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Getbig Main Boards => Gossip & Opinions => Topic started by: OneMoreRep on January 30, 2022, 07:37:57 AM
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Moderna has launched early-stage clinical trials of an HIV mRNA vaccine. The new vaccine uses mRNA, or messenger RNA, which teaches the body's cells how to make proteins that trigger immune responses.
https://abcnews.go.com/Health/moderna-launches-clinical-trial-hiv-vaccine-mrna-technology/story?id=82510807 (https://abcnews.go.com/Health/moderna-launches-clinical-trial-hiv-vaccine-mrna-technology/story?id=82510807)
Phase I of the trial will enroll 56 healthy, HIV-negative adult participants. Of the volunteers, 48 will receive one or two doses of the mRNA vaccine, and 32 also will receive the booster. The remaining eight will receive just the booster. The first participants in the Phase I trial were given doses at George Washington University School of Medicine and Health Sciences in Washington, D.C., according to a company statement. Researchers have developed not only a primary vaccine but also a booster to deliver HIV immunogens -- molecules that elicit an immune response -- via mRNA. The hope is this process can induce specific white blood cells, called B cells, which can then turn into what are known as broadly neutralizing antibodies that can neutralize the virus.
What say you all?
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so they want to give an HIV vaccine to people who dont have HIV to see if it works??????
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Moderna has launched early-stage clinical trials of an HIV mRNA vaccine. The new vaccine uses mRNA, or messenger RNA, which teaches the body's cells how to make proteins that trigger immune responses.
https://abcnews.go.com/Health/moderna-launches-clinical-trial-hiv-vaccine-mrna-technology/story?id=82510807 (https://abcnews.go.com/Health/moderna-launches-clinical-trial-hiv-vaccine-mrna-technology/story?id=82510807)
Phase I of the trial will enroll 56 healthy, HIV-negative adult participants. Of the volunteers, 48 will receive one or two doses of the mRNA vaccine, and 32 also will receive the booster. The remaining eight will receive just the booster. The first participants in the Phase I trial were given doses at George Washington University School of Medicine and Health Sciences in Washington, D.C., according to a company statement. Researchers have developed not only a primary vaccine but also a booster to deliver HIV immunogens -- molecules that elicit an immune response -- via mRNA. The hope is this process can induce specific white blood cells, called B cells, which can then turn into what are known as broadly neutralizing antibodies that can neutralize the virus.
What say you all?
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Why would you be opposed to this? It seems like a step in the right direction.
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so they want to give an HIV vaccine to people who dont have HIV to see if it works??????
From the link I provided, I came to the same conclusion. It essentially appears as if they want to take healthy HIV negative volunteers, introduce this vaccine into their bodies and the only feasible way to test efficacy from just deductive reasoning would suggest injecting these folks with the HIV virus to then determine if that vaccine works.
Again, I could be wrong, but from what that link suggests, even if not giving us all the minute details, it certainly seems that that would be the thought process behind testing whether it works or not.
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Why would you be opposed to this? It seems like a step in the right direction.
I'm not for or opposed to this. I'm pretty agnostic regarding it for now.
I am simply presenting the information and wanted to gather your thoughts on what you all think regarding this new development from Moderna.
In the past, I have made mention on this forum that mRNA technology will VERY likely be used to develop cures for many types of cancers and viruses like that of HIV. This is early, but certainly in the works. I will find the picture (below) I once posted showing how this was already in the works.
(https://cdn.sanity.io/images/0vv8moc6/pharmacytimes/3196b16964ed72b8ca2ebbc3789464932d03f8a0-882x1326.png)
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From the link I provided, I came to the same conclusion. It essentially appears as if they want to take healthy HIV negative volunteers, introduce this vaccine into their bodies and the only feasible way to test efficacy from just deductive reasoning would suggest injecting these folks with the HIV virus to then determine if that vaccine works.
Again, I could be wrong, but from what that link suggests, even if not giving us all the minute details, it certainly seems that that would be the thought process behind testing whether it works or not.
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https://investors.modernatx.com/news/news-details/2022/IAVI-and-Moderna-Launch-Trial-of-HIV-Vaccine-Antigens-Delivered-Through-mRNA-Technology/default.aspx (https://investors.modernatx.com/news/news-details/2022/IAVI-and-Moderna-Launch-Trial-of-HIV-Vaccine-Antigens-Delivered-Through-mRNA-Technology/default.aspx)
Looks like it is a "phase 1" trial. They will evaluate for safety (I'm assuming monitoring organs etc with bloodwork) and look for a B cell response. I don't think they are injecting them with the HIV virus to see if it works as part of this trial.
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Just avoid being a buttslut manhoe or a swinger. WTF is the problem with people? Oh yeah. They behave like wabid wabbits. FTN.
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https://investors.modernatx.com/news/news-details/2022/IAVI-and-Moderna-Launch-Trial-of-HIV-Vaccine-Antigens-Delivered-Through-mRNA-Technology/default.aspx (https://investors.modernatx.com/news/news-details/2022/IAVI-and-Moderna-Launch-Trial-of-HIV-Vaccine-Antigens-Delivered-Through-mRNA-Technology/default.aspx)
Looks like it is a "phase 1" trial. They will evaluate for safety (I'm assuming monitoring organs etc with bloodwork) and look for a B cell response. I don't think they are injecting them with the HIV virus to see if it works as part of this trial.
By way of phase 1 they will certainly stick to monitoring for safety and the ability for patients to tolerate the vaccine, but by phase 3 that's where you have to test if it actually works, no? And by test, I mean inject these people with an actual HIV virus to determine the efficacy of said HIV mRNA vaccine. Imagine signing up for that.
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Haven't read it but I'm pretty certain no one will be getting injected with HIV, lol. Once they're happy with the safety of it, I'd imagine they will take from a selection of people who currently don't have HIV but are in an at-risk group, e.g. couples with one HIV-positive partner, promiscuous bummers like Matt Canning and Primemuscle; fat, gay Black men like Goodrum, etc.
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Just avoid being a buttslut manhoe or a swinger. WTF is the problem with people? Oh yeah. They behave like wabid wabbits. FTN.
.....or iv drug user/abuser
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.....or iv drug user/abuser
Agreed, sir.
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so they want to give an HIV vaccine to people who dont have HIV to see if it works??????
You get safe and effective sexual access to dime-piece trannies. FOH! I knew this was coming. They are leveling up on PreP.
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What say you all?
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Mandate it under EUA. You can't be too safe.
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Why would anyone trust any Moderna vaccine in the first place?
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HIV = GRIDS
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Why would anyone trust any Moderna vaccine in the first place?
Exactly - Prior to them getting the Formula for The China virus vaccine from China ::)
They were on the Verge of Going broke out of Business .
They had Never had any success in bring a vaccine out & being approved All previous
had failed the Trials.
Of course with the China Virus Vaccine they didn't have to undergone rigorous Clinical trials
Nope The Willing Thick Sheep Lined up to be the Trial Participants ::) FFS Dumb Fuckers.
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Haven't read it but I'm pretty certain no one will be getting injected with HIV, lol. Once they're happy with the safety of it, I'd imagine they will take from a selection of people who currently don't have HIV but are in an at-risk group, e.g. couples with one HIV-positive partner, promiscuous bummers like Matt Canning and Primemuscle; fat, gay Black men like Goodrum, etc.
I was thinking that too, but without actually injecting them with HIV how do they determine if it works, if the folks never get the virus? It’s not like it’s a sure thing you get it from needles and anal sex, right?
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so they want to give an HIV vaccine to people who dont have HIV to see if it works??????
Trust the science. Just like for Covid.
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From the link I provided, I came to the same conclusion. It essentially appears as if they want to take healthy HIV negative volunteers, introduce this vaccine into their bodies and the only feasible way to test efficacy from just deductive reasoning would suggest injecting these folks with the HIV virus to then determine if that vaccine works.
Again, I could be wrong, but from what that link suggests, even if not giving us all the minute details, it certainly seems that that would be the thought process behind testing whether it works or not.
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Um, no. That’s not exactly how trials work.
Still this is fascinating and represents the culmination of years of work leading up to this. I remain hopeful.
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Um, no. That’s not exactly how trials work.
Still this is fascinating and represents the culmination of years of work leading up to this. I remain hopeful.
Hey Bay,
Out of curiosity, how else would they test the actual efficacy of the HIV vaccines?
Are you thinking that they would then inject HIV positive patients with the vaccine to see if the mRNA technology could eradicate/clear HIV infection? Based on that, consider providing the rest of the healthy population with HIV vaccines (much like the HPV vaccine in kids and young adults) for preventive measures?
My thought process behind them actually infecting test subjects with the virus stems from precedents that have shown similar done before (i.e. Human challenge trials which occurred over the last year with COVID vaccine trials):
To aid vaccine research, U.K. approves deliberate infections of volunteers with coronavirus: https://www.science.org/content/article/aid-vaccine-research-uk-approves-deliberate-infections-volunteers-coronavirus (https://www.science.org/content/article/aid-vaccine-research-uk-approves-deliberate-infections-volunteers-coronavirus)
Covid-19: World's first human challenge trials to start in UK: https://www.bbc.com/news/health-56097088 (https://www.bbc.com/news/health-56097088)
Granted, we don't have the necessary urgency that we had with COVID in trying to find an immediate vaccine, but it's not outside of the realm of possibility, as they have clearly done this (recently) before.
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Any given population will have a certain infection rate of HIV per given time period. They match a control group that receives a placebo with an experimental group that receives the vaccine and compare the infection rates after some time. If the vaccine group has a statistically significantly lower rate of HIV at the end of the trial, it indicates that the vaccine confers protection.
It's the exact same way they tested efficacy of the COVID vaccines. "Challenge" trials, wherein participants are intentionally exposed to a pathogen haven't been done in the west in a long time*
*there is or was a recent trial ongoing in the UK in which participants were exposed to Covid19. havent been following it but it was a notable exception
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A hep and hiv vaccine would be great news for anyone wanting to blast tranny's assholes "au naturelle".
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Why would you be opposed to this? It seems like a step in the right direction.
no, that's not what it says, it says they will give the drug containing the mRNA to the volunteers. this will allow them to then look and see if it does what they think it will do in making the body generate the specific b cells or not and in what quantities. then they would move onto trials of infected and not infected people to see if it attacks the HIV virus or not
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From the link I provided, I came to the same conclusion. It essentially appears as if they want to take healthy HIV negative volunteers, introduce this vaccine into their bodies and the only feasible way to test efficacy from just deductive reasoning would suggest injecting these folks with the HIV virus to then determine if that vaccine works.
Again, I could be wrong, but from what that link suggests, even if not giving us all the minute details, it certainly seems that that would be the thought process behind testing whether it works or not.
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no, they will then be able to measure the change in the b-cells within the body to see if the mRNA message triggers the production, how much it produces and if it works. they could then take that blood and test it further; no where in that article does it say they are infecting people with HIV, that woudl be unethical and highly dangerous
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To aid vaccine research, U.K. approves deliberate infections of volunteers with coronavirus: https://www.science.org/content/article/aid-vaccine-research-uk-approves-deliberate-infections-volunteers-coronavirus (https://www.science.org/content/article/aid-vaccine-research-uk-approves-deliberate-infections-volunteers-coronavirus)
Covid-19: World's first human challenge trials to start in UK: https://www.bbc.com/news/health-56097088 (https://www.bbc.com/news/health-56097088)
Granted, we don't have the necessary urgency that we had with COVID in trying to find an immediate vaccine, but it's not outside of the realm of possibility, as they have clearly done this (recently) before.
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These current experimental compounds (THEY ARE NOT VACCINES) are the FIRST to skip rabbit and rat trails and go straight to human children (they are the most resistant and resilient). If anyone received a live HIV infection clinically, it was Tuskeegee 2.0. Tenofovir or in combination with a cocktail appears to work fine. There is absolutely no reason to circumvent animal testing. You'd have to be out of your mind to voluntarily get infected. HIV- is not HIV-free, it's undetectable viroids per ML of blood.
PreP is all over 99% effective at stopping infections. That's why fools are here going raw on ladyboys (No Homo)
Pandora's Box has been open.
Basically, all experimental compounds can literally go to the human subjects now and weed out the side effects. Humans absorb the injuries and high mortality vs. animals.
Like I said, kids are first.
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By way of phase 1 they will certainly stick to monitoring for safety and the ability for patients to tolerate the vaccine, but by phase 3 that's where you have to test if it actually works, no? And by test, I mean inject these people with an actual HIV virus to determine the efficacy of said HIV mRNA vaccine. Imagine signing up for that.
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I don't think they would do that in the US. One might to look into how they proved efficacy of other vaccinations that have come out in the past few decades (HPV?). Without having done so myself I'd speculate that they would take 2 groups of people in some high prevalence area, sub-Saharan Africa comes to mind, do a double blinded vaccination scheme and then measure effects over a long period of time.
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These current experimental compounds (THEY ARE NOT VACCINES) are the FIRST to skip rabbit and rat trails and go straight to human children (they are the most resistant and resilient). If anyone received a live HIV infection clinically, it was Tuskeegee 2.0. Tenofovir or in combination with a cocktail appears to work fine. There is absolutely no reason to circumvent animal testing. You'd have to be out of your mind to voluntarily get infected. HIV- is not HIV-free, it's undetectable viroids per ML of blood.
PreP is all over 99% effective at stopping infections. That's why fools are here going raw on ladyboys (No Homo)
Pandora's Box has been open.
Basically, all experimental compounds can literally go to the human subjects now and weed out the side effects. Humans absorb the injuries and high mortality vs. animals.
Like I said, kids are first.
The animal test phase occurs before it goes to Stage 1 clinical trials...so that's already done, now its being tested on a small group of adults, not children. Tenofvir doesn't treat HIV, it allows patients to live with it and reduces the risk of it developing into AIDS, and the world is a big place and not everyone has access to a drug that they can take for the rest of their lives, or can afford to do it either
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The animal test phase occurs before it goes to Stage 1 clinical trials...so that's already done, now its being tested on a small group of adults, not children. Tenofvir doesn't treat HIV, it allows patients to live with it and reduces the risk of it developing into AIDS, and the world is a big place and not everyone has access to a drug that they can take for the rest of their lives, or can afford to do it either
Where did I say Tenofvir or the other four known drugs are treatments?
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You get safe and effective sexual access to dime-piece trannies. FOH! I knew this was coming. They are leveling up on PreP.
LOL yep.