Getbig Bodybuilding, Figure and Fitness Forums
Getbig Main Boards => Gossip & Opinions => Topic started by: shiftedShapes on August 15, 2007, 03:13:50 AM
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why can't GH15 gets his hands on this stuff? GH15 come on we want to see you bulk up like Wendy the Whippet.
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kiwiol says that Mysotatin Inhibition is a myth. It can only work in the embryonic stage.
GH15, help us out here. Is there such a thing as Myostatin Inhibitors?
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my god people...a good creatine and carb based post work out shake is not good enough anymore
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NO
Only by 1 in a Billion by natural selection in one man in England and another by a German boy five or six years ago
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NO
Only by 1 in a Billion by natural selection in one man in England and another by a German boy five or six years ago
Flex Wheeler has it, and Victor Richards had an extra X chromesome.
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I dont know why there isnt more interest in this in the bodybuilding world. Its such a temporary culture.
Live for the moment. If you work this hard to make muscle why is there no interest in keeping it?
Do you guys really want to loose all your gains, because you will. Name one retired pro that still looks like he was ever a bodybuilder.
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I dont know why there is no more interest in this in the bodybuilding world. Its such a temporary culture.
Live for the moment. If you work this hard to make muscle why is there no interest in keeping it?
Do you guys really want to loose all your gains, because you will. Name one retired pro that still looks like he was ever a bodybuilder.
Anthony Michael Hall.
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I dont get it, fill me in.
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I dont get it, fill me in.
Well imo, he never lost those real good gains, that he gained in the 1980's.
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Well imo, he never lost those real good gains, that he gained in the 1980's.
is he 8% bro?
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Well imo, he never lost those real good gains, that he gained in the 1980's.
Bud Fox
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why can't GH15 gets his hands on this stuff? GH15 come on we want to see you bulk up like Wendy the Whippet.
if he does that he won't live to be 186 like you will looking almost the same as you do now with only a few wrinkles.
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is he 8% bro?
Hes got the deep Gaspariesque striations coming through on his glutes, id say hes around 6%, dudes ripped.
Hes still rocking it amadeus style aswell.
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if he does that he won't live to be 186 like you will looking almost the same as you do now with only a few wrinkles.
Yeah but if he doesn't turn himself into a freak what's going to keep me amused for all these years?
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Yeah but if he doesn't turn himself into a freak what's going to keep me amused for all these years?
hahahaha, i hear you man, but try to take it easy on him big man, we can't all be as huge, ripped, and flexible as you. ;D
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hahahaha, i hear you man, but try to take it easy on him big man, we can't all be as huge, ripped, and flexible as you. ;D
That much is clear from your pics.
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I'm serious here, when are BBers going to get their hands on some of this stuff and show us the possibilities.
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I'm serious here, when are BBers going to get their hands on some of this stuff and show us the possibilities.
I agree, I think it is already being used to be honest with you. I dont see how Jay and Ronnie can stay that big that long all year round with hardly a change or health problem, it just isnt possible. Even with the normal gear there are dips and platueaus, these guys are just too consistently the same.
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I'm serious here, when are BBers going to get their hands on some of this stuff and show us the possibilities.
Got any links to articles, studies, etc?
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I dont know why there isnt more interest in this in the bodybuilding world. Its such a temporary culture.
Live for the moment. If you work this hard to make muscle why is there no interest in keeping it?
Do you guys really want to loose all your gains, because you will. Name one retired pro that still looks like he was ever a bodybuilder.
Tom Prince. 100% Natural......... oh and Advil ;D
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Ok, I'll find it myself.
Here's a link to one article:
http://www.fool.com/investing/general/2004/07/02/muscle-in-wyeths-pipeline.aspx (http://www.fool.com/investing/general/2004/07/02/muscle-in-wyeths-pipeline.aspx)
"Last month, the drug manufacturer began a phase 1 trial of myo-29, a monoclonal antibody that blocks the production of myostatin, a natural occurring protein in the body. A Wyeth-sponsored study recently published in the New England Journal of Medicine suggests why blocking myostatin may be desirable. At the center of that investigation was a 4-year-old boy with twice the muscle mass and half the body fat of other children his age. The boy has an apparently unique genetic mutation that inhibits myostatin production. From this and earlier research, Wyeth has determined that the protein inhibits muscle growth."
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kiwiol says that Mysotatin Inhibition is a myth. It can only work in the embryonic stage.
GH15, help us out here. Is there such a thing as Myostatin Inhibitors?
yeah you have to be bred
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That much is clear from your pics.
hahahahhaa, post a picture of that massive 13 inch armed side triceps again, let everybody see the BEAST!!!!!!!!!!!!!!!
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hahahahhaa, post a picture of that massive 13 inch armed side triceps again, let everybody see the BEAST!!!!!!!!!!!!!!!
Master Blaster found the article all by himself why don't you follow his good example and track down my pic, and then post it up with a "BOOOOOOOOOM"
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didn't i see some pics of a greman baby that had a genetic defect that led to myostatin inhibition? anyone know what i am referring to?
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Sorry dudes... wrong again.
There is another drug that's being tested here in Ireland that blocks the actions of myostatin and shows pretty drastic effects even in adult animals (it's been tested on chickens and rats producing 30% increases in skeletal muscle mass in as little as six weeks), cessation of the drug undoes the muscle increase.
The Luke
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Sorry dudes... wrong again.
There is another drug that's being tested here in Ireland that blocks the actions of myostatin and shows pretty drastic effects even in adult animals (it's been tested on chickens and rats producing 30% increases in skeletal muscle mass in as little as six weeks), cessation of the drug undoes the muscle increase.
The Luke
Links, names, etc.
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I heard bodybuilders are starting to implement gamma rays into their supplement regiments. You build so much muscle your friends will be green with envy.
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Google it dude...
If I remember correctly there are several drugs that interfere with myostatin production... I think (not sure) that one of them is called SRS-71 or something like that.
Each and every major pharmaceutical company is researching this at the moment: just google the words "myostatin"; "inhibitor" and "studies" and avoid the bodybuilding sites.
The Luke
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kiwiol says that Mysotatin Inhibition is a myth. It can only work in the embryonic stage.
It`s not a myth, myostatin is a negative regulator of skeletal muscle growth. Gene knockouts in embryonic mice result in hypermuscular adult mice. Recent work in which gene expression 'knockouts' were effected in adult mice showed that "Tamoxifen administration to 4-mo-old Mstn[f/f]/Cre+ mice reduced myostatin mRNA expression to less than 1% of normal, which increased muscle mass ~25% over the following 3 mo in both male and female mice". It was concluded that "even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass".
As far as bodybuilding goes, it'll be sometime before it`s possible to start messing with a person`s genes directly in a clandestine lab, at least without significant and irreversible effects. The easiest way will be to use antibodies or better anti-sense RNA; this will become a reality over the next decade or so. Basically the DNA (usually double-stranded, of course) that defines this particular gene produces an mRNA (messenger RNA which is single-stranded). This mRNA is then used as a template for protein synthesis. Antisense RNA is, essentially, the introduction of anti-sense (or complimentary sequence) RNA that binds to the mRNA. When it is double-stranded, the mRNA cant be used in protein synthesis and so protein expression (in this case myostatin expression) is inhibited.
The problem is, there are numerous genes involved in muscular hypertrophy, and also muscular dystrophy. The function of myostatin itself is not fully understood either, so those at the forefront will have to weigh up the significant risks with the rewards.
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Google it dude...
Gee, thanks.
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"Tamoxifen administration to 4-mo-old Mstn[f/f]/Cre+ mice reduced myostatin mRNA expression to less than 1% of normal, which increased muscle mass ~25% over the following 3 mo in both male and female mice"
Is this right?
Tamoxifen citrate is the generic name for the anti-estrogen nolvadex.
The Luke
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Is this right?
Tamoxifen citrate is the generic name for the anti-estrogen nolvadex.
The Luke
Yes, this but was only to stimulate expression of the transgene which is under the control of a tamoxifen-inducible promoter (which drives gene expression).
http://ajpendo.physiology.org/cgi/content/abstract/00531.2006v1 - abstract only here, I can get a copy of the full paper if needed.