Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Main Boards => Gossip & Opinions => Topic started by: Meso_z on July 02, 2011, 12:56:19 AM
-
Seriously, some of the biggest (+lean) guys I know, including a pro, or guys with respectable builts, who happen to be ripped too, are
heavy/moderate smokers.
Ive always wondered if smoking works as a appettite suppressant and is indirectly a fatburner...
Anyone from here smokes?
They always tell you that smoking is "bad" for bbing or alcohol for example..im sure each and every one of you here know at least one person who is considered an "exception" (drinks/smokes)
-
Seriously, some of the biggest (+lean) guys I know, including a pro, or guys with respectable builts, who happen to be ripped too, are
heavy/moderate smokers.
Ive always wondered if smoking works as a appettite suppressant and is indirectly a fatburner...
Anyone from here smokes?
They always tell you that smoking is "bad" for bbing or alcohol for example..im sure each and every one of you here know at least one person who is considered an "exception" (drinks/smokes)
His lungs are prolly effed up...no stamina on cardio day
-
Appetite supresses yes.
However I don't think it has any fatburning qualities. It restricts blood flow in the body. And make limbs colder. It does increase heart rate though. Not a doctor but this is what Ive gathered.
A shitty deal I'd say.
-
His lungs are prolly effed up...no stamina on cardio day
You are dumb as I previously stated. Many athletes in endurance sports smoke
-
Best bodybuilder in my gym smokes
I dont think it makes a differance to muscle
-
You are dumb as I previously stated. Many athletes in endurance sports smoke
name one...and I'm not talking about smoking weed...
name one athlete in edurance sports today (competing today) that are habitual smokers...
I know of several people who have lung cancer from habitual smoking, lungs filled up with tar...smoking hinders lung capacity...
Furthermore, i thought you were going to be more "positive" is that another one of your lies.
-
in fairness now, bodybuilding isnt an endurance sport
-
in fairness now, bodybuilding isnt an endurance sport
Yeh it is it takes years before someone realises you are a bodybuilder
-
Pulling out a packet of smokes is a great way to get rid of numpties who want to talk to me about what supplements I take to keep my abs so ripped and my "sit-up/crunch routine."
There should be a brand simply called Fuck Off.
-
Yeh it is it takes years before someone realises you are a bodybuilder
Haha true
-
Pulling out a packet of smokes is a great way to get rid of numpties who want to talk to me about what supplements I take to keep my abs so ripped and my "sit-up/crunch routine."
There should be a brand simply called Fuck Off.
This is s a great post man, seriously. ;D
-
who cares, smoking has too much disadvantages
-
almost every german bb is a smoker
esp. ruhl and wolf are big time smokers (every 5 minutes)
smoking makes the skin dryer/thinner and helps dieting
-
who cares, smoking has too much disadvantages
list them stud.
-
Smoking indeed diminishes appetite. That's why teenage girl tend to smoke more these days.
Theoretically it increases metabolism, so more fat gets burned.
It temporarily increases bloodsugar.
And you tend to die from it.
Says Doctor Dutch.
-
list them stud.
:-X
(http://cancertypes.tk/wp-content/uploads/2011/01/Lung-Cancer.jpg)
(http://www.smokinglung.org/wp-content/uploads/2010/11/Lung-Cancer-Cure.jpg)
-
Seriously, some of the biggest (+lean) guys I know, including a pro, or guys with respectable builts, who happen to be ripped too, are
heavy/moderate smokers.
Ive always wondered if smoking works as a appettite suppressant and is indirectly a fatburner...
Anyone from here smokes?
They always tell you that smoking is "bad" for bbing or alcohol for example..im sure each and every one of you here know at least one person who is considered an "exception" (drinks/smokes)
Yeah, I once saw a huge guy in Miami beach smoking. It has nothing to do with fat burning. Nicotine dramatically increases your ability to contract muscles due to stimulation of nicotinic acetylcholine receptors. This also relaxes your muscles which makes you feel a lot less pain. The release of dopamine in the nucleus accumbens region of the brain increases motivation, and the release of norepinephrine in the locus coerelus area of the brain increases determination. Unfortunately, nicotine in gum does not have the same effect, as it reaches the bloodstream a lot more slowly than when you inhale tobacco smoke.
SUCKMYMUSCLE
-
list them stud.
;D
-
Yeah, I once saw a huge guy in Miami beach smoking. It has nothing to do with fat burning. Nicotine dramatically increases your ability to contract muscles due to stimulation of nicotinic acetylcholine receptors. This also relaxes your muscles which makes you feel a lot less pain. The release of dopamine in the nucleus accumbens region of the brain increases motivation, and the release of norepinephrine in the locus coerelus area of the brain increases determination. Unfortunately, nicotine in gum does not have the same effect, as it reaches the bloodstream a lot more slowly than when you inhale tobacco smoke.
SUCKMYMUSCLE
That's right, Bokito. You googled this or are you an expert or what ?
-
Many folks smoke - and many happen to go to the gym. One gym I used to train always had people light up their cig right after a workout.
I smoke from 3 - 10 cigs a day and it clearly isn't a good thing, but not as serious as some folks make it out to be.
If you haven't started already - stay away.
-
I smoke a pack a day(not bragging, it's a disgusting habit) and I destroy any kind of cardio , no prob. 6'1" 210lbs pretty ripped right now
-
JWOWW takes a few puffs after a good workout!
(http://i.fitperez.com/wp-content/uploads/2011/06/jwowwsnookigymhome__oPt.jpg)
-
filthy habbit that next needs to be banned for use anywhere in public..
anyway, there was a stink up a bit back when it was discovered that wayne rooney smokes. zidane smoked. infact loads of footballers, and athletes smoke. serge blanco was a chain smoker.
-
JWOWW takes a few puffs after a good workout!
(http://i.fitperez.com/wp-content/uploads/2011/06/jwowwsnookigymhome__oPt.jpg)
Marcie Runkle looking lubricated.
-
name one...and I'm not talking about smoking weed...
name one athlete in edurance sports today (competing today) that are habitual smokers...
I know of several people who have lung cancer from habitual smoking, lungs filled up with tar...smoking hinders lung capacity...
Furthermore, i thought you were going to be more "positive" is that another one of your lies.
fuck off midget
I smoked while playing professional tenis plus I met a plethora of pro athletes who smoked
Jonathan Power former world no 1 in Squash smoked and obviously it did not hider him ... hell.... I even met a top 20 marathon runner who smoked 10 a day
stick to car magazines boy
-
fuck off midget
I smoked while playing professional tenis plus I met a plethora of pro athletes who smoked
Jonathan Power former world no 1 in Squash smoked and obviously it did not hider him ... hell.... I even met a top 20 marathon runner who smoked 10 a day
stick to car magazines boy
And look how far you went....
Did j. Power do it while playing squash...and squash is not a constant enduro, old men play squash, so even of J Power did, he could get away with it. What next, you gonna claim you know golf players who smoke?
And top 20 marathoner, please, did they do it when they were training or running.
I ran track in HS, and the dudes who smoked and tried out were gasping for breath. It's a proven fact that
smoking constricts lung capacity...stick to reptilians and telling people their fortune... Quit being contrite.
-
Smokers should have the common sense to not affect non smokers when they smoke.
That being said,there's a world wide war going against people who make the personal choice to smoke.
It's purpose must be to have sheeple marginalizing other sheeple as a group, and to accept the legal punishment of sheeple for an act of personal choice that doesn't affect others, in this preparing the terrain for future punishments of non criminal acts by sheeple.
-
Seriously, some of the biggest (+lean) guys I know, including a pro, or guys with respectable builts, who happen to be ripped too, are
heavy/moderate smokers.
Ive always wondered if smoking works as a appettite suppressant and is indirectly a fatburner...
Anyone from here smokes?
They always tell you that smoking is "bad" for bbing or alcohol for example..im sure each and every one of you here know at least one person who is considered an "exception" (drinks/smokes)
smoking and drinking are both fine for bodybuilding. watch the calories in the mixed driks tho.
-
in their hey day,both texas outlaws,dick murdoch and the american dream,stardust himself,dusty rhodes both smoked.
-
7/8 of all pro bodybuilders smoke pole :-\
-
smoking and drinking are both fine for bodybuilding. watch the calories in the mixed driks tho.
A sargeant who shall remain unnamed because I forgot it told me at a party on Fort Hood, "The US Army is the biggest collection of physically fit smokers and alcoholics on the planet."
-
Markus Ruhl and many European bodybuilders smoke like trains. They were raised that way.
Age limitations are not the same in other countries. They start earlier and legally.
-
Markus Ruhl and many European bodybuilders smoke like trains. They were raised that way.
Age limitations are not the same in other countries. They start earlier and legally.
Most Europeans smoke. ;)
-
Smoking indeed diminishes appetite. That's why teenage girl tend to smoke more these days.
Theoretically it increases metabolism, so more fat gets burned.
It temporarily increases bloodsugar.
And you tend to die from it.
Says Doctor Dutch.
Wrong. They smoke because they think they look cool.
-
Wrong. They smoke because they think they look cool.
Isn't that what everyone thinks? ???
-
Isn't that what everyone thinks? ???
In college seemed like everyone smoked. At least socially.
Great ice breaker girls.
Also to surpress appetite with cigarettes, it takes almost a pack a day.
I know because I was a heavy smoker until I got disgusted with myself & quit.
People make too much of a big deal about smoking. Who gives a fuck.
Alcohol, burgers & fries, sedeate lifestyle, ... Are all shitty for ones health & nobody talk about that.
-
In college seemed like everyone smoked. At least socially.
Great ice breaker girls.
Also to surpress appetite with cigarettes, it takes almost a pack a day.
I know because I was a heavy smoker until I got disgusted with myself & quit.
People make too much of a big deal about smoking. Who gives a fuck.
Alcohol, burgers & fries, sedeate lifestyle, ... Are all shitty for ones health & nobody talk about that.
there teeth are so yellow. :-\ :-X Man, gum does not help women out. :-\ It's like licking a ash tray. Fuck that. :-X
-
Best bodybuilder in my gym smokes
I dont think it makes a differance to muscle
Do you know why? They are addicted. They are those poor son of the bitches who has addiction to nicotine and they have no options. And yes, there is a rumor that nicotine has some kind of positive edge to building mass, but in the real life it is really so small, that the toxic in the tobacco eat all the benefits of it. If you are able to think, you understand that after workout your body is screaming for oxygen, and if you smoke, you fill your system with the carbon monoxide and thousands of toxic chemicals from the tobacco, so it isn't just same as oxygen what your body really needs at the moment.
Name 1 benefit of smoking, which has been scientifically proven, and with the link, please. ??? Not find any? Tobacco is no good, there isn't anything good in it, but in the long run, it will kill you one way or another. And before you start to arguments like "my grandpa smoke 100 years and died by the stroke of lightning", try to understand this little fact: Those old geezers in your arguments has been living in this world before the nuclear waste, before the DDT, before all the pollution which you are sucking in your lungs with the tobacco. When your grandpa was young, pollution was different, like smell of the horse shit on the field. You understand the difference? When you was born, your mother feed you with the milk with DDT in it. Petrol on the car which he drive you to the school, has lead in it. There was asbestos in the brakes and in the building materials and in these years you have suck all that shit in you, and then smoke? More than 5000 chemicals, including many which would kill you by themselves by doses less than 1 gram. There is no point at all to smoking.
-
there teeth are so yellow. :-\ :-X Man, gum does not help women out. :-\ It's like licking a ash tray. Fuck that. :-X
I avoid girls who smoke like the plague.
I feel disgusted when we get close and they smell cigs and whiskey.
-
And look how far you went....
Did j. Power do it while playing squash...and squash is not a constant enduro, old men play squash, so even of J Power did, he could get away with it. What next, you gonna claim you know golf players who smoke?
And top 20 marathoner, please, did they do it when they were training or running.
I ran track in HS, and the dudes who smoked and tried out were gasping for breath. It's a proven fact that
smoking constricts lung capacity...stick to reptilians and telling people their fortune... Quit being contrite.
you are such a dumb fuck trust me
squash is one of the most brutal endurance sports where you start and stop non stop.. obviously you don't know jack shit about athletics
yes. he smoked when he was on top... so did others in other sports
point is you love to argue but have no clue ....
keep reading them car magazines and the FUBU weekly for "urban" news and trends pfffff
-
Do you smoke sev?
-
Do you smoke sev?
I quit
but I smoked while training hard and playing ... it's about addiction it has no value to what you do... you loose some VO max when smoking
I don't recommend it
-
you are such a dumb fuck trust me
squash is one of the most brutal endurance sports where you start and stop non stop.. obviously you don't know jack shit about athletics
yes. he smoked when he was on top... so did others in other sports
point is you love to argue but have no clue ....
keep reading them car magazines and the FUBU weekly for "urban" news and trends pfffff
Sure it is...ok Sev, seems like you smoking some high quality stuff...
let me go DC tomorrow and tell the dudes on the courts playing streetball that they need to play "squash" because it's far more demanding than playing half court basketball in 90 degree heat.
I went to a gym that had a squash and racquetball courts---it's not as physically demanding as you say--most of the people playing are either overweight or old
And you have no poof that he did, only your word, which is not much, because are prone to lying.
Sev, the only sport you know about is Tennis...
I grew up playing basketball, baseball, and ran track in HS and have siblings that played soccer and lacrosse. Sports Illustrated was one of my favorite mags, not any car magazines.
Fact of the matter is, yes some athletes smoke, even though they know that they are not suppose to...the reasons are probably because they are addicted
But it is a proven fact that you cannot dispute that smoking hinders lung capacity, and for endurance sports one needs all the air one can get.
Also, African Amercan children are more prone to get asthma from secondhand smoke than any other. I personally know of people who have had secondhand smoke as as child and have had asthma as result and reduced breathing capcity.
So, you need to stop with your bullshit, just to justify your own bad habits or addictions. First thing you do is call names, which shows you don't have leg to stand on, as you cannot engage in a argument, w/o calling names first.
-
you are so stupid .. you compare the squash you play wih the squash played at the highest level lol
what's next? tennis is easy cause you played and it's not too demanding? you are a playground rat nothing more son
find some common sense then come back
-
you are so stupid .. you compare the squash you play wih the squash played at the highest level lol
what's next? tennis is easy cause you played and it's not too demanding?
find some common sense then come back
Bullshit, the first thing you do is insult a person's intelligence...odd how, the one thing that you lack, you keep insulting others for lacking...I find it quit entertaining.
i never said I played it, but others play...they have a league...
You should know that many times intensity is a persona thing and sports like Football, basketball, soccer, track and field, tennis, people give their all at all levels of the game. Period. if you gonna compete then you gotta give it your all, especially if you want to be on the team...that's the common sense...I didn't need to find, but something that you lost.
-
again .. you compare top level squash with buddies with friends who's cousins play ion a local league
I played 5.5 level tournaments and a couple of 6.0 qualies in squash .... it's night and day my friend
you were a mediocre athlete and it shows .. listen to yourself .. comparing top level squash with some loser accountants and never were who play locally
-
again .. you compare top level squash with buddies with friends who's cousins play ion a local league
I played 5.5 level tournaments and a couple of 6.0 qualies in squash .... it's night and day my friend
you were a mediocre athlete and it shows .. listen to yourself .. comparing top level squash with some loser accountants and never were who play locally
speaking of yourself again?
And, loser accountants---how are you gonna call someone a loser who has a degree and a job making more money than you'll ever see scamming parents of mentally handicap kids...
You were speaking of intesity...and again, I never said that they were buddies, friends or cousins, where pull that out of your ass (like everything else).
You are a jealous, conceded, asinine hypocrite with a Lilliputian mind and imgaination. You seek to validate yourself thru insults and trying one up everbody. You are a washed roid user who is jealous of anybody who has accomplished more than you, has more than you, looks better than you. Or those who are geniunely happy. And it always shows in the first sentence of all of your posts when someone disagrees with you...
You need to stick playing with tarot cards, or will you get mad if you find out someone is better than you at that?
-
Yes im smoker, and im smoking right now as i type this, as far as training goes, i notice when i do barbell curls, i dont have enough air, and grasping for it, all other exercizes are fine, cardio no problem too, not that i do cardio.
-
there teeth are so yellow. :-\ :-X Man, gum does not help women out. :-\ It's like licking a ash tray. Fuck that. :-X
But the hottest chicks almost always smoke. Even ones you wouldn't expect, like Anne Hathaway and Natalie Portman.
I'd rather fuck the ever-living shit out of a gorgeous smoker than pound some clean-living butherface.
-
Isn't that what everyone thinks? ???
In the beginning... not when they get older and realize what it has done to them... then they try and hide it.... and can't. Funny how that works.
-
In the beginning... not when they get older and realize what it has done to them... then they try and hide it.... and can't. Funny how that works.
Lemme see here:
Walls turn yellow.
Teeth turn yellow.
they have that delightful cough and blame it on something else besides smoking.
The house smells like shit!
It's the biggest turnoff when i see a chick smoking. >:(
-
Turnoff ?
-
Smoking actually increases cortisol which is linked to stomach fat. I know. Before i smoked I was lean in the stomach and now have a little bit of fat there, but rest of me is still very lean.
-
Lemme see here:
Walls turn yellow.
Teeth turn yellow.
they have that delightful cough and blame it on something else besides smoking.
The house smells like shit!
It's the biggest turnoff when i see a chick smoking. >:(
I drink tons of coffee and smoke half pack a day and always complimented on my white teeth. U need to know how to take care of yourself. I don't smoke in my house either. It's dirty and want to stop but it's very rewarding LOL
-
:)
-
one of the main reasons i quit smoking was because it seems like the only people left smoking in the world are eastern europeans and black crackheads, neither of which i want to be associated with in any way. (yes, i realize i'm eastern european, but no need to add to my shittiness)
-
I drink tons of coffee and smoke half pack a day and always complimented on my white teeth. U need to know how to take care of yourself. I don't smoke in my house either. It's dirty and want to stop but it's very rewarding LOL
(http://homedailynews.com/wp-content/uploads/2011/01/smoking1.jpg)
I know some chicks down here that go through two-three packs of Marlboro Reds in a day. :o
-
I dig chicks that smoke
-
I dig chicks that smoke
(http://4.bp.blogspot.com/_iEq7wOCrrMk/S-hk2n8rD6I/AAAAAAAAABw/de685AKW3oc/s1600/755_marlboro.JPG)
:o
-
one of the main reasons i quit smoking was because it seems like the only people left smoking in the world are eastern europeans and black crackheads, neither of which i want to be associated with in any way. (yes, i realize i'm eastern european, but no need to add to my shittiness)
America is full of white trash that is keeping the tobacco companies profitable. There's also a decent percentage of closet smokers in the upper class of America.
-
"my grandpa smoke 100 years and died by the stroke of lightning", try to understand this little fact: Those old geezers in your arguments has been living in this world before the nuclear waste, before the DDT, before all the pollution which you are sucking in your lungs with the tobacco.
No, this is not the reason why this is a terrible argument. The reason why it is a terrible argument is due to the existence of something called statistical averages. Sure, there is a 100 year-old guy out there who smoked 2 packs a day for 60 years and died of something other than complications caused by tobbacco. Jean-Louis Calment, the oldest Human ever, who died at 122, smoked for 50 years. The problem is that, on average, smokers live a lot less than non-smokers(18 years less) and have much lower quality of life in their older years than non-smokers. A 20 year-old who smokes has great quality of life due to his youth and vitality. At 40 the difference in quality of life between smokers and non-smokers is still small but noticeable. But at 60, between two guys, one who is a smoker and the other a non-smoker, the non-smoker will have a much higher quality of life. The 60 year-old who smokes will get short-breathed after walking a hundred yards or climbing two flights of stairs. He will feel nausea and brutal headaches all day long because at 60, your body simply cannot clear the toxins in tobbacco as fast as it could at age 20, so they accumulate causing these problems, and because a 60 year-old has been smoking a lot longer than a 0 year-old, so there is simply too much toxins for the body to clean. The fundamental problem with tobbacco is that it shortens your life and makes the last couple decades of your life hell. It makes you difference at all at age 30. Smoking is actually very pleasurable. It is up to individuals to decide if the cost/benefit is worth it.
SUCKMYMUSCLE
-
Smoking actually increases cortisol which is linked to stomach fat. I know. Before i smoked I was lean in the stomach and now have a little bit of fat there, but rest of me is still very lean.
didn't know about this ???
-
people get into bodybuilding either to be healthy or to look better
smoking affects both in a negative way
E
-
Turnoff ?
well of course your still gonna fuck her hard.. but the rancid smell of cigarette smoke doesn't care how pretty you are. you're still gonna stink
(http://www.getbig.com/boards/index.php?action=dlattach;topic=387655.0;attach=419327)
-
people get into bodybuilding either to be healthy or to look better
smoking affects both in a negative way
E
Yes, but nicotine dramatically increases your ability to train harder, which often results in bigger muscles. It depends on what you consider to be looking better. For a gym rat, having big muscles is much more important than having silky hair and a beautiful complexion. If nicotine might help him achieve that, it might be worth it to him in his mind.
SUCKMYMUSCLE
-
Nicotine is an aromatase inhibitor, which keeps estrogen levels lower. It can also increase DHT levels. I guess these side effects can possibly benefit bodybuilders.
I dare you to prove this.
-
I dare you to prove this.
Ok
Tobacco alkaloid derivatives as inhibitors of breast cancer aromatase.
Kadohama N, Shintani K, Osawa Y.
Endocrine Biochemistry Department, Medical Foundation of Buffalo Research Institute, N.Y. 14203.
The inhibition of estrogen biosynthesis by the use of aromatase inhibitors is emerging as a valuable approach to breast cancer therapy. Because smoking has a profound effect on estrogen-related processes we examined the ability of tobacco constituents to suppress estrogen production by breast cancer aromatase. N-n-octanoylnornicotine and N-(4-hydroxyundecanoyl) anabasine suppressed aromatase activity in culture of two human breast cancer cell lines, MDA-MB-231 (IC50 of 310 and 20 microM, respectively) and SK-BR-3 (IC50 of 450 and approximately 2 microM, respectively). MDA-MB-231 cells induced by 250 nM dexamethasone or 1 mM (Bt)2cAMP were slightly more sensitive to both inhibitors. Kinetic analyses showed that inhibition by N-(4-hydroxyundecanoyl)anabasine is competitive with respect to androstenedione as substrate, with apparent Ki values of 0.2 microM against microsomal aromatase activity derived from both (Bt)2cAMP-induced MDA-MB-231 cells and human breast tumor tissue. The corresponding apparent Ki against human placental microsomal aromatase activity was 0.4 microM. These results indicate that acyl derivatives of nornicotine and anabasine block estrogen formation in breast tumor cells and tissue and could contribute to the decreased intra-tissue estrogen levels in women who smoke.
PMID: 8313352 [PubMed - indexed for MEDLINE]
1: Endocr Res. 1991;17(3-4):409-19.Related Articles, Links
Competitive inhibition of human placental aromatase by N-n-octanoylnornicotine and other nornicotine derivatives.
Bullion K, Ohnishi S, Osawa Y.
Endocrine Biochemistry Department, Medical Foundation of Buffalo Research Institute, NY 14203.
In a study of the effect of N-n-octanoylnornicotine and other acyl derivatives of nornicotine on the aromatization of androstenedione by human placental microsomal aromatase, we found that N-n-octanoylnornicotine, a component of cigarette smoke, exhibited competitive inhibition with an apparent Ki of 0.65 microM. This is comparable to that of aminoglutethimide, the clinically-used non-steroidal aromatase inhibitor. N-n-Decanoylnornicotine and N-(4-hydroxyundecanoyl)nornicotine exhibited apparent Ki values of 0.86 microM and 0.24 microM, respectively. This study suggests that cigarette smoke components may have a direct effect on estrogen biosynthesis and that these compounds may prove to be useful parent structures for development of active site probes for further elucidation of estrogen biosynthesis and might eventually lead to the development of alternative non-steroidal anti-cancer therapy.
PMID: 1811989 [PubMed - indexed for MEDLINE]
Nicotine and estrogen metabolism--possible implications of smoking for growth and outcome of treatment of hormone-dependent cancer? Discussion of experimental results.
Zeller WJ, Berger MR.
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
The combination treatment of hormone-dependent autochthonous mammary carcinomas in the rat with nicotine plus HECNU, a water-soluble nitrosourea, resulted in a potentiation of antitumor action. Nicotine and its metabolite cotinine are strong inhibitors of the aromatase. With regard to investigations in smoking women, suggesting a decreased endogenous estrogen production, our results indicate that smoking might influence growth and treatment results of hormone-dependent human cancer.
PMID: 2606936 [PubMed - indexed for MEDLINE]
Fertil Steril. 1986 Aug;46(2):232-6.Related Articles, Links
Constituents of cigarette smoke inhibit human granulosa cell aromatase.
Barbieri RL, McShane PM, Ryan KJ.
Recent epidemiologic studies suggest that women smokers have lower endogenous estrogen levels than nonsmokers. The effects of aqueous extracts of cigarette smoke on aromatase were evaluated in cultures of human granulosa cells. Aqueous extracts of cigarette smoke inhibited the conversion of androstenedione (delta 4A) to estradiol in a dose-dependent manner. Dialysis experiments demonstrated that 90% of the inhibitory activity of aqueous extracts of cigarette smoke was in the less than 1000 mol wt fraction. Removal of the aqueous extract of cigarette smoke from the culture medium resulted in a complete reversal of the inhibition of delta 4A aromatization. Addition of supraphysiologic concentrations of delta 4A (73 microM) to the culture medium blocked the smoke-induced inhibition of aromatization. Two low-molecular-weight components of cigarette smoke, nicotine and anabasine, inhibited granulosa cell aromatase in a dose-dependent manner. These studies suggest that constituents of cigarette smoke inhibit a major steroidogenic pathway.
J Clin Invest. 1986 Jun;77(6):1727-33.Related Articles, Links IPB Image
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
Barbieri RL, Gochberg J, Ryan KJ.
Epidemiologic studies suggest that women who smoke have lower endogenous estrogen than nonsmokers. To explore the possible link between cigarette smoking and decreased endogenous estrogens, we have examined the effects of constituents of tobacco on estrogen production in human choriocarcinoma cells and term placental microsomes. In choriocarcinoma cell cultures, nicotine, cotinine (a major metabolite of nicotine), and anabasine (a minor component of cigarette tobacco) all inhibited androstenedione conversion to estrogen in a dose-dependent fashion. Removal of nicotine, cotinine, and anabasine from the culture medium resulted in the complete reversal of the inhibition of aromatase. In the choriocarcinoma cell cultures, a supraphysiologic concentration of androstenedione (73 microM) in the culture medium blocked the inhibition of aromatase caused by nicotine, cotinine, and anabasine. In preparations of term placental microsomes, nicotine, cotinine, and anabasine inhibited the conversion of testosterone to estrogen. Kinetic analysis demonstrated the inhibition to be competitive with respect to the substrate. These findings suggest that some nicotinic alkaloids directly inhibit aromatase. This mechanism may explain, in part, the decreased estrogen observed in women who smoke.
PMID: 3711333 [PubMed - indexed for MEDLINE]
-
Yeah, I once saw a huge guy in Miami beach smoking. It has nothing to do with fat burning. Nicotine dramatically increases your ability to contract muscles due to stimulation of nicotinic acetylcholine receptors. This also relaxes your muscles which makes you feel a lot less pain. The release of dopamine in the nucleus accumbens region of the brain increases motivation, and the release of norepinephrine in the locus coerelus area of the brain increases determination. Unfortunately, nicotine in gum does not have the same effect, as it reaches the bloodstream a lot more slowly than when you inhale tobacco smoke.
SUCKMYMUSCLE
hence the reason for a fatty dip pre-workout!
-
Ok
Tobacco alkaloid derivatives as inhibitors of breast cancer aromatase.
Kadohama N, Shintani K, Osawa Y.
Endocrine Biochemistry Department, Medical Foundation of Buffalo Research Institute, N.Y. 14203.
The inhibition of estrogen biosynthesis by the use of aromatase inhibitors is emerging as a valuable approach to breast cancer therapy. Because smoking has a profound effect on estrogen-related processes we examined the ability of tobacco constituents to suppress estrogen production by breast cancer aromatase. N-n-octanoylnornicotine and N-(4-hydroxyundecanoyl) anabasine suppressed aromatase activity in culture of two human breast cancer cell lines, MDA-MB-231 (IC50 of 310 and 20 microM, respectively) and SK-BR-3 (IC50 of 450 and approximately 2 microM, respectively). MDA-MB-231 cells induced by 250 nM dexamethasone or 1 mM (Bt)2cAMP were slightly more sensitive to both inhibitors. Kinetic analyses showed that inhibition by N-(4-hydroxyundecanoyl)anabasine is competitive with respect to androstenedione as substrate, with apparent Ki values of 0.2 microM against microsomal aromatase activity derived from both (Bt)2cAMP-induced MDA-MB-231 cells and human breast tumor tissue. The corresponding apparent Ki against human placental microsomal aromatase activity was 0.4 microM. These results indicate that acyl derivatives of nornicotine and anabasine block estrogen formation in breast tumor cells and tissue and could contribute to the decreased intra-tissue estrogen levels in women who smoke.
PMID: 8313352 [PubMed - indexed for MEDLINE]
1: Endocr Res. 1991;17(3-4):409-19.Related Articles, Links
Competitive inhibition of human placental aromatase by N-n-octanoylnornicotine and other nornicotine derivatives.
Bullion K, Ohnishi S, Osawa Y.
Endocrine Biochemistry Department, Medical Foundation of Buffalo Research Institute, NY 14203.
In a study of the effect of N-n-octanoylnornicotine and other acyl derivatives of nornicotine on the aromatization of androstenedione by human placental microsomal aromatase, we found that N-n-octanoylnornicotine, a component of cigarette smoke, exhibited competitive inhibition with an apparent Ki of 0.65 microM. This is comparable to that of aminoglutethimide, the clinically-used non-steroidal aromatase inhibitor. N-n-Decanoylnornicotine and N-(4-hydroxyundecanoyl)nornicotine exhibited apparent Ki values of 0.86 microM and 0.24 microM, respectively. This study suggests that cigarette smoke components may have a direct effect on estrogen biosynthesis and that these compounds may prove to be useful parent structures for development of active site probes for further elucidation of estrogen biosynthesis and might eventually lead to the development of alternative non-steroidal anti-cancer therapy.
PMID: 1811989 [PubMed - indexed for MEDLINE]
Nicotine and estrogen metabolism--possible implications of smoking for growth and outcome of treatment of hormone-dependent cancer? Discussion of experimental results.
Zeller WJ, Berger MR.
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
The combination treatment of hormone-dependent autochthonous mammary carcinomas in the rat with nicotine plus HECNU, a water-soluble nitrosourea, resulted in a potentiation of antitumor action. Nicotine and its metabolite cotinine are strong inhibitors of the aromatase. With regard to investigations in smoking women, suggesting a decreased endogenous estrogen production, our results indicate that smoking might influence growth and treatment results of hormone-dependent human cancer.
PMID: 2606936 [PubMed - indexed for MEDLINE]
Fertil Steril. 1986 Aug;46(2):232-6.Related Articles, Links
Constituents of cigarette smoke inhibit human granulosa cell aromatase.
Barbieri RL, McShane PM, Ryan KJ.
Recent epidemiologic studies suggest that women smokers have lower endogenous estrogen levels than nonsmokers. The effects of aqueous extracts of cigarette smoke on aromatase were evaluated in cultures of human granulosa cells. Aqueous extracts of cigarette smoke inhibited the conversion of androstenedione (delta 4A) to estradiol in a dose-dependent manner. Dialysis experiments demonstrated that 90% of the inhibitory activity of aqueous extracts of cigarette smoke was in the less than 1000 mol wt fraction. Removal of the aqueous extract of cigarette smoke from the culture medium resulted in a complete reversal of the inhibition of delta 4A aromatization. Addition of supraphysiologic concentrations of delta 4A (73 microM) to the culture medium blocked the smoke-induced inhibition of aromatization. Two low-molecular-weight components of cigarette smoke, nicotine and anabasine, inhibited granulosa cell aromatase in a dose-dependent manner. These studies suggest that constituents of cigarette smoke inhibit a major steroidogenic pathway.
J Clin Invest. 1986 Jun;77(6):1727-33.Related Articles, Links IPB Image
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
Barbieri RL, Gochberg J, Ryan KJ.
Epidemiologic studies suggest that women who smoke have lower endogenous estrogen than nonsmokers. To explore the possible link between cigarette smoking and decreased endogenous estrogens, we have examined the effects of constituents of tobacco on estrogen production in human choriocarcinoma cells and term placental microsomes. In choriocarcinoma cell cultures, nicotine, cotinine (a major metabolite of nicotine), and anabasine (a minor component of cigarette tobacco) all inhibited androstenedione conversion to estrogen in a dose-dependent fashion. Removal of nicotine, cotinine, and anabasine from the culture medium resulted in the complete reversal of the inhibition of aromatase. In the choriocarcinoma cell cultures, a supraphysiologic concentration of androstenedione (73 microM) in the culture medium blocked the inhibition of aromatase caused by nicotine, cotinine, and anabasine. In preparations of term placental microsomes, nicotine, cotinine, and anabasine inhibited the conversion of testosterone to estrogen. Kinetic analysis demonstrated the inhibition to be competitive with respect to the substrate. These findings suggest that some nicotinic alkaloids directly inhibit aromatase. This mechanism may explain, in part, the decreased estrogen observed in women who smoke.
PMID: 3711333 [PubMed - indexed for MEDLINE]
OK, let's smoke, get big, then die at 50.
-
I smoke weed everyday and I'm NPC national top amateur
-
A sargeant who shall remain unnamed because I forgot it told me at a party on Fort Hood, "The US Army is the biggest collection of physically fit smokers and alcoholics on the planet."
You're quite right, my friend. I did too when I was in the military (ex-airborne here 1985-1993, deployments to Bosnia & Croatia), BUT was very quick to quit both when I got out... your health is your only possession. ;)