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Getbig Main Boards => Gossip & Opinions => Topic started by: theworm on May 30, 2010, 05:25:17 PM

Title: topical spironolactone?
Post by: theworm on May 30, 2010, 05:25:17 PM
anyone use this for hair loss?

i read it decreased DHT in the scalp.   I tried rogaine, but it didn't do anything, and i am not ready to get on finasteride yet due to all the side effects.

opinions?
Title: Re: topical spironolactone?
Post by: 240 is Back on May 30, 2010, 05:28:59 PM
Thin to win baby.

When you get the answer, share it with all of us please
Title: Re: topical spironolactone?
Post by: chaos on May 30, 2010, 05:31:02 PM
anyone use this for hair loss?

i read it decreased DHT in the scalp.   I tried rogaine, but it didn't do anything, and i am not ready to get on finasteride yet due to all the side effects.

opinions?
Bald is beautiful, quit being a bitch about it.
Title: Re: topical spironolactone?
Post by: theworm on May 30, 2010, 05:49:30 PM
Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris.

Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G.

Department of Dermatology, University of Pavia, Italy.

The interaction between spironolactone and dihydrotestosterone (DHT) receptors was evaluated with an autoradiographic technique. The inhibition of DHT receptors by spironolactone was found to be related to the decrease of tritiated DHT granules in the sebaceous glands of the treated site. 6 male patients affected by acne vulgaris entered the study. The acute study was performed by applying to 25 cm2 of the back a cream containing 5% spironolactone under occlusive dressing. The dosage of spironolactone applied was 4 mg/cm2 for 48 h. The long-term study was performed by applying the same amount to the entire back, without occlusion, twice daily for 1 month. Skin biopsies were taken at the end of the treatment, incubated with tritiated DHT and processed for autoradiography. Both the acute and the long-term study revealed a decrease of the autoradiographic granules in the treated site. This effect is related to the binding of spironolactone with dihydrotestosterone receptors in the sebaceous glands. Our study demonstrates that 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies.





Title: Re: topical spironolactone?
Post by: theworm on May 30, 2010, 05:51:49 PM
Recently there are studies (Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G.) which suggest that topical spironolactone can act as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labeled DHT. This means that topical spironolactone may slow down or stop hairloss by working as a DHT receptors blocker.
Title: Re: topical spironolactone?
Post by: kiwiol on May 30, 2010, 05:55:29 PM
Got any before / after pics of someone who's tried it? One pic speaks volumes more than a huge wall of text describing the science behind the cure, which doesn't always translate successfully from theory to result.
Title: Re: topical spironolactone?
Post by: Mr Nobody on May 30, 2010, 05:57:37 PM
No cure but a rug. ;D
Title: Re: topical spironolactone?
Post by: Mr Nobody on May 30, 2010, 06:07:52 PM
Geee! A new topical treatment!  ::)

Here's what you can do:


a. Shave your head
b. Keep your hair long, try to mask ur hairloss with weird hairdos.
c. Get a really expensive hairtransplant.
d. Get on fin/dut and hope for the best.
e. Get on these topical treatments (rogaine etc) and enjoy the thin whiskers you get from it.


b. I forgot about the "wrap around technique" nice call.
Title: Re: topical spironolactone?
Post by: devilsmile on May 30, 2010, 06:08:11 PM
oh you people are so behind the times  ::)

you only need to open up ur reptilian dna, you can control energy and everything is energy so if you want you can do anything you want, getting hair is nothing... we are all imagination of our selves, nothing rly is existing here, we are all just big concious  ::)

so that, getting hair, should be easy...  ::)
Title: Re: topical spironolactone?
Post by: Mr Nobody on May 30, 2010, 06:25:17 PM
Thats not kyomu.
Title: Re: topical spironolactone?
Post by: dustin on May 30, 2010, 06:36:59 PM
Never had this problem. My hair's so fucking thick and grows faster than bamboo. Problem is, I HATE having hair and have to shave my dome all the time!!
Title: Re: topical spironolactone?
Post by: Tito24 on May 30, 2010, 06:55:09 PM
Propecia does seem to work..However, the side effects are terrible.. :'(

Title: Re: topical spironolactone?
Post by: pluck on May 30, 2010, 07:03:53 PM
2 words for you.
Donald Trump.

Think about it. He's got billions & yet he still has the most amazing comb over ever.
Point is...even if Money isn't a problem there's nothing that can reverse hairloss.

Stop being deluded & just Bic your head.
Title: Re: topical spironolactone?
Post by: epic_alien on May 30, 2010, 09:34:25 PM
he is right,

nothing works for hairloss

plus if you try and slow it down with drugs

your cock will suffer

so up the dose and shave your head
Title: Re: topical spironolactone?
Post by: WillGrant on May 31, 2010, 04:26:01 AM
anyone use this for hair loss?

i read it decreased DHT in the scalp.   I tried rogaine, but it didn't do anything, and i am not ready to get on finasteride yet due to all the side effects.

opinions?
Worrying increases hair loss ...you worry alot
Title: Re: topical spironolactone?
Post by: Mr Nobody on May 31, 2010, 04:31:44 AM
allen pimp slappin hos wif his gat
PTPS.