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Getbig Main Boards => Gossip & Opinions => Topic started by: Slik on October 21, 2018, 12:45:56 PM

Title: MK667 - What’s this MK667 stuff?
Post by: Slik on October 21, 2018, 12:45:56 PM
Junk? Real? Side effects? Waste of $?



(Edit)

Ibutamoren mesylate is a drug that can help increase growth hormone and IGF-1 levels, improve health, muscle and bone strength, metabolism . MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism
Title: Re: What’s this mk667 stuff?
Post by: Coach is Back! on October 21, 2018, 01:09:16 PM
Junk? Real? Side effects? Waste of $?

Haven't tried it. Might be a good alternative to injectable GH. Need to read more up on it.
Title: Re: What’s this mk667 stuff?
Post by: Ted SuperSet on October 21, 2018, 01:22:25 PM
Haven't tried it. Might be a good alternative to injectable GH. Need to read more up on it.

You had a stroke. Better not experiment.
Title: Re: What’s this mk667 stuff?
Post by: Griffith on October 21, 2018, 01:46:25 PM
It signals the pituitary gland to produce more human growth hormone. It can increase HGH levels to about the equivalent of 2 - 4 iu's. Recovery from workouts is greatly improved, it gives a fuller look to muscles, increases weight (mostly water), increases energy, and gives deeper sleep.

Negative side effects are mostly only noticed in the first weeks until the body gets used to it. This includes water retention, increased appetite, lethargy and a bit of a sinusitis type feeling. Deep sleep is one of the positive side effects and this gets a bit less but still remains throughout.

There is also no de-sensitization. Studies in humans have gone continually for 2 years without problems.

However, one thing to watch out for is insulin sensitivity and higher blood sugar levels but this can be largely negated with supplements like alpha lipoic acid together with curcumin.

Also, it is recommended to start with only 5 mg and going up gradually to 20-25 mg's. 10 mg's alone will give roughly the same HGH levels but going over 10 mg's will start increasing IGF-1 levels more.

It would have to be used for several months to truly benefit from it.



Title: Re: What’s this mk667 stuff?
Post by: SF1900 on October 21, 2018, 02:08:12 PM
It signals the pituitary gland to produce more human growth hormone. It can increase HGH levels to about the equivalent of 2 - 4 iu's. Recovery from workouts is greatly improved, it gives a fuller look to muscles, increases weight (mostly water), increases energy, and gives deeper sleep.

Negative side effects are mostly death only noticed in the first weeks until the body gets used to it. This includes water retention, increased appetite, lethargy and a bit of a sinusitis type feeling. Deep sleep is one of the positive side effects and this gets a bit less but still remains throughout.

There is also no de-sensitization. Studies in humans have gone continually for 2 years without problems.

However, one thing to watch out for is insulin sensitivity and higher blood sugar levels but this can be largely negated with supplements like alpha lipoic acid together with curcumin.

Also, it is recommended to start with only 5 mg and going up gradually to 20-25 mg's. 10 mg's alone will give roughly the same HGH levels but going over 10 mg's will start increasing IGF-1 levels more.

It would have to be used for several months to truly benefit from it.






Fixed.
Title: Re: What’s this mk667 stuff?
Post by: Irongrip400 on October 21, 2018, 02:10:59 PM
Is it legal?  If so, it’s junk.
Title: Re: What’s this mk667 stuff?
Post by: SF1900 on October 21, 2018, 02:15:21 PM
You had a stroke. Better not experiment.

 :) :) ;D ;D ;D

(http://i65.tinypic.com/kcdump.png)
Title: Re: What’s this mk667 stuff?
Post by: Coach is Back! on October 21, 2018, 02:57:47 PM
:) :) ;D ;D ;D

(http://i65.tinypic.com/kcdump.png)

Ok, I literally LMAO ;D
Title: Re: What’s this mk667 stuff?
Post by: IronMagazine.com on October 21, 2018, 05:56:50 PM
Junk? Real? Side effects? Waste of $?

it's real and it works, no more need for expensive inject-able HGH.
Title: Re: What’s this mk667 stuff?
Post by: benchmstr on October 21, 2018, 07:57:11 PM
Injectable penis serum

Bench
Title: Re: What’s this mk667 stuff?
Post by: Slik on October 22, 2018, 02:51:53 AM
It signals the pituitary gland to produce more human growth hormone. It can increase HGH levels to about the equivalent of 2 - 4 iu's. Recovery from workouts is greatly improved, it gives a fuller look to muscles, increases weight (mostly water), increases energy, and gives deeper sleep.

Negative side effects are mostly only noticed in the first weeks until the body gets used to it. This includes water retention, increased appetite, lethargy and a bit of a sinusitis type feeling. Deep sleep is one of the positive side effects and this gets a bit less but still remains throughout.

There is also no de-sensitization. Studies in humans have gone continually for 2 years without problems.

However, one thing to watch out for is insulin sensitivity and higher blood sugar levels but this can be largely negated with supplements like alpha lipoic acid together with curcumin.

Also, it is recommended to start with only 5 mg and going up gradually to 20-25 mg's. 10 mg's alone will give roughly the same HGH levels but going over 10 mg's will start increasing IGF-1 levels more.

It would have to be used for several months to truly benefit from it.




Thanks.  Ive had hypoglycemia since a kid so i better not mess with it i guess
Title: Re: What’s this mk667 stuff?
Post by: Powerlift66 on October 22, 2018, 04:18:02 AM
Read many studies and logs on it. It does work, need to find a good company and source though, lots of scammers out there.
Many said they feel like absolute junk on it, but you wont know until you try it.

Ive never tried IronMagazines version, (Muscle Gelz - Humanogen), but it looks promising.
https://www.musclegelz.com/products/humanogen/

The concept does at least, unsure of product validity. (Ingredients, potency, etc).

But Xdermals usually work better than pills. Plus injectable stuff is out here, again, research sites can be sketchy,need to find a known good one so youre not pinning bath-tub brew).
Title: Re: What’s this mk667 stuff?
Post by: ilalin on October 22, 2018, 11:22:41 AM
good stuff, but gotta find the authentic shit
Title: Re: What’s this mk667 stuff?
Post by: oldtimer1 on October 22, 2018, 11:44:20 AM
Does anyone work out anymore without drugs?  Just train for the sake of training?
Title: Re: What’s this mk667 stuff?
Post by: Hypertrophy on October 22, 2018, 11:56:56 AM
Does anyone work out anymore without drugs?  Just train for the sake of training?

I know, right?
Title: Re: What’s this mk667 stuff?
Post by: LurkerNoMore on October 22, 2018, 12:05:35 PM
Bloat Factory In A Bottle
Title: Re: What’s this mk667 stuff?
Post by: Griffith on October 22, 2018, 01:04:38 PM
Does anyone work out anymore without drugs?  Just train for the sake of training?

MK677 helps to recover from injuries, which is why many use it as well.
Title: Re: What’s this mk667 stuff?
Post by: Powerlift66 on October 23, 2018, 01:23:24 AM
Bloat Factory In A Bottle

Thats what most say who log it...
Title: Re: What’s this mk667 stuff?
Post by: spiro on October 23, 2018, 04:13:16 AM
If you want to gain 10 pounds of shit water weight in your face and stomach and be sleepy all day go for it.  I couldn't even make it a week. It has to do a number on blood pressure, blood sugar etc.
Title: Re: What’s this mk667 stuff?
Post by: Griffith on October 23, 2018, 05:49:56 AM
If you want to gain 10 pounds of shit water weight in your face and stomach and be sleepy all day go for it.  I couldn't even make it a week. It has to do a number on blood pressure, blood sugar etc.

Takes about 2 weeks to get used to it, the water retention gets less. It should be taken in the evening, this avoids any sleepiness in the day.
Title: Re: What’s this mk667 stuff?
Post by: Van_Bilderass on October 23, 2018, 07:41:33 AM
Very potent stuff. Absolutely massive water rention, insane appetite. Doesn't always help sleep, may worsen it. In that case maybe take it in the morning. May cause heart rate increase.

It's very effective if you want to eat alot and want pure size. The water is hard to deal with - I put on 16lbs in a week! But I blasted through some strength plateaus that no amount of roids helped me with.
Title: Re: What’s this mk667 stuff?
Post by: Coach is Back! on October 23, 2018, 09:17:38 AM
Control your diet and you'll control the water retention (as with anything). From what I've read this is by no means a replacement for actual GH.
Title: Re: What’s this mk667 stuff?
Post by: Van_Bilderass on October 23, 2018, 10:06:36 AM
Control your diet and you'll control the water retention (as with anything). From what I've read this is by no means a replacement for actual GH.

Can't control this water retention with diet IME. Perhaps lessen it a bit but there's bound to be plenty of water. I started it again and after two 25mg caps I gained about 6lbs already and I can feel the water sloshing in my feet. Can't be too healthy.

It's not a replacement for GH but many claim your IGF-1 can hit levels that take 6-8 or even 10iu of GH if stacked with a GHRH. That should at least assist bodybuilding in different ways.

I'm thinking of doing a much lower dose instead, like 5 or a max of 10mg to lessen the sides, perhaps stacked with some "natural" supps that might boost the gh release a little bit - like Huperzine, melatonin etc.
Title: Re: What’s this mk667 stuff?
Post by: Montague on October 23, 2018, 11:14:03 AM
Can't control this water retention with diet IME. Perhaps lessen it a bit but there's bound to be plenty of water. I started it again and after two 25mg caps I gained about 6lbs already and I can feel the water sloshing in my feet. Can't be too healthy.

It's not a replacement for GH but many claim your IGF-1 can hit levels that take 6-8 or even 10iu of GH if stacked with a GHRH. That should at least assist bodybuilding in different ways.

I'm thinking of doing a much lower dose instead, like 5 or a max of 10mg to lessen the sides, perhaps stacked with some "natural" supps that might boost the gh release a little bit - like Huperzine, melatonin etc.


I didn't realize Huperzine had an effect on hGH secretion.
I'm not doubting your claim; I'm simply curious...
Do you know the mechanism responsible for this?
Title: Re: What’s this mk667 stuff?
Post by: Van_Bilderass on October 23, 2018, 07:08:44 PM

I didn't realize Huperzine had an effect on hGH secretion.
I'm not doubting your claim; I'm simply curious...
Do you know the mechanism responsible for this?

Suppression of somatostatin. Supposedly boosted by EGCG from green tea. I don't know how effective it would or could be IRL, but, for example this PED expert by the name of Brian Batcheldor said to use 200mcg Huperzine, 400 EGCG with arginine along with MK677 in the morning. Then 2iu of GH at night. The supps could theoretically allow you to use a little gh without the gh suppressing the gh release from the MK. The MK at high doses has too many sides at higher doses for long term use so I was thinking a much smaller dose along with other supps would be more tolerable and healthy while still giving a little pro-anabolic effect.

I read about research on MK done on elderly people at a University in my town. It worked wonderfully for increasing IGF but the researchers thought this would never reach the stage where it was released as an Rx drug - because the appetite boost is just too much. Few people want that.

Title: Re: What’s this mk667 stuff?
Post by: Diesel618 on October 23, 2018, 07:52:35 PM
Easy way to double your igf1 levels
Title: Re: What’s this mk667 stuff?
Post by: tres_taco_combo on October 23, 2018, 08:19:53 PM
how is it for anti aging? i plan to use GH for anti aging reasons not for gains.  

gaining weight/size is easy for me so not interested in a water looked
Title: Re: What’s this mk667 stuff?
Post by: tres_taco_combo on October 23, 2018, 10:26:35 PM
dave P on the topic

Title: Re: What’s this mk667 stuff?
Post by: Griffith on October 23, 2018, 11:03:02 PM
how is it for anti aging? i plan to use GH for anti aging reasons not for gains.  

gaining weight/size is easy for me so not interested in a water looked

Works well for anti-ageing, definitely gives a better complexion and can thicken hair too.

For anti-ageing, 10 mg is recommended. 20-25 mg for muscle building, but that will have a lot more water retention and weight gain.



Title: Re: What’s this mk667 stuff?
Post by: Van_Bilderass on October 23, 2018, 11:04:51 PM
how is it for anti aging? i plan to use GH for anti aging reasons not for gains.  

gaining weight/size is easy for me so not interested in a water looked

There is some concern with ghrelin and neural effects - it affects stress and fear response. So a ghrelin mimetic like MK might not be good in the long term, no one knows what kind of negative effects there might be. Perhaps alternate it with peptide gh releasers. A few weeks of each maybe? Though I think MK was studied for 2 or 3 years in some trial and I can't recall any serious sides mentioned.
Title: Re: MK667 - What’s this MK667 stuff?
Post by: willl on November 05, 2018, 03:08:28 PM
there is something about these exo-endogenous hyper-activators that halts my curiosity towards it

if there is a choice, i would prefer an exo shutting down / giving a break to part of my hormonal system while reaping it's beneftis over an exo excessively stimulating / burning through my own system

speeding up my own hormonal cellular metabolic activity from within it's core strangely makes me feel even worse than when I bypass it with an exo


Title: Re: MK667 - What’s this MK667 stuff?
Post by: tres_taco_combo on November 05, 2018, 07:58:35 PM
there is something about these exo-endogenous hyper-activators that halts my curiosity towards it

if there is a choice, i would prefer an exo shutting down / giving a break to part of my hormonal system while reaping it's beneftis over an exo excessively stimulating / burning through my own system

speeding up my own hormonal cellular metabolic activity from within it's core strangely makes me feel even worse than when I bypass it with an exo




way over my head
Title: Re: MK667 - What’s this MK667 stuff?
Post by: falco on November 07, 2018, 09:01:14 AM
there is something about these exo-endogenous hyper-activators that halts my curiosity towards it

if there is a choice, i would prefer an exo shutting down / giving a break to part of my hormonal system while reaping it's beneftis over an exo excessively stimulating / burning through my own system

speeding up my own hormonal cellular metabolic activity from within it's core strangely makes me feel even worse than when I bypass it with an exo




I agree with your view. Long term use may cause shutdown by wear, of the glands who produce them. Like early aging.
Title: Re: MK667 - What’s this MK667 stuff?
Post by: Montague on November 08, 2018, 02:26:06 AM
Natural shutdown will happen with age regardless of use.

Cadaver studies have shown that elderly men (sorry, I can't remember the exact age) have an abundance of hGH in their pituitary gland. The naturally occurring age-related decline in circulating GH levels is due not to a hormone manufacturing problem, but a releasing one.
Title: Re: MK667 - What’s this MK667 stuff?
Post by: falco on November 08, 2018, 03:42:58 AM
Natural shutdown will happen with age regardless of use.

Cadaver studies have shown that elderly men (sorry, I can't remember the exact age) have an abundance of hGH in their pituitary gland. The naturally occurring age-related decline in circulating GH levels is due not to a hormone manufacturing problem, but a releasing one.

Those are great news.
Title: Re: MK667 - What’s this MK667 stuff?
Post by: willl on November 08, 2018, 07:34:44 AM
Natural shutdown will happen with age regardless of use.

Cadaver studies have shown that elderly men (sorry, I can't remember the exact age) have an abundance of hGH in their pituitary gland. The naturally occurring age-related decline in circulating GH levels is due not to a hormone manufacturing problem, but a releasing one.

first statement: one dimensional view (missing the big picture)

second: state source

at the moment, there is too little known about these ghrh secretagogues and it's positives/negatives

right now, all you have are so-called "fountain of youth" formulas that address the superficial well-being factors but worsen the internals

there is not yet a way to maintain/repair internal cellular regeneration

telomere-related or micro-bacterial studies/advances are two of the main leads but probably it's not for this time yet

to summarise: in a subject that wishes to promote his daily T-levels for a prolonged period of time (upper or slightly above physiologic range), there is a big difference in whether he would use pregnyl injections or test replacement. If you can understand the difference and it's implications, there you go
Title: Re: MK667 - What’s this MK667 stuff?
Post by: falco on November 08, 2018, 07:49:56 AM
Some published studies:

https://www.ncbi.nlm.nih.gov/pubmed/28400207

https://academic.oup.com/jcem/article/94/4/1198/2596275

Title: Re: MK667 - What’s this MK667 stuff?
Post by: willl on November 08, 2018, 09:30:45 AM
all these studies are sponsored by pharmaceutical companies, trying to make a buck or a billion by marketing/selling things that have no real (read long) benefit

i'm already too old for this shit, but bodybuilding to me isn't merely about adding inches of muscle mass, it's more about body-building

if anything, adding muscle cells should merely constitute a byproduct