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Getbig Main Boards => Gossip & Opinions => Topic started by: DK II on February 11, 2012, 02:47:37 AM
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031317
Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis.
Introduction Top
Obesity is a major risk factor for chronic diseases including diabetes, cardiovascular diseases, and hypertension [1]–[4]. Dyslipidemia, in particular, is a direct risk factor for arteriosclerosis, and for liver cirrhosis, and may be partially due to the dysfunction of lipid metabolism in the liver. Therefore, to prevent or reduce arteriosclerosis and cirrhosis, it is important to ameliorate the dysfunction of hepatic lipid metabolism dysfunction.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear hormone receptor superfamily, which regulate energy homeostasis (glucose and lipid metabolisms), inflammation, proliferation, and differentiation [5]–[9]. In particular, PPARα acts as a master regulator of fatty acid oxidation by controlling the transcription of its target genes [10], [11]. Consistent with this function, PPARα is mainly expressed in tissues with high lipid catabolic capacities, such as the liver, skeletal muscle, and brown adipose tissue [7], [12]. It has been reported that the activation of PPARα enhances fatty acid oxidation in the liver and decreases the levels of circulating and cellular lipids in obese diabetic patients [9], [13]. Therefore, the regulation of PPARα activity is one of the most important means of managing chronic disease related to dysfunction in lipid metabolism in the liver.
During the past decade, numerous studies have shown that endogenous and naturally occurring biological molecules, including fatty acids and fatty acid-derivatives, serve as PPARα agonists [14], [15]. In particular, conjugated linoleic acid (CLA) is well known as a potent PPARα agonist [16] and treatment with CLA actually increases the catabolism of lipids in the liver in rodents [17]. However, the effects of CLA derivatives on PPARα remain unclear.
Recently, we reported that a particular CLA derivative, 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA), is present in fresh tomato fruit, and serves as a PPARα agonist [18]. In mouse primary hepatocytes, 9-oxo-ODA enhanced fatty acid oxidation via PPARα activation and consequently inhibited triglyceride accumulation [18]. Interestingly, we developed that processed products such as tomato juice contain 13-oxo-9,11-octadecadenoic acid (13-oxo-ODA), an isomer of 9-oxo-ODA, which was not present in fresh tomato fruit [19].
In this study, we explored whether 13-oxo-ODA acts as a PPARα agonist in vitro and ameliorates dyslipidemia and hepatic steatosis in vivo. Treatment with 13-oxo-ODA activated PPARα in mouse primary hepatocytes. Furthermore, treatment of obese diabetic KK-Ay mice with 13-oxo-ODA suppressed the increase in plasma and hepatic triglyceride (TG) levels resulting from a high-fat diet (HFD), through PPARα activation in peripheral tissues such as the liver and skeletal muscle. In addition, 13-oxo-ODA treatment decreased the plasma glucose level and increased glucose the tolerance ability in the 13-oxo-ODA-fed mice, as has been shown for other PPARα agonists. These findings indicate that 13-oxo-ODA has a possibility to improve the disorder of lipid and carbohydrate metabolism, via PPARα activation.
Materials and Methods Top
Plant materials and chemicals
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For the pussies who don't want to read: 200ml tomato juice 3x day and you're good to go.
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.
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;D ;D
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so what
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For the pussies who don't want to read: 200ml tomato juice 3x day and you're good to go.
Good find. There's already a medication in the UK called: Ateronon (Tomato Pill Capsules).
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Good find. There's already a medication in the UK called: Ateronon (Tomato Pill Capsules).
Cool. But this product only contains Lycopene, which is good for you, but they now found the 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is funnily enough only present in tomato juice.
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Sorry I didn't read the whole thing but any indication on just how effective it is? Only marginal or significant?
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Cool. But this product only contains Lycopene, which is good for you, but they now found the 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is funnily enough only present in tomato juice.
Nice, i hope they make a concentrated formula out of it, this thing might have endless applications.
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For the pussies who don't want to read: 200ml tomato juice 3x day and you're good to go.
;D
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Bloody Mary anyone?
(http://blogs.sfweekly.com/foodie/BloodyMary.jpg)
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Sorry I didn't read the whole thing but any indication on just how effective it is? Only marginal or significant?
Well so far it is only on mice, but it looks somewhat promising.
I bought the last two bottles of tomato juice today in the store, honestly all fukcing Japan is over it. NO tomato juice available in Tokyo, LOL.
Nice, i hope they make a concentrated formula out of it, this thing might have endless applications.
If the price is good, ok, but 200ml tomato juice cost next to nothign, a fatloss supplement will come at 30-40$$ per 100 capsules.
Also, the tomato juice has a lot of other health benefits as well, the lycopen among them. Stick with the juice and you'll be fine.
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Bloody Mary anyone?
(http://blogs.sfweekly.com/foodie/BloodyMary.jpg)
3 times a day, yes!!!
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Everything in Japan seems to be about meltdowns... be it fat or Nuclear Reactors.
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Everything in Japan seems to be about meltdowns... be it fat or Nuclear Reactors.
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Also, the tomato juice has a lot of other health benefits as well, the lycopen among them. Stick with the juice and you'll be fine.
I know just not a fan of it at all + where i live tomato juice really isn't that cheap.
PS. I'm just a member of the pill generation... ;D
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Can HGH Help Diabetes?
There are some indications that human growth hormone may actually improve diabetes. A study done at John Hopkins about the effects of HGH on blood glucose supports the idea that when elderly people have low human growth hormone they also have more intraabdominal fat and their insulin acts less well.
In this situation they have a tendency to have high blood sugar. If these elderly people are given growth hormone therapy correctly, rather than excessively, their blood sugar levels should improve rather than worsen.
Thierry Hertoghe, MD, who specializes in hormone replacement therapy in Brussels believes that human growth hormone helps to promote the action of insulin. He believes that because HGH helps to direct the insulin to put glucose into the muscular cells, cardiac cells, and nerve cells, rather than the fat cells of the body HGH may actually help to improve diabetes.
Greg Fahy, Ph.D., of the Naval Medical Research Institute has stated that he may have discovered a method to possibly cure adult-onset diabetes using HGH. He has stated that his own experiments have shown that human growth hormone is very beneficial for diabetes.
DISCUSS!
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For the pussies who don't want to read: 200ml tomato juice 3x day and you're good to go.
If you are an obese, diabetic mouse.
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next up, orange has natural multi vitamins and the fresh juice of the fruit makes your overall well being better ::)
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you look fucking great ;D
(http://holdinghopechasinggrace.files.wordpress.com/2010/09/14.jpeg)
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Bloody Mary anyone?
(http://blogs.sfweekly.com/foodie/BloodyMary.jpg)
Love bloody Mary's!! Anyone try the spicy V8's? I like those much more than than the regular V8
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>:(
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For the pussies who don't want to read: 200ml tomato juice 3x day and you're good to go.
haha, you just read my mind
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>:(
:D
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Johnny Falcon has known this for years.
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Tomato juice taste like shit.
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Knew I shoulda bought that Clamato stock.
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Knew I shoulda bought that Clamato stock.
Beefamato > Clamato
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Johnny Falcon has known this for years.
That man is ahead of his time.
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Hello heartburn
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Tomato juice taste like shit.
no, it tastes like tomato.... your mother says my cock tastes like shit after i fuck her in the ass...
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no, it tastes like tomato.... your mother says my cock tastes like shit after i fuck her in the ass...
You're Old Guard around here and all but that is the worst your mom crack I've ever read. You're not applying yourself. Get your mom to sign it and return it to Ron or we'll have to schedule a mom-Ron conference about you.
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Good find. There's already a medication in the UK called: Ateronon (Tomato Pill Capsules).
V8 juice has been around for awhile...
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We grow thousands of lbs a tomatoes a year. No wonder I stay ripped. 8)
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V8 juice has been around for awhile...
And?
You can't even compare that to pharmaceutical grade Lycopene.
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I like tomato juice.
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Lycanthropy > Tomato Juice
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You're Old Guard around here and all but that is the worst your mom crack I've ever read. You're not applying yourself. Get your mom to sign it and return it to Ron or we'll have to schedule a mom-Ron conference about you.
;D
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We grow thousands of lbs a tomatoes a year. No wonder I stay ripped. 8)
Growing tomatoes doesn't help, you have to eat them, dickwit.
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Kai Greene approved
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Kai Greene approved
LOL, holy shit.
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;D ;D
is it just me or is there absolutely no reason for laughter ? Seriously, there is nothing funny said, but lots of laughter.
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is it just me or is there absolutely no reason for laughter ? Seriously, there is nothing funny said, but lots of laughter.
Not just you, that was painful. Dude would still be shaving meat back in the kebab shop if not for the 4 drink minumum.
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Not just you, that was painful. Dude would still be shaving meat back in the kebab shop if not for the 4 drink minumum.
fuckinig arabs.
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Bodybuilders don't drink...they inject.
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fuckinig arabs.
funny
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funny
;D ;D ;D ;D ;D
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fuckinig arabs.
way over the line >:(
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old news, I've been following Falcon principles with optimal results.