Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Main Boards => Gossip & Opinions => Topic started by: farrellzach on November 29, 2011, 08:38:44 AM
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Very clean feeling, no sweating like I've gotten with other products.
I'll hit another 5iu before bed and then it's off to the races.
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::)
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I bet you've already checked yourself out in the mirror for at least 5 times :D
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I bet you've already checked yourself out in the mirror for at least 5 times :D
hahaha.. ill second that ;D
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Very clean feeling, no sweating like I've gotten with other products.
I'll hit another 5iu before bed and then it's off to the races.
stop it right there!
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Elfy?
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I bet you've already checked yourself out in the mirror for at least 5 times :D
Nope, figured I'd give myself an hour and some carbs first
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Nope, figured I'd give myself an hour and some carbs first
You dirty liar you...
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I bet you've already checked yourself out in the mirror for at least 5 times :D
he shoud becaus starting in few hours muscle start expend and thats when no need for tank top anymore ,, he will feel the muscle is pop through shirt good enough to wear 3 xl and look like bodybuild,, its pharm grade gh ,, everything will pop within 14 day to a point he will loolk extremly impresive,, 14 days! not 14 weekslol
gh15 approved
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on 5 iu may take 20 days,, but prety much it start from first inject,, it is diff feel remember this feel it doenst come easy now day with all the junk around
gh15 approved
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he shoud becaus starting in few hours muscle start expend and thats when no need for tank top anymore ,, he will feel the muscle is pop through shirt good enough to wear 3 xl and look like bodybuild,, its pharm grade gh ,, everything will pop within 14 day to a point he will loolk extremly impresive,, 14 days! not 14 weekslol
gh15 approved
Looking forward to the changes.
10iu a day should be good!
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he shoud becaus starting in few hours muscle start expend and thats when no need for tank top anymore ,, he will feel the muscle is pop through shirt good enough to wear 3 xl and look like bodybuild,, its pharm grade gh ,, everything will pop within 14 day to a point he will loolk extremly impresive,, 14 days! not 14 weekslol
gh15 approved
Talking about GH. Have you ever used/heard of "Dynatrope"? It's pretty poppular where I'm from, and not much of other brands are available locally, besides Jin, which was legit maybe 4years ago.
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on 5 iu may take 20 days,, but prety much it start from first inject,, it is diff feel remember this feel it doenst come easy now day with all the junk around
gh15 approved
gh15 why broscience says that you really have the benefits of gh at 6 months mark in general ? You actually says it kicks much faster is it because of legit products / 10+iu ?
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gh15 why broscience says that you really have the benefits of gh at 6 months mark in general ? You actually says it kicks much faster is it because of legit products / 10+iu ?
many reason,, some realuy dont consider change until they look like bodybuild 2 weeks out lol this take 6 months usualy...but who want to walk around 2 week out from competition ,, most bodybuild want to look 4-8 week out on regular basis 1-2 week out is just not hwat you want,, also everything with time improve with gh,,,changes start within first minute gh in blod,, you see them within hours ....but! the moe you on the more you will see especialy since many now day work with underdose product,, and under pure product,, and it take longer time to build in blood,, inaddidition to the fact many start gh when they are 20% bodyfat or 15% and it take longer to see the bodybuild polish look when yuo start 15% take about 3 months...when someone who start 9% see it within weeks
gh15 approved
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Thank you for the answer gh15,
Guess I'll have to try it in the future.
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I've witnessed with my own eyes how someone started at about 225lb (at 6'1) single digit, and ended up 270 in a BETTER condition after about two to three months, running 15iu/day of gh + deca + mast+ test and I dare to say - even without tren. Tho' I should mention that that person was up to a similar weight like a year before that second transformation (and when the weight dropped - training was minimal and completely no stuff in the blood for that period of time), maybe that had something to do with it working so fast. Needless to say - it went away as fast as it came..
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WHOSE KIGS ARE THESE?
K OR DL.
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WHOSE KIGS ARE THESE?
K OR DL.
K
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K
GOOD JOB ELF. KEEP US UPDATED.
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I just injected my first 3 iu of thanktropin. Will report back.
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K
you will not be dissapointed bro.... quality HGH coming from K.
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you will not be dissapointed bro.... quality HGH coming from K.
THE CHAMP HAS SPOKEN.
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f
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::)
:D
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There's a lot of jentropin going round here anyone heard of that?
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you will not be dissapointed bro.... quality HGH coming from K.
I'm definitely looking forward to it, B.
Like I said earlier, I think 10iu will be more than enough to push me way past what I ever thought I would be able to accomplish.
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GOOD JOB ELF. KEEP US UPDATED.
Definitely will do. Taking the next year and growing as much as possible.
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Very clean feeling, no sweating like I've gotten with other products.
I'll hit another 5iu before bed and then it's off to the races.
Why would you sweat from one shot of gh??? What other products are u talking about?
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I remember it like it was yesterday. I only did 5 iu's of the kigs and literally started getting drowsy right afterwards (about 5 minutes). Next thing I knew I started getting the oh are you getting ready to compete comments and I'm confused because I'm in the middle of bulking right now.
Needless to say, now I've run out and have to get more :(
By the way, is it honestly worth it to go up to 275 if you only compete around 220. I've constantly hear the importance of staying close to contest weight in the offseason but just figured i'd ask on here...
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you will not be dissapointed bro.... quality HGH coming from K.
damn.. thought your rats did lab tests from GD?
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Why would you sweat from one shot of gh??? What other products are u talking about?
Used lots of cheap generics that I assume had some insulin in the vial, which mde me go hypo.
With the Kigs, this hasn't happened.
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Also
Lately tren insomnia has been awful. Last night was much better, but not amazing. I'm assuming it may be placebo, but it felt damn good to get a decent nights sleep.
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damn.. thought your rats did lab tests from GD?
all gear comes from GD, gh comes from various sources.
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Used lots of cheap generics that I assume had some insulin in the vial, which mde me go hypo.
With the Kigs, this hasn't happened.
this can happen after a GH shot. it does feel like insulin which is probably why some scammers will sell insulin as hgh!
the reason you may not have got it after your shot is the disturbance of a current insulin spike already happening in your body proabbly from your last meal. gh and insulin arnt the best of friends. a bigger gh spike will be with the presence of little to no insulin around and this is when you can go hypo after a gh shot as it lowers the blood glucose even more that you start to get shaky and sweat.
i should make clear though, that with such a legit product as the kigs you got, there is no need to "time" your shots according to your last carb meal or a current insulin spike as the shit will work regardless.
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Kigs from Kamikazi???
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Kigs from Kamikazi???
Si
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Very clean feeling, no sweating like I've gotten with other products.
I'll hit another 5iu before bed and then it's off to the races.
sweating? whatever you got before wasn't gh, lol
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Why are you jumping to 10iu? If Gh15's elves are correct then 5 should already feel like 10, so 10 would be 20 and unless you're a pro 20 may be overkill.
You can save money and spread it out a little longer with just 5 a day.
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Why are you jumping to 10iu? If Gh15's elves are correct then 5 should already feel like 10, so 10 would be 20 and unless you're a pro 20 may be overkill.
You can save money and spread it out a little longer with just 5 a day.
Let's just say I get a very good deal on bulk orders.
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this can happen after a GH shot. it does feel like insulin which is probably why some scammers will sell insulin as hgh!
the reason you may not have got it after your shot is the disturbance of a current insulin spike already happening in your body proabbly from your last meal. gh and insulin arnt the best of friends. a bigger gh spike will be with the presence of little to no insulin around and this is when you can go hypo after a gh shot as it lowers the blood glucose even more that you start to get shaky and sweat.
i should make clear though, that with such a legit product as the kigs you got, there is no need to "time" your shots according to your last carb meal or a current insulin spike as the shit will work regardless.
VERY VERY VERY VR VERY VERY GOOD POSTING!! ,, everything true 100%
gh15 approved
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Why are you jumping to 10iu? If Gh15's elves are correct then 5 should already feel like 10, so 10 would be 20 and unless you're a pro 20 may be overkill.
You can save money and spread it out a little longer with just 5 a day.
dont wory he already feel it,, he say placebo i say its in blod alreasdy doign it thing few more days he walk around and fellas start loking at him like he is preping for copetition only thing is he will grow while preping lol
gh15 approved
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Very clean feeling, no sweating like I've gotten with other products.
I'll hit another 5iu before bed and then it's off to the races.
You just described the feeling i get when i take a shit.
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dont wory he already feel it,, he say placebo i say its in blod alreasdy doign it thing few more days he walk around and fellas start loking at him like he is preping for copetition only thing is he will grow while preping lol
gh15 approved
I've definitely felt fuller all day today, I feel really good overall. Skin seems to be tightening up a bit.
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yes,, in about 7-10 day your delts will grow another dimention to them from teh rear,, and your waist will be tighter and leaner and wil appear to volumize right as in giving the ilusion of being small but not homo small due to the way the skin will be attach to muscle and the more definition that will come,,it will be more pronounced with time but its all ter after 10-20 day with pharm gh,,you will basicaly feel you have no waist and you have too much of everything else aka delts pecs arms ,,there will be minimal water retention and actualy you will get mroe defined and veins more out by the day ,, ths is the big thing with this gh ....it doesnt give the water blurr that other gh give,, it is pharm grade
gh15 approved
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yes,, in about 7-10 day your delts will grow another dimention to them from teh rear,, and your waist will be tighter and leaner and wil appear to volumize right as in giving the ilusion of being small but not homo small due to the way the skin will be attach to muscle and the more definition that will come,,it will be more pronounced with time but its all ter after 10-20 day with pharm gh,,you will basicaly feel you have no waist and you have too much of everything else aka delts pecs arms ,,there will be minimal water retention and actualy you will get mroe defined and veins more out by the day ,, ths is the big thing with this gh ....it doesnt give the water blurr that other gh give,, it is pharm grade
gh15 approved
yes, agreed, you can see changes in physique very quickly with legit gh. people say 6 months or more because they don't use real gh and get underdosed gh.
i do get some water retention on the gh though, can see it in my face
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yes,, in about 7-10 day your delts will grow another dimention to them from teh rear,, and your waist will be tighter and leaner and wil appear to volumize right as in giving the ilusion of being small but not homo small due to the way the skin will be attach to muscle and the more definition that will come,,it will be more pronounced with time but its all ter after 10-20 day with pharm gh,,you will basicaly feel you have no waist and you have too much of everything else aka delts pecs arms ,,there will be minimal water retention and actualy you will get mroe defined and veins more out by the day ,, ths is the big thing with this gh ....it doesnt give the water blurr that other gh give,, it is pharm grade
gh15 approved
Same for thanktropin?
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yes,, in about 7-10 day your delts will grow another dimention to them from teh rear,, and your waist will be tighter and leaner and wil appear to volumize right as in giving the ilusion of being small but not homo small due to the way the skin will be attach to muscle and the more definition that will come,,it will be more pronounced with time but its all ter after 10-20 day with pharm gh,,you will basicaly feel you have no waist and you have too much of everything else aka delts pecs arms ,,there will be minimal water retention and actualy you will get mroe defined and veins more out by the day ,, ths is the big thing with this gh ....it doesnt give the water blurr that other gh give,, it is pharm grade
gh15 approved
YES, WITH NOVO AT 4IU I FELT THIS BY DAY 10. MY ROUNDNESS FROM THE SIDES PICKED UP, I GUESS U R RIGHT HERE....THE REAR DELT ADDED ANOTHER WHOLESOME ASPECT TO MY BODY. FROM THE SIDE YOU LOOK JUST LIKE YOU ADDED ANOTHER PIECE, FROM THE FRONT YOU LOOK LIKE YOUR DRAPED.
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yes, agreed, you can see changes in physique very quickly with legit gh. people say 6 months or more because they don't use real gh and get underdosed gh.
i do get some water retention on the gh though, can see it in my face
UR TAKING RIPS RIGHT? IF SO THATS WHY. A LOT OF PEOPLE REPORT RIPS HAVE MASSIVE WATER RETENTION. GREAT PRODUCT, BUT COMES WITH GREAT SIDES.
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yep bro. they were great, within first week could see significant changes in vascularity, already see my waist going down. feeling fuller too. had more water retention than with other gh but rips were real strong so i figure it was a trade off.
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Let's just say I get a very good deal on bulk orders.
SO UR AFFLIATED?
Used lots of cheap generics that I assume had some insulin in the vial, which mde me go hypo.
With the Kigs, this hasn't happened.
NIPERTROPIN?
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SO UR AFFLIATED?
NIPERTROPIN?
Nah, not affiliated.
And yeah, IP Nipers
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Nah, not affiliated.
And yeah, IP Nipers
LOL WHEN HE SENT OUT THAT WARNING U JUST KNEW RIGHT THERE ITS FUCKING INSULIN.
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LOL WHEN HE SENT OUT THAT WARNING U JUST KNEW RIGHT THERE ITS FUCKING INSULIN.
Yeah, even on slin I've never gone so hypo, haha.
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VERY VERY VERY VR VERY VERY GOOD POSTING!! ,, everything true 100%
gh15 approved
god of hormones...i am a pupil of the great ways....just got on this board...i have to add something here, maybe a question, as a friend of mine is doing a gh experiment daily and the info is conflicting....the "experiment"-he is eating the same foods at same times, and training at same time.....he has about 10 different brand gh on hand...he also has a digital bg meter.......he takes a baseline bg reading and inject 10iu of various brands....takes a reading after 5 min, after 10 min, after 20 min and after 30 min.....he has tested all different brands and the EXACT same thing happens on each, not to the same degree, but the same thing...within 5 min, bg drops bc of the residual insulin left over which is used with the ecoli in the production to make much more gh than without it rite? then from 5-30 minutes an extreme bg RISE, NOT FALL....every time result same, bg RISE, not FALL from 5-30 minute....manyy major brands tested...yes even kigs perform same way....from everything ive read, this is opposite of the info ive gathered stating gh makes bg lower....this experiment is done in real time with pics updated at the minute of readings....what do you think of these results??
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god of hormones...i am a pupil of the great ways....just got on this board...i have to add something here, maybe a question, as a friend of mine is doing a gh experiment daily and the info is conflicting....the "experiment"-he is eating the same foods at same times, and training at same time.....he has about 10 different brand gh on hand...he also has a digital bg meter.......he takes a baseline bg reading and inject 10iu of various brands....takes a reading after 5 min, after 10 min, after 20 min and after 30 min.....he has tested all different brands and the EXACT same thing happens on each, not to the same degree, but the same thing...within 5 min, bg drops bc of the residual insulin left over which is used with the ecoli in the production to make much more gh than without it rite? then from 5-30 minutes an extreme bg RISE, NOT FALL....every time result same, bg RISE, not FALL from 5-30 minute....manyy major brands tested...yes even kigs perform same way....from everything ive read, this is opposite of the info ive gathered stating gh makes bg lower....this experiment is done in real time with pics updated at the minute of readings....what do you think of these results??
I THINK OSIRIS IS FULL OF SHIT. I WOULDNT BELIEVE A THING THAT DUDE POSTS. IS HE WHAT HES DOING RIGHT? MAYBE, BUT DUDE IS ANOTHER BODYBUILDER....LIAR. YOU GOTTA REMEMBER EVERYONE IS AFFLIATED.
COULD BE TRUE THOUGH, I JUST WOULD TAKE SOMEONE ELSES WORD FOR IT.
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Kigs from Kamikazi???
That's a real stupid name Hide chose there to sell steroids. ;D ;D ;D ;D
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god of hormones...i am a pupil of the great ways....just got on this board...i have to add something here, maybe a question, as a friend of mine is doing a gh experiment daily and the info is conflicting....the "experiment"-he is eating the same foods at same times, and training at same time.....he has about 10 different brand gh on hand...he also has a digital bg meter.......he takes a baseline bg reading and inject 10iu of various brands....takes a reading after 5 min, after 10 min, after 20 min and after 30 min.....he has tested all different brands and the EXACT same thing happens on each, not to the same degree, but the same thing...within 5 min, bg drops bc of the residual insulin left over which is used with the ecoli in the production to make much more gh than without it rite? then from 5-30 minutes an extreme bg RISE, NOT FALL....every time result same, bg RISE, not FALL from 5-30 minute....manyy major brands tested...yes even kigs perform same way....from everything ive read, this is opposite of the info ive gathered stating gh makes bg lower....this experiment is done in real time with pics updated at the minute of readings....what do you think of these results??
your friend is osiris from pm???? you don't want to get these guys started on him... LOL should have pm'd your question if he is your "friend"
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god of hormones...i am a pupil of the great ways....just got on this board...i have to add something here, maybe a question, as a friend of mine is doing a gh experiment daily and the info is conflicting....the "experiment"-he is eating the same foods at same times, and training at same time.....he has about 10 different brand gh on hand...he also has a digital bg meter.......he takes a baseline bg reading and inject 10iu of various brands....takes a reading after 5 min, after 10 min, after 20 min and after 30 min.....he has tested all different brands and the EXACT same thing happens on each, not to the same degree, but the same thing...within 5 min, bg drops bc of the residual insulin left over which is used with the ecoli in the production to make much more gh than without it rite? then from 5-30 minutes an extreme bg RISE, NOT FALL....every time result same, bg RISE, not FALL from 5-30 minute....manyy major brands tested...yes even kigs perform same way....from everything ive read, this is opposite of the info ive gathered stating gh makes bg lower....this experiment is done in real time with pics updated at the minute of readings....what do you think of these results??
gh increases blood glucose levels because gh increases insulin resistance to counteract igf-1s effects
anyways, if you run slin without gh and then go on gh while running same dosage slin, you'll notice you won't need as many carbs with the slin to not feel hypo
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your friend is osiris from pm???? you don't want to get these guys started on him... LOL should have pm'd your question if he is your "friend"
well idk....ive talked to him a few times just like ive talked to you before lol...."internet forum guy i think is decent" a better way to phrase it instead of "friend"? i guess im not in the forum scene enough to know who has beef with who lol.... either way, i wasnt having a discussion about someone, rather trying to figure out what the facts are....Btw, good to see u B...they r very stirred up over there about you lol.....
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that someome would have 10 different brands of gh on hand, that someone would then go through the shit of eating the same thing at same time of day, lol, come on dude use your head, who would do this without an agenda? without a buck to make?
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After gh shot how long do you wait for shake?
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After gh shot how long do you wait for shake?
In the AM I shoot 5iu, shower and get dressed and then eat. Usually 20min or so.
PM, I pin 5iu and then have some pineapple juice, a banana and hit the sack.
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that someome would have 10 different brands of gh on hand, that someone would then go through the shit of eating the same thing at same time of day, lol, come on dude use your head, who would do this without an agenda? without a buck to make?
Yeah but after all the testing he bought about 50 kits of Kigs. So that tells u which one is best.
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Day 3
Slept incredibly well last night. This stuff is kicking in FAST
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Here's what I can say as fact regarding the relationship between insulin and HGH. I had to take a test to measure insulin sensitivity when I first "applied" for TRT. After an over night fast they inject you with insulin. It didn't take long before I began to black out and then they immediately inject you with Dextrose. They did this a couple of times. The purpose was to measure your sensitivity to insulin or insulin resistance.
When I looked at the chart/readings the relationship of insulin to HGH it was inversely proportional. As they injected insulin into one vein and as my blood sugar dropped my HGH level rose. After they injected Dextrose into another vein and my blood sugar started to rise my HGH level started to drop. The inverse relationship (as one rises and the other drops) was very direct and predictable.
I guess it would be more accurate to say that it was the relationship between the levels of blood sugar. As blood sugar rose HGH went down and as blood sugar fell HGH went up. I wonder what would happen if they injected insulin and HGH at the exact same time.
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insulin protocols usually involve injecting insulin 30-40 minutes after injecting hgh, there's no just insulin for bodybuilding, it is the insulin and hgh relationship that is beign expoited for anabolic gain, not just insulin
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just out of curiosity how much money worth of drugs is 5iu kigtropin
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just out of curiosity how much money worth of drugs is 5iu kigtropin
5 iu kigtropin from DL is about $11.
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5 iu kigtropin from DL is about $11.
so $330 a month on HGH alone
how much does he spend on other drugs a month?
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so $330 a month on HGH alone
how much does he spend on other drugs a month?
I'm sure you can get a bulk discount if you order, say, 50 kits at once et cetera.
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I'm sure you can get a bulk discount if you order, say, 50 kits at once et cetera.
This...always ask your source if they will work with you in bulk. 99% of the time, I'm told yes.
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insulin protocols usually involve injecting insulin 30-40 minutes after injecting hgh, there's no just insulin for bodybuilding, it is the insulin and hgh relationship that is beign expoited for anabolic gain, not just insulin
I hope to one day understand how insulin works with HGH in taking one to the next level. I know insulin shutters nutrients into the cells. If you have a healthy pancreas then no matter how much you eat you will produce enough insulin to do this. Why having more creates such an anabolic effect greater than just taking HGH alone.
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I hope to one day understand how insulin works with HGH in taking one to the next level. I know insulin shutters nutrients into the cells. If you have a healthy pancreas then no matter how much you eat you will produce enough insulin to do this. Why having more creates such an anabolic effect greater than just taking HGH alone.
IGF-1
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I hope to one day understand how insulin works with HGH in taking one to the next level. I know insulin shutters nutrients into the cells. If you have a healthy pancreas then no matter how much you eat you will produce enough insulin to do this. Why having more creates such an anabolic effect greater than just taking HGH alone.
insulin increases growth hormone receptor sites, without insulin they won't birth
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insulin increases growth hormone receptor sites, without insulin they won't birth
Link? Source? Not doubting you I just want to read up and research more on this subject. I really never heard this before. Not even from Milos.
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Link? Source? Not doubting you I just want to read up and research more on this subject. I really never heard this before. Not even from Milos.
lol@ "not even from Milos".
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5ius of kigs $7
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Link? Source? Not doubting you I just want to read up and research more on this subject. I really never heard this before. Not even from Milos.
i can pm it to you some time later i'll have to look for it and i've just got done reading a bunch after finishing doing high rep deadlift sets so i don't feel like doing shit at the moment
want to add an addendum since while it's obvious, the way i wrote previous post might be confusing and give the wrong impression that hgh won't or can't be anabolic unless you shoot insulin, which is wrong because your body produces it's own insulin all the time. it's just that using a little bit of insulin, like 5iu humalog will increase the effectiveness of the hgh
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lol@ "not even from Milos".
I thought Milos was god of insulina?
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i can pm it to you some time later i'll have to look for it and i've just got done reading a bunch after finishing doing high rep deadlift sets so i don't feel like doing shit at the moment
want to add an addendum since while it's obvious, the way i wrote previous post might be confusing and give the wrong impression that hgh won't or can't be anabolic unless you shoot insulin, which is wrong because your body produces it's own insulin all the time. it's just that using a little bit of insulin, like 5iu humalog will increase the effectiveness of the hgh
No need for PM unless you have personal reasons. Post info here for all to learn from. I've found that most don't seem to know the mechanics of how insulin works in conjunction with HGH.
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There is still a bit of mystique behind why exogenous insulin, especially used in tandem with GH causes such crazy growth. I believe it has to do with IGF-1 as well but I'm not sure by which mechanism/s it works. GH definitely primes your body for growth but something special happens when you introduce insulin.
I guess it'll probably remain a mystery for some time. I follow a lot of endocrinology and metabolism journals and news sites hoping that researchers will publish something to shed some light on it.
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Tomorrow will be one week into Kigs.
Rear delt head is really starting to pop, and my appear tighter daily. Sleep is only getting better, and I could sleep all day if I wanted to, but I'm not tired at all through the day.
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No need for PM unless you have personal reasons. Post info here for all to learn from. I've found that most don't seem to know the mechanics of how insulin works in conjunction with HGH.
(http://i.imgur.com/Mbmvj.jpg)
(http://i.imgur.com/iRf4k.jpg)
this is a growth hormone ligand binding to the growth hormone receptor. note that it has multiple downstream actions, after binding to the GHr, it activates the JAK2, which then initiates the cascade of multiple downsteam actions.
ERK and STAT5B are two pathways of concern for GH induced anabolism, via satellite cell proliferation, and insulin modulates the effects of both. stat5b is the primary pathway in which GH induces growth, it produces IGF-1 at the local cellular level, which i'm sure everyone is aware of how significant igf-1 is for causing growth. with regard to ERK: Independent of it's role in proliferation, ERK activation has clearly been related to c-fos activation that is acutely stimulated by GH (Hodge et al., 1998) and full activation of GH-induced STAT5 signaling may also rely on ERK activation (Pircher et al., 1999) ERK itself causes proliferation, however, there is a probable direct relationship with ERK activation and STAT5B activation. the importance of insulin here is that without insulin ERK will not resensitize, and it requires both the presence of insulin while there is an absence of growth hormone for the pathway to become fully active again.
STAT5B will reactivate while there is a low level of growth hormone, within ~3 hours, however insulin itself will act directly on the STAT5B pathway to induce anabolic effects.
http://www.sciencedirect.com/science/article/pii/S0014579399016890 (http://www.sciencedirect.com/science/article/pii/S0014579399016890)
The STAT multigene family of transcriptional regulators conveys signals from several cytokines and growth factors upon phosphorylation by janus kinases (JAK). Activation of STAT5 is typically mediated by JAK2, but more recent data indicate a direct activation by the insulin receptor kinase. STAT5 exists in two closely homologous isoforms, STAT5a and b. We here describe the selective tyrosine phosphorylation of STAT5b in Kym-1 cells in response to insulin. Blocking insulin signalling by HNMPA-(AM)3, an insulin receptor kinase inhibitor, resulted in the loss of insulin-induced STAT5b tyrosine phosphorylation, whereas the inhibition of JAK2 by the JAK selective inhibitor tyrphostin AG490 had no effect. By contrast, in the same cells, IFNγ-induced STAT5b activation was JAK2-dependent, indicating that this signal pathway is functional in Kym-1 cells. We conclude from this rhabdomyosarcoma model that STAT5b, but not STAT5a is a direct target of the insulin receptor kinase.
furthermore, there is the issue of growth hormone receptor expression, that begins the entire process and cascade of downstream activation of pathways. growth hormone expression, and birth, is a process again modulated by insulin. with marked increases in GHR birth and expression in concordance with increases in insulin dosages, however, after ~10iu of insulin the expression of GHr becomes stymied and dosages above 10iu of insulin become counterproductive.
Insulin Regulation of Human Hepatic Growth Hormone Receptors: Divergent Effects on Biosynthesis and Surface Translocation1
Insulin modulates the biological actions of GH, but little is known about its effect on human hepatic GH receptors (GHRs). Using the human hepatoma cell line HuH7 as a model, we investigated insulin regulation of total, intracellular, and cell surface GHRs and receptor biosynthesis and turnover. Insulin up-regulated total and intracellular GHRs in a concentration-dependent manner. It increased surface GHRs in a biphasic manner, with a peak response at 10 nmol/L, and modulated GH-induced Janus kinase-2 phosphorylation in parallel with expression of surface GHRs. The abundance of GHR messenger ribonucleic acid and protein, as assessed by RT-PCR and Western analysis, respectively, markedly increased with insulin treatment. To examine whether insulin regulates GHRs at the posttranslational level, its effects on receptor surface translocation and internalization were investigated. Insulin suppressed surface translocation in a concentration-dependent manner, whereas internalization was unaffected. Moreover, insulin actions on total GHRs and surface translocation were inhibited by PD98059 and wortmannin, respectively. In conclusion, insulin regulates hepatic GHR biosynthesis and surface translocation in a reciprocal manner, with surface receptor availability the net result of the divergent effects. The divergent actions of insulin appear to be mediated by the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways, respectively.
there is very strong scientific and real world anecdotal evidence showing the synergy between HGH and insulin in inducing greater levels of anabolism. i think the key here to take away is that for optimal results from HGH usage one should incorporate small dosages of insulin, no more than 10iu at a time of novarapid injected IM, along with their hgh.
as an aside, there is a point where too much HGH can become counterproductive as well. at a certain point of over saturation, synthetic growth hormone ligands compete with one another for single growth hormone receptors, causing deactivation of the growth hormone receptor as elucidated by the following picture (second example in the figure):
(http://i.imgur.com/XsCk7.jpg)
so, as a conclusion, the theoretical optimal for HGH usage would be a moderate dosage of HGH, ~10iu or less, used IV (sub-cut before bed though), with usage of a fast acting insulin (novorapid is the fastest) at 7iu IM for faster clearance, two hours before the hgh is administered. obviously, steroids should be used as well but that shouldn't need to be stated.
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someone tell me how to make those pictures larger i'm too lazy and tired to try to figure this out
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what is this all explnatiosn and balonie,, just put in your blood 4 iu kigtropin and wait 30 min and see what happen,,you feel muscle pop within 30 min you are pump 3 dimention hapen within hours,, it is feeling first,, it is tighting feeling of waist,, it is imediate push of the delt from the inside out,, happen in hours! ,, pecs become full and pump,, this all happen within hours of kigtropin inject ,, ONE FUCKING INJECT,,ofcourse you dont look like ron colman on stage ,, but compare to what you were before inject ...thats the diff! you also need to be in good shape when start
the body love legit gh ,, on legit gh you will imediate post inject feel glucose fall slightly you want to drink pine apple,, you dont have to but most do eat sugar preferbly natural sugar,, then within couprl hours even within muntes you feel the emptiness that is called ANABOLIZM ,,
what is emtpiness that is called anabolizm ,, when body become anabolic the stomack empty itself fast ....and ready to take up more food,, this is what happen on legit gh ,, you become a race car....you dont thikn am i on gh ,, you know it! you become superman...you dont wait 3 months you dont wait 3 week ,, it happen on spot,, you feel the waist empty itself and ready to take whatever you give it ,, and in the same time you feel the muscles that count BLOW UP they grow in dimention ,,new surface by the fucking day
this is it friends,, then you load on the aas...to blow it up thick
and no there is no such thing as inject 10 iu for 3 week to see anything,,
fucking 4-5 iu of kigtropina you already feel diff after one damn inject,,why? LEGIT PHARM GRADE GH
gh15 approved
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well, yeah, of course i didn't say not to put hgh into your blood, that was kind of the whole point, that hgh should be used lol
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someone tell me how to make those pictures larger i'm too lazy and tired to try to figure this out
right click on it and then left click "show image"
or
left click on it, hold the click, and drag the pic in your browser website address bar
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right click on it and then left click "show image"
or
left click on it, hold the click, and drag the pic in your browser website address bar
yeah i know that, you doofus, i mean how do i make it show up bigger on the forum? or is that not possible?
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what is this all explnatiosn and balonie,, just put in your blood 4 iu kigtropin and wait 30 min and see what happen,,you feel muscle pop within 30 min you are pump 3 dimention hapen within hours,, it is feeling first,, it is tighting feeling of waist,, it is imediate push of the delt from the inside out,, happen in hours! ,, pecs become full and pump,, this all happen within hours of kigtropin inject ,, ONE FUCKING INJECT,,ofcourse you dont look like ron colman on stage ,, but compare to what you were before inject ...thats the diff! you also need to be in good shape when start
the body love legit gh ,, on legit gh you will imediate post inject feel glucose fall slightly you want to drink pine apple,, you dont have to but most do eat sugar preferbly natural sugar,, then within couprl hours even within muntes you feel the emptiness that is called ANABOLIZM ,,
what is emtpiness that is called anabolizm ,, when body become anabolic the stomack empty itself fast ....and ready to take up more food,, this is what happen on legit gh ,, you become a race car....you dont thikn am i on gh ,, you know it! you become superman...you dont wait 3 months you dont wait 3 week ,, it happen on spot,, you feel the waist empty itself and ready to take whatever you give it ,, and in the same time you feel the muscles that count BLOW UP they grow in dimention ,,new surface by the fucking day
this is it friends,, then you load on the aas...to blow it up thick
and no there is no such thing as inject 10 iu for 3 week to see anything,,
fucking 4-5 iu of kigtropina you already feel diff after one damn inject,,why? LEGIT PHARM GRADE GH
gh15 approved
The emptiness that kigtropin gives is crazy, i inject it, within 30 mins i feel like my stomach is a black hole it feels so empty, no matter how much i ate before
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yeah i know that, you doofus, i mean how do i make it show up bigger on the forum? or is that not possible?
most likely not possible, unless you turn it side ways, message boards often allow only a maximum width but not length
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The emptiness that kigtropin gives is crazy, i inject it, within 30 mins i feel like my stomach is a black hole it feels so empty, no matter how much i ate before
Agreed.
It's definitely a different feeling, if I wanted to I could eat every hour on the hour. But I can also go 3-4 hours without a meal if I'm at work or something and my stomach isnt killing me, I'm just ready to eat.
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Agreed.
It's definitely a different feeling, if I wanted to I could eat every hour on the hour. But I can also go 3-4 hours without a meal if I'm at work or something and my stomach isnt killing me, I'm just ready to eat.
Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.
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Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.
This is a different feeling from GHRP. After a shot of that I was craving carbs. To the point I could stuff my face for an hour and be okay, but this isn't making me NEED anything. I'm just able to take in an utilize anything I eat.
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Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.
bwhaha ha ha ha ha... fuck bro, you inject 4iu's of kami's kigs and you will throw all that peptide bullshit in the fucking trash... now igf-des.. now that is a good peptide if used in a specific manner.. the other peptides, well if you can't afford HGH (wich i find impossible) then use what u gotta use it guess, but don't come to us asking why you can't win your state show...LOL
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Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.
not even close to that garbage peptide,, this is legit pharm grade gh ,, the nails grow in less than 24 hours,, yuo cut them they grow GROWWWW in 24 hours,, not 5 day nto 7 day 24 hours!! grow white like a monky ,, your body renew itself very fast,,
gh15 approved
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i want to try these kigs now solely to see how they compare and also because i want to see if they live up to the hype that they're that much stronger than other china gh
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i want to try these kigs now solely to see how they compare and also because i want to see if they live up to the hype that they're that much stronger than other china gh
Well worth the money
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what is this all explnatiosn and balonie,, just put in your blood 4 iu kigtropin and wait 30 min and see what happen,,you feel muscle pop within 30 min you are pump 3 dimention hapen within hours,, it is feeling first,, it is tighting feeling of waist,, it is imediate push of the delt from the inside out,, happen in hours! ,, pecs become full and pump,, this all happen within hours of kigtropin inject ,, ONE FUCKING INJECT,,ofcourse you dont look like ron colman on stage ,, but compare to what you were before inject ...thats the diff! you also need to be in good shape when start
the body love legit gh ,, on legit gh you will imediate post inject feel glucose fall slightly you want to drink pine apple,, you dont have to but most do eat sugar preferbly natural sugar,, then within couprl hours even within muntes you feel the emptiness that is called ANABOLIZM ,,
what is emtpiness that is called anabolizm ,, when body become anabolic the stomack empty itself fast ....and ready to take up more food,, this is what happen on legit gh ,, you become a race car....you dont thikn am i on gh ,, you know it! you become superman...you dont wait 3 months you dont wait 3 week ,, it happen on spot,, you feel the waist empty itself and ready to take whatever you give it ,, and in the same time you feel the muscles that count BLOW UP they grow in dimention ,,new surface by the fucking day
this is it friends,, then you load on the aas...to blow it up thick
and no there is no such thing as inject 10 iu for 3 week to see anything,,
fucking 4-5 iu of kigtropina you already feel diff after one damn inject,,why? LEGIT PHARM GRADE GH
gh15 approved
Very good, and for those who keep asking about nd blues (I presume I can put thanks also here) they give same exact emptiness feeling, maybe not that extreme like gh15 described above but it does! Personal experience full dinner eaten the other day, then a shot of 5iu nd blues (been on since Sep) and boooom felt like eating juicy 5 guys burger and fries together with some ice cream or chocolate in no time.
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Very good, and for those who keep asking about nd blues (I presume I can put thanks also here) they give same exact emptiness feeling, maybe not that extreme like gh15 described above but it does! Personal experience full dinner eaten the other day, then a shot of 5iu nd blues (been on since Sep) and boooom felt like eating juicy 5 guys burger and fries together with some ice cream or chocolate in no time.
I wonder: what if you don't eat when your body is in this state of anabolism (I think that's what gh15 called it -- to lazy to scroll back) due to HGH? Do you go catabolic and actually start to lose muscle in addition to fat?