Wow. How much of a pussy do you intend on being? So weak you can't even handle weed. Get the fuck outta here.
Marijuana withdrawals. My fucking God. You probably shouldn't do anything but knit and wash dishes you fuckin twat.
LOL.
its real, on vakay so will litter the board with info only 1% of the board cares to read. It's not sad to have withdrawal it's sad that you get there.
MJ withdrawal is real, I agree he is a pussy. It only happens in cases of frank abuse, we do have an endocannabionoid system (anandamide is the ligand, like endorphins to the opiate system), the withdrawal is like a weak opiate and alcohol withdrawal.
lit
Drug Alcohol Depend. 2014 Oct 1;143:189-97. doi: 10.1016/j.drugalcdep.2014.07.027. Epub 2014 Aug 1.
Abstinence phenomena of chronic cannabis-addicts prospectively monitored during controlled inpatient detoxification: cannabis withdrawal syndrome and its correlation with delta-9-tetrahydrocannabinol and -metabolites in serum.
Bonnet U1, Specka M2, Stratmann U3, Ochwadt R4, Scherbaum N2.
Author information
Abstract
OBJECTIVE:
To investigate the course of cannabis withdrawal syndrome (CWS) within a controlled inpatient detoxification setting and to correlate severity of CWS with the serum-levels of delta-9-tetrahydrocannabinol (THC) and its main metabolites 11-hydroxy-delta-9-tetrahydrocannabinol (THC-OH) and 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH).
METHODS:
Thirty-nine treatment-seeking chronic cannabis dependents (ICD-10) were studied on admission and on abstinent days 2, 4, 8 and 16, using a CWS-checklist (MWC) and the Clinical Global Impression-Severity scale (CGI-S). Simultaneously obtained serum was analysed to its concentration of THC, THC-OH and THC-COOH.
RESULTS:
MWC peaked on day 4 (10.4 ± 4.6 from 39 points) and declined to 2.9 ± 2.4 points on day 16. Women had a significantly stronger CWS than men. The CWS was dominated by craving>restlessness>nervousness>sleeplessness. CGI-S peaked with 5 out of 7 points. On admission, THC and its metabolites did negatively correlate with the severity of CWS. There was no significant correlation afterwards, no matter if CWS was medicated or not. THC-OH in serum declined most rapidly below detection limit, on median at day 4. At abstinence day 16, the THC-levels of 28.2% of the patients were still above 1g/ml (range: 1.3 to 6.4 ng/ml).
CONCLUSIONS:
CWS increased and then decreased without any correlation between its severity and the serum-levels of THC or its main metabolites after admission. According to the CGI-S, most patients achieved the condition of 'markedly ill'. Serum THC-OH was most clearly associated with recent cannabis use. Residual THC was found in the serum of almost one-third of the patients at abstinence day 16.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Clin Pharmacol Ther. 2015 Jun;97(6):571-4. doi: 10.1002/cpt.109. Epub 2015 Apr 17.
Cannabinoid replacement therapy (CRT): Nabiximols (Sativex) as a novel treatment for cannabis withdrawal.
Allsop DJ1,2, Lintzeris N2,3, Copeland J4, Dunlop A5,6, McGregor IS1.
Author information
Abstract
Cannabis is a common recreational drug that is generally considered to have low addictive potential. However, an increasing number of cannabis users are seeking treatment for dependence on the drug. There is interest in using agonist (substitution) pharmacotherapies to treat cannabis dependence and here we outline a novel approach involving a buccal spray (nabiximols) that contains tetrahydrocannabinol (THC) and cannabidiol (CBD). We review recent research with nabiximols and highlight findings relevant to clinical practice.
© 2015 American Society for Clinical Pharmacology and Therapeutics.