Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Main Boards => Gossip & Opinions => Topic started by: Lartinos on August 05, 2025, 12:40:38 PM
-
“ How HMGB1 Protein Controls Cellular Aging
HMGB1 normally resides inside the nucleus of cells, where it helps organize DNA. But when cells become stressed or aged, a state scientists call “senescent,” they release this protein into their surroundings. Once outside the cell, HMGB1 can exist in different chemical forms depending on how much oxygen it has been exposed to.
The research team from Korea University College of Medicine discovered that only the “reduced” form of HMGB1 acts as an aging accelerator. Much like how rust depends on environmental conditions, the chemical surroundings determine whether this protein triggers damage. The reduced form, which hasn’t been exposed to much oxygen, can bind to cellular receptors and activate aging pathways. The oxidized form, by contrast, loses this ability.”
https://studyfinds.org/aging-contagious-protein/
-
I think that having a place in nature is right up there for those who can afford a plot of land out away from everyone do it. That's my goal by 50 at the latest.
-
I think that having a place in nature is right up there for those who can afford a plot of land out away from everyone do it. That's my goal by 50 at the latest.
I want to move to the Highlands of Scotland, wifes not so sure.
She said what if you break your leg out hiking and theres no one to rescue you?
I just said I will die, who gives a fuck
-
“ How HMGB1 Protein Controls Cellular Aging
HMGB1 normally resides inside the nucleus of cells, where it helps organize DNA. But when cells become stressed or aged, a state scientists call “senescent,” they release this protein into their surroundings. Once outside the cell, HMGB1 can exist in different chemical forms depending on how much oxygen it has been exposed to.
The research team from Korea University College of Medicine discovered that only the “reduced” form of HMGB1 acts as an aging accelerator. Much like how rust depends on environmental conditions, the chemical surroundings determine whether this protein triggers damage. The reduced form, which hasn’t been exposed to much oxygen, can bind to cellular receptors and activate aging pathways. The oxidized form, by contrast, loses this ability.”
https://studyfinds.org/aging-contagious-protein/
So what does this mean?
-
I want to move to the Highlands of Scotland, wifes not so sure.
She said what if you break your leg out hiking and theres no one to rescue you?
I just said I will die, who gives a fuck
Tell her to become a trained EMT before you move.
-
I want to move to the Highlands of Scotland, wifes not so sure.
She said what if you break your leg out hiking and theres no one to rescue you?
I just said I will die, who gives a fuck
Great spot.
-
Great spot.
struggle to buy a terraced house near me for that price
https://www.rightmove.co.uk/properties/160185308#/?channel=RES_BUY
(https://media.rightmove.co.uk/239k/238916/160185308/238916_PRA10314_IMG_06_0000.jpeg)
(https://media.rightmove.co.uk/239k/238916/160185308/238916_PRA10314_IMG_00_0000.jpeg)
-
I've had an off-grid cabin about 3 hours from my house for a while now. Spending every other weekend there clearly resets my body and mind completely.
If I don't go for a month or two, I can physically and mentally feel negativity.
-
I damn near live in the woods - but wouldn’t change it. Wife feeds rabbits / squirrels / coons / deer whatever is hungry right in the back yard.
-
struggle to buy a terraced house near me for that price
https://www.rightmove.co.uk/properties/160185308#/?channel=RES_BUY
(https://media.rightmove.co.uk/239k/238916/160185308/238916_PRA10314_IMG_06_0000.jpeg)
(https://media.rightmove.co.uk/239k/238916/160185308/238916_PRA10314_IMG_00_0000.jpeg)
Looks like a dream location. It must get windy though, I hope it has good insulation. Bathroom looks nasty.
155k is way too much imo, it's probably a punt and worth asking the agent how much wiggle room there is.
-
Also I see electric radiators in the rooms. The cold up there will be brutal and heating won't be cheap
-
Meanwhile in one of the worst suburbs of Australia:
https://www.realestate.com.au/news/sydney-auctions-dated-fibro-house-in-mt-druitt-sells-for-nearly-2m-after-frenzied-bidding/