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Getbig Main Boards => Gossip & Opinions => Topic started by: DK II on August 10, 2007, 06:39:08 AM
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Looks like the skeleton is playing a bigger role in energy metabolism than thought.
http://www.cell.com/content/article/abstract?uid=PIIS0092867407007015
Endocrine Regulation of Energy Metabolism by the Skeleton
The regulation of bone remodeling by an adipocyte-derived hormone implies that bone may exert a feedback control of energy homeostasis.
To test this hypothesis we looked for genes expressed in osteoblasts, encoding signaling molecules and affecting energy metabolism. We show here that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in β-cell proliferation, insulin secretion, and insulin sensitivity. In contrast, mice lacking the osteoblast-secreted molecule osteocalcin display decreased β-cell proliferation, glucose intolerance, and insulin resistance. Removing one Osteocalcin allele from OST-PTP-deficient mice corrects their metabolic phenotype. Ex vivo, osteocalcin can stimulate CyclinD1 and Insulin expression in β-cells and Adiponectin, an insulin-sensitizing adipokine, in adipocytes; in vivo osteocalcin can improve glucose tolerance. By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism.
Edit: I marked the important sentences for dumbfucks like EL Mariachi who surrender at the sight of words like 'Endocrine'. ;D
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Full text here
http://www.cell.com/content/article/fulltext?uid=PIIS0092867407007015
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ohh thats great donkeykong, i have a burning sensation reading this, you moron.
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ohh thats great donkeykong, i have a burning sensation reading this, you moron.
nobody forces you to, idiot.
reading isn't a crime, you know that?
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good article...
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nobody forces you to, idiot.
reading isn't a crime, you know that?
i didnt even read it, im too just messin with ya, my good japanese friend.
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good article...
hahaha, dont pretend like you understood it
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hahaha, dont pretend like you understood it
umm.... not pretending.... i actually did ::)
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If you can concentrate hard enough to understand this article, then you are not working out hard enough.
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If you can concentrate hard enough to understand this article, then you are not working out hard enough.
i printed it and read it while doing cardio.... :)
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i jerk off to completion while jogging.
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i didnt even read it, im too just messin with ya, my good japanese friend.
Yeah i know you're almost illiterate... ;) ;D ;D ;D