Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Bodybuilding Boards => Steroids Info & Hardcore => Topic started by: theworm on September 13, 2008, 07:02:57 AM
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finally the myth can be dispelled:
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.Borst SE, Conover CF, Carter CS, Gregory CM, Marzetti E, Leeuwenburgh C, Vandenborne K, Wronski TJ.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Gainesville, Florida 32608-1197, USA. seborst@ufl.edu
At replacement doses, testosterone produces only modest increases in muscle strength and bone mineral density in older hypogonadal men. Although higher doses of testosterone are more anabolic, there is concern over increased adverse effects, notably prostate enlargement. We tested a novel strategy for obtaining robust anabolic effects without prostate enlargement. Orchiectomized (ORX) male rats were treated for 56 days with 1.0 mg testosterone/day, with and without 0.75 mg/day of the 5alpha-reductase inhibitor MK-434. Testosterone administration elevated the prostate dihydrotestosterone concentration and caused prostate enlargement. Both effects were inhibited by MK-434. ORX produced a catabolic state manifested in reduced food intake, blunted weight gain, reduced hemoglobin concentration, decreased kidney mass, and increased bone resorption, and in the proximal tibia there was both decreased cancellous bone volume and a decreased number of trabeculae. In soleus and extensor digitorum longus muscles, ORX reduced both the percentage of type I muscle fibers and the cross-sectional area of type 1 and 2 fibers. Testosterone administration caused a number of anabolic effects, including increases in food intake, hemoglobin concentration, and grip strength, and reversed the catabolic effects of ORX on bone. Testosterone administration also partially reversed ORX-induced changes in muscle fibers. In contrast to the prostate effects of testosterone, the effects on muscle, bone, and hemoglobin concentration were not blocked by MK-434 (a 5aplha reducatase inhibitor). Our study demonstrates that the effects of testosterone on muscle and bone can be separated from the prostate effects and provides a testable strategy for combating sarcopenia and osteopenia in older hypogonadal men.
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finally the myth can be dispelled:
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.Borst SE, Conover CF, Carter CS, Gregory CM, Marzetti E, Leeuwenburgh C, Vandenborne K, Wronski TJ.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Gainesville, Florida 32608-1197, USA. seborst@ufl.edu
At replacement doses, testosterone produces only modest increases in muscle strength and bone mineral density in older hypogonadal men. Although higher doses of testosterone are more anabolic, there is concern over increased adverse effects, notably prostate enlargement. We tested a novel strategy for obtaining robust anabolic effects without prostate enlargement. Orchiectomized (ORX) male rats were treated for 56 days with 1.0 mg testosterone/day, with and without 0.75 mg/day of the 5alpha-reductase inhibitor MK-434. Testosterone administration elevated the prostate dihydrotestosterone concentration and caused prostate enlargement. Both effects were inhibited by MK-434. ORX produced a catabolic state manifested in reduced food intake, blunted weight gain, reduced hemoglobin concentration, decreased kidney mass, and increased bone resorption, and in the proximal tibia there was both decreased cancellous bone volume and a decreased number of trabeculae. In soleus and extensor digitorum longus muscles, ORX reduced both the percentage of type I muscle fibers and the cross-sectional area of type 1 and 2 fibers. Testosterone administration caused a number of anabolic effects, including increases in food intake, hemoglobin concentration, and grip strength, and reversed the catabolic effects of ORX on bone. Testosterone administration also partially reversed ORX-induced changes in muscle fibers. In contrast to the prostate effects of testosterone, the effects on muscle, bone, and hemoglobin concentration were not blocked by MK-434 (a 5aplha reducatase inhibitor). Our study demonstrates that the effects of testosterone on muscle and bone can be separated from the prostate effects and provides a testable strategy for combating sarcopenia and osteopenia in older hypogonadal men.
I have read this same thing about 5aplha reducatase inhibitors not affecting muscle gains or to a very small amount. I tried Dutriside(sp) or Avodart for a about 6 weeks for my prostate BPH and i can say it worked well, reducing/eliminating my BPH symptoms. I did not notice and loss in muscle or strength. I will say though it did seem to throw me off a bit hormonaly, not sure exactlly how but after stopping it I just felt a bit off for a while :-\
Im thinking such a big adjustment in DHT levels has to have some effect, both positive and of course as with almost anything some negative. Finistride is supposedly milder or less effective than Dutriside at its intended use so maybe the effect will be less with it?
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It will diminish strength however, .... which can hinder muscle growth.
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i noticed years ago when i was natural and started taking it my muscles would hit their failure point 1-2 reps sooner than they did before
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i noticed years ago when i was natural and started taking it my muscles would hit their failure point 1-2 reps sooner than they did before
this may be psychological as well,,,like the beginner taking his first shot of test then "lifting 30 more pounds that same day."
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It will diminish strength however, .... which can hinder muscle growth.
based on what evidence,,,the only real evidence out there says it does NOT interfer with strength.
read the study:
http://www.ncbi.nlm.nih.gov/pubmed/17488806?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum