Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Main Boards => Gossip & Opinions => Topic started by: Vince G, CSN MFT on December 13, 2012, 09:07:26 AM
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Many in the bodybuilding and nutritional supplement industry had been following the personal injury lawsuit brought against Species Nutrition. Unfortunately, while it ended without a trial, we can safely infer that it didn’t end well for Species Nutrition; a confidential settlement was agreed upon. With that in mind, we can turn our attention from the legal case to the medical case.
The following article (a case study and literature review) was published in the Canadian Journal of Gastroenterology. Although it is well over a year old, it seems to have avoided being picked up by any of the major blogs or websites out there – so with that in mind, I present to you the published case study (edited and abbreviated with a link to the full study at the end) of the young woman who found herself in need of a liver transplant as a result (her Doctor’s conclusion, not mine) of taking Species Nutrition’s Somalyze and Lipolyze:
A previously healthy 28-year-old female bodybuilder with no risk factors for liver disease presented to her local emergency centre with fatigue, malaise, inability to exercise and new-onset jaundice. Her symptoms worsened over a span of one week before hospitalization. Initially, she was confused, and over two days became obtunded and eventually required intubation for airway protection before her transfer to The Mount Sinai Medical Center (New York, USA) for liver transplant evaluation.
The patient was a professional bodybuilder taking a multi-ingredient, nonstimulant health supplement and fat burner (Somalyze and Lipolyze, Species Nutrition, USA). Somalyze contains usnic acid (4 mg), propionyl-L-carnitine (167 mg), phosphatidylcholine/phosphatidylethanolamine (50 mg), gamma-aminobutyric acid (667 mg) and vitamin E (27 IU) per capsule. Lipolyze contains usnic acid (12 mg), propionyl-L-carnitine (500 mg), green tea extract (300 mg), guggulsterone Z and guggulster-one E (10 mg), cyclic adenosine monophosphate (2 mg) and vitamin E (20 IU) per capsul. She was taking one to two capsules of Somalyze at bedtime and one capsule of Lipolyze with meals three times a day as recommended for one month before illness. Her other medications included over-the-counter calcium and fibre supplements, and caffeine tablets.
On evaluation at The Mount Sinai Medical Center, there were no stigmata of chronic liver disease. Blood work revealed a total serum bilirubin level of 82.08 mmol/L (normal range 1.71 mmol/L to 20.5 mmol/L), a direct bilirubin level of 47.88 mmol/L (1.71 mmol/L to 13.6 mmol/L), a serum alanine aminotransferase level of 1220 U/L (1 U/L to 53 U/L), a serum aspartate aminotransferase level of 577 U/L (1 U/L to 50 U/L), an alkaline phosphatase level of 111U/L (30 U/L to 110 U/L), a gamma-glutamyl transferase level of 125 U/L (8 U/L to 35 U/L), an international normalized ratio of 2.6 and a serum creatinine level of 53.04 μmol/L (44.2 μmol/L to 106.2 μmol/L). Her hematological markers, electrolyte levels, metabolic profile, amylase levels and lipase values were unremarkable.
Etiological workup included the following: negative viral serology (hepatitis A virus immunoglobulin M, hepatitis B virus surface antigen and core antibody, hepatitis C virus antibody [polymerase chain reaction assay], cytomegalovirus DNA and Epstein-Barr virus immunoglobulin M); negative syphilis rapid plasma regain; negative autoimmune markers (antinuclear antibody, antiliver kidney muscle antibody, antimitochondrial antibody and antismooth muscle antibody); and normal serum gamma globulins. Extensive toxicology screening was negative, with no features of acetaminophen toxicity (acidosis, high lactate or renal failure). She had normal levels of ferritin, ceruloplasmin and alpha-1 antitrypsin. A pregnancy test was negative. A computed tomography scan of her abdomen revealed a normal size liver with a patent portal vein, hepatic artery, hepatic vein and normal biliary anatomy. Her spleen was normal and no ascites was noted.
The patient’s encephalopathy worsened and she remained unresponsive. A computed tomography scan of her head was normal. An intracranial pressure monitor was placed, which measured an intracranial pressure of 19 mmHg and a cerebral perfusion pressure of 77 mmHg to 82 mmHg. She underwent successful cadaveric orthotopic liver transplantation on hospital day 2. By postoperative day 4, she was awake and alert. She experienced no significant postoperative complications and was discharged home for outpatient follow-up.
Histopathological examination of the liver explant showed massive hepatic necrosis and parenchymal collapse, with a few islands of ductular regeneration.
(http://www.anabolize.com/wp-content/uploads/2012/12/liver1-300x174.jpg)
(http://www.anabolize.com/wp-content/uploads/2012/12/liver2-300x218.jpg)
Based on the temporal relationship between the use of the dietary supplements and onset of liver failure, literature supporting reports of hepatotoxicity associated with dietary supplements and exclusion of other causes, it is fair to assume that the patient developed fulminant hepatic failure due to dietary supplements. In view of the bulk of the literature, of all the ingredients, usnic acid may have been predominantly responsible for the hepatoxicity. Although usnic acid was the main hepatotoxic agent, its effect was possibly perpetuated by other hepatotoxins, including green tea and gum guggul, also contained in the dietary supplements taken by the patient.
Ok, so what I did here was give you the beginning of the case study and the end, because the doctors who wrote it up are a bit long winded, and get into a huge discussion about usnic acid and liver stuff, and it’s not terribly interesting to the narrative. But it’s there in black and white if you want to read the whole thing for yourself:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076034/
In other news, it’s been reported that the owner of Species Nutrition, Dave Palumbo, will be moving to Las Vegas, to share eyeliner with illusionist du jour, Criss Angel, who will attempt to create the illusion of real hair on Dave’s head, instead of the underwatered Chia Pet look that he has going now. Good luck/tidings to Aaron Singerman are in order as well, as he recently announced his takeover of RxMuscle due to Dave’s departure.
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Reading a thread that long by Vince is a sign of mental illness. Be it a copy and paste.
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She probably being on his keto-diet didn't help matters neither.
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A long thread by Vincent G is always about as interesting as a Jay Cutler interview, keep it to 2 lines in future, Chief.
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What is her name?
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What is her name?
Vince goodrum
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Vince goodrum
The article references a female bodybuilder, not bikini chick.
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The article references a female bodybuilder, not bikini chick.
I stand corrected.
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Some people have to have very sensitive livers, either that or they took wayyy more than there were supposed to for a long time. Myself and countless others have tried that product and our liver's are still working great.
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Some people have to have very sensitive livers, either that or they took wayyy more than there were supposed to for a long time. Myself and countless others have tried that product and our liver's are still working great.
That's great logic, you've done tons of barebacking and you haven't caught aids yet.
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How many female Bodybuilders out there are 100% natural and not on a mixture of injectables/orals (that wreak havoc on liver & kidneys)? I know NONE.
This story has holes.
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cliff notes please
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Is Palumbo really moving to Vegas or is that part of the joke?
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Wonder if this girl was using Tylenol at any time during or before her symptoms.
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That's great logic, you've done tons of barebacking and you haven't caught aids yet.
The logic is that there are 100's, probably 1000's of different medications, prescription and not that can cause liver damage. Acetaminophen has destroyed many a liver and is still very widely used. Most people can take large amounts of oral steroids for long periods of time and have no issues. However there are a select 1% or less that for some reason, there liver is extra sensitive and wham, liver damage. Same with alcohol, some severe alcoholics can drink for 20-30 years and there liver never has issues while others who drink less get major problems. Hell there are people now suing 5 hour energy claiming the caffeine caused them to have a heart attack or whatever. Same reason ephedra got banned.
Point being there are many products/drugs that work great for 99.5% of people. However there are some for unknown reasons that have sever issues/sides and those are the ones that sue and screw it up for everyone else.
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there are several relevant parts to melvin's post (no shit)
1- Who is the Canadian professional female bodybuilder in question who needed the kidney transplant following her intensive course of Species products?
2- Clearly polumbo has given erin singerman the keys to the house : erin has moved in all his buddies like louis urinal, Pwee brain etc into positions of 'power' in Rx , got rid of anyone who opposed him, e.g jeff the producer, hipolito mejia. Polumbo is now reduced to doing internet TV shows with his 16 year old fat nephew, his 60 year old obese aunt, and some bespectacled lesbian working at the warehouse as the new 'whack pack' (there is still jimmy d'bull who is a victim in all this due to his lack of options)
(http://i1123.photobucket.com/albums/l542/criscolumbus/newpolumbocrew2.jpg)
(http://i1123.photobucket.com/albums/l542/criscolumbus/newpolumbocrew.jpg)
3- Erin singerman remaining true to his past as heroin drug dealer plans to make Rx into a drugs (any kind: real, fake, imaginary) clearing house. question is: with his priors, how long will he remain a free man?
just like a mexican telenovela
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(http://i1123.photobucket.com/albums/l542/criscolumbus/newpolumbocrew2.jpg)
(http://i1123.photobucket.com/albums/l542/criscolumbus/newpolumbocrew.jpg)
Derek Anthony still has the bloated face. When will he get off the gear!?!?!? Geez.
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;D
good one
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derek anthony at 16
derek anthony at 53 [in a parallel universe (5 synthol shots, 3 tatoos less=survival)]
(http://i1123.photobucket.com/albums/l542/criscolumbus/daba.jpg)
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Poor Dave, getting shafted with a frivolous lawsuit :'(
Didn't anyone tell this female BBer that oral-only cycles are bad for your liver?
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Some people have to have very sensitive livers, either that or they took wayyy more than there were supposed to for a long time. Myself and countless others have tried that product and our liver's are still working great.
Dead by 30.
PIP
Get your liver checked now, if you used one of that kikes potions who knows what illness is on the way.
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Many in the bodybuilding and nutritional supplement industry had been following the personal injury lawsuit brought against Species Nutrition. Unfortunately, while it ended without a trial, we can safely infer that it didn’t end well for Species Nutrition; a confidential settlement was agreed upon. With that in mind, we can turn our attention from the legal case to the medical case.
The following article (a case study and literature review) was published in the Canadian Journal of Gastroenterology. Although it is well over a year old, it seems to have avoided being picked up by any of the major blogs or websites out there – so with that in mind, I present to you the published case study (edited and abbreviated with a link to the full study at the end) of the young woman who found herself in need of a liver transplant as a result (her Doctor’s conclusion, not mine) of taking Species Nutrition’s Somalyze and Lipolyze:
A previously healthy 28-year-old female bodybuilder with no risk factors for liver disease presented to her local emergency centre with fatigue, malaise, inability to exercise and new-onset jaundice. Her symptoms worsened over a span of one week before hospitalization. Initially, she was confused, and over two days became obtunded and eventually required intubation for airway protection before her transfer to The Mount Sinai Medical Center (New York, USA) for liver transplant evaluation.
The patient was a professional bodybuilder taking a multi-ingredient, nonstimulant health supplement and fat burner (Somalyze and Lipolyze, Species Nutrition, USA). Somalyze contains usnic acid (4 mg), propionyl-L-carnitine (167 mg), phosphatidylcholine/phosphatidylethanolamine (50 mg), gamma-aminobutyric acid (667 mg) and vitamin E (27 IU) per capsule. Lipolyze contains usnic acid (12 mg), propionyl-L-carnitine (500 mg), green tea extract (300 mg), guggulsterone Z and guggulster-one E (10 mg), cyclic adenosine monophosphate (2 mg) and vitamin E (20 IU) per capsul. She was taking one to two capsules of Somalyze at bedtime and one capsule of Lipolyze with meals three times a day as recommended for one month before illness. Her other medications included over-the-counter calcium and fibre supplements, and caffeine tablets.
On evaluation at The Mount Sinai Medical Center, there were no stigmata of chronic liver disease. Blood work revealed a total serum bilirubin level of 82.08 mmol/L (normal range 1.71 mmol/L to 20.5 mmol/L), a direct bilirubin level of 47.88 mmol/L (1.71 mmol/L to 13.6 mmol/L), a serum alanine aminotransferase level of 1220 U/L (1 U/L to 53 U/L), a serum aspartate aminotransferase level of 577 U/L (1 U/L to 50 U/L), an alkaline phosphatase level of 111U/L (30 U/L to 110 U/L), a gamma-glutamyl transferase level of 125 U/L (8 U/L to 35 U/L), an international normalized ratio of 2.6 and a serum creatinine level of 53.04 μmol/L (44.2 μmol/L to 106.2 μmol/L). Her hematological markers, electrolyte levels, metabolic profile, amylase levels and lipase values were unremarkable.
Etiological workup included the following: negative viral serology (hepatitis A virus immunoglobulin M, hepatitis B virus surface antigen and core antibody, hepatitis C virus antibody [polymerase chain reaction assay], cytomegalovirus DNA and Epstein-Barr virus immunoglobulin M); negative syphilis rapid plasma regain; negative autoimmune markers (antinuclear antibody, antiliver kidney muscle antibody, antimitochondrial antibody and antismooth muscle antibody); and normal serum gamma globulins. Extensive toxicology screening was negative, with no features of acetaminophen toxicity (acidosis, high lactate or renal failure). She had normal levels of ferritin, ceruloplasmin and alpha-1 antitrypsin. A pregnancy test was negative. A computed tomography scan of her abdomen revealed a normal size liver with a patent portal vein, hepatic artery, hepatic vein and normal biliary anatomy. Her spleen was normal and no ascites was noted.
The patient’s encephalopathy worsened and she remained unresponsive. A computed tomography scan of her head was normal. An intracranial pressure monitor was placed, which measured an intracranial pressure of 19 mmHg and a cerebral perfusion pressure of 77 mmHg to 82 mmHg. She underwent successful cadaveric orthotopic liver transplantation on hospital day 2. By postoperative day 4, she was awake and alert. She experienced no significant postoperative complications and was discharged home for outpatient follow-up.
Histopathological examination of the liver explant showed massive hepatic necrosis and parenchymal collapse, with a few islands of ductular regeneration.
(http://www.anabolize.com/wp-content/uploads/2012/12/liver1-300x174.jpg)
(http://www.anabolize.com/wp-content/uploads/2012/12/liver2-300x218.jpg)
Based on the temporal relationship between the use of the dietary supplements and onset of liver failure, literature supporting reports of hepatotoxicity associated with dietary supplements and exclusion of other causes, it is fair to assume that the patient developed fulminant hepatic failure due to dietary supplements. In view of the bulk of the literature, of all the ingredients, usnic acid may have been predominantly responsible for the hepatoxicity. Although usnic acid was the main hepatotoxic agent, its effect was possibly perpetuated by other hepatotoxins, including green tea and gum guggul, also contained in the dietary supplements taken by the patient.
Ok, so what I did here was give you the beginning of the case study and the end, because the doctors who wrote it up are a bit long winded, and get into a huge discussion about usnic acid and liver stuff, and it’s not terribly interesting to the narrative. But it’s there in black and white if you want to read the whole thing for yourself:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076034/
In other news, it’s been reported that the owner of Species Nutrition, Dave Palumbo, will be moving to Las Vegas, to share eyeliner with illusionist du jour, Criss Angel, who will attempt to create the illusion of real hair on Dave’s head, instead of the underwatered Chia Pet look that he has going now. Good luck/tidings to Aaron Singerman are in order as well, as he recently announced his takeover of RxMuscle due to Dave’s departure.
VERY VERY SCARY STUFF
Not surprising from someone who claims to understand human physiology and disease processes functioning on 2 years of medical school.
It is fair to say Pee Jay Brain is going to end up this route with his liver adenoma and perpetual use of gear.
He started "project small" which was veiled as a chance to "go off" and see how things went, a thinly veiled excuse to stop anabolics to make that adenoma shrink.
Meanwhile despite posting on here and showing Arons bloodwork he refuses to show results from an ultrasound, MR etc etc etc.
The question is :
PJ are you brain enough to stop gear and get better or braun enough to follow Scumbo's advice and end up like the above mentioned BBer?
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female bodybuilders are gross
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female bodybuilders are gross
Yes, they aren't physique artists
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Poor Dave, getting shafted with a frivolous lawsuit :'(
Didn't anyone tell this female BBer that oral-only cycles are bad for your liver?
if i ever have any kidney or liver problems i'm doing the same exact thing, if it's that easy to collect.
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Vince, stop posting this dribble like youre important.
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hahah
i like the "wine" glass
getting "Classy!"
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I wonder if anyone else thats stacked these is shaking? Is the fear legit?
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(http://i1123.photobucket.com/albums/l542/criscolumbus/newpolumbocrew2.jpg)
hahahah this looks like no matter what they're talking about it won't be interesting.A dude in a tapout hat and a fat chick with a beer. respect for the iron bull though.
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VERY VERY SCARY STUFF
Not surprising from someone who claims to understand human physiology and disease processes functioning on 2 years of medical school...
Dave Palumbo never got to the point where he understood the scientific basis of medicine. He is a fraud, selling products with no proven health-effects at all while using busswords to promote them. "Kidney stuff", don't get me started. His "Raw cacao bars" are another scam http://www.davepalumbo.com/STOREV2/rawcacao.html. There are no proven health effects of this product.
NN
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How many female Bodybuilders out there are 100% natural and not on a mixture of injectables/orals (that wreak havoc on liver & kidneys)? I know NONE.
This story has holes.
+1
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Dave Palumbo never got to the point where he understood the scientific basis of medicine. He is a fraud, selling products with no proven health-effects at all while using busswords to promote them. "Kidney stuff", don't get me started. His "Raw cacao bars" are another scam http://www.davepalumbo.com/STOREV2/rawcacao.html. There are no proven health effects of this product.
NN
This.
Dave Palumbo finally contributing something to the medical literature
CJG is not bad or a first paper
Once he kills a few more he should aim for JAMA or NEJM
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.Butterbean in condition, trim an fit. :)
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Species is not a real player in the industry anyway. They don't have much sales
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that is why rx hustle is going to become a drug/scam clearing house under erin
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This.
Dave Palumbo finally contributing something to the medical literature
CJG is not bad or a first paper
Once he kills a few more he should aim for JAMA or NEJM
PNAS, Science and Nature would also be very interested in the scientific production of such a great mind. He should continue his academic career by writing up a thorough case-description of himself and the brand new diagnostic entity that is named after him: Palumboism.
NN
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I never read Vince Basile or Goodrum posts.
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In other news, it’s been reported that the owner of Species Nutrition, Dave Palumbo, will be moving to Las Vegas, to share eyeliner with illusionist du jour, Criss Angel, who will attempt to create the illusion of real hair on Dave’s head, instead of the underwatered Chia Pet look that he has going now.
Yes.
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I never read Vince Basile or Goodrum posts.
very insightful
anything else u care to share? opinions on recent mass shooting perhaps....
are u pro-life (ban guns) or pro-choice (let god choose)?
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Ban guns.
1 bad guy with a gun does more damage than 100000 good guys with a gun
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They're doctors, if you work out and then go on stage to felx your muscles, to them you are a professional bodybuilder.
And where did you get Canada? If you go to the link and look at author information it says "Department of Pathology, Recanati/Miller Transplantation Institute, The Mount Sinai Medical Center, New York, New York, USA"