10 and increased risk of mortality in patients with chronic HF. The association with increased mortality was stronger for CoQ10 than NT-proBNP!!!
CoQ10 also lower in cardiac tissue in HF.
- NYHA I 0.4 mikrogram/mg
- NYHA II 0.34 - “” -
- NYHA III, IV 0.28 - “” -
SYMBIO STUDY: Suppl. W. CoQ10 sign. Reduced RR of cardiac death (43%) and all-cause mortality (42%)! MACE study showed even better results.
Chronic Kidney Disease (CKD).
CoQ10 lower in CKD. One study (3x100 mg CoQ10 for 3 months) improved kidney function (creatinine).
Non-alcohol Fatty Liver Disease (NAFLD).
NAFLD have lower CoQ10 levels and associated inflammation and cirrhosis development. One study (100 mg for 1-3 months) improved liver values and lowered CRP.
Type II DM patients supplemented with CoQ10 lowered HBA1c.
Early stage Parkinson’s had some benefit of CoQ10. High-dose CoQ10 reduced biomarkers of oxidative stress (malondialdehyd, total AO capacity), reduced IL-6, TNF alpha and improved fatigue in MS patients. Patients with fibromyalgia benefitted from CoQ10. CoQ10+carnitine+omega 3 FA over 12 months improved visual function in patients with age related macular degeneration!
There is evidence for mitochondrial dysfunction, oxidative stress and inflammation in the pathogenesis of COPD. Blood levels of CoQ10 are decreased in COPD patients. 2 randomized controlled trials. One study 50 mg/day for 8 weeks and the other one 180 mg/day for 8 weeks. Both studies showed sign improvement in spirometry function. Weak studies show that CoQ10 might have effect on upper rest. Viral infections like C-19, flu, swine flu etc…Asthma has increased oxidative stress and inflammation of the airway. Blood levels of CoQ10 are reduced in asthma patients. Supplementation of CoQ10 (100 mg/day for 4 weeks) improved airflow in asthmatic patients!
Most cancers have lower blood levels of CoQ10. Folkers showed improved survival in patients with end stage cancers following suppl. w. CoQ10 (300 mg/day for up to 9 years)!
200-600 mg/day improved sperm and ovarian function.
CoQ10 have some good effects on hyperthyroidism, ulcerative colitis, RA, periodontal disease.
The best evidence for CoQ10 is on HF w. 30 randomized trials and confirmation by meta analysis.
Reference interval S/P CoQ10 0.5-1.7 mikroM.
Conflict of interest: Mantle is a medical advisor to Pharma Nord.
