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Getbig Main Boards => Gossip & Opinions => Topic started by: beakdoctor on November 29, 2025, 04:28:55 PM
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So many new GH peptides hard to keep up with what does what, especially with the craze on all the fat loss peptides.
I used a GH secretagogue about 7 or 8 years ago and it quickly healed 2 old nagging injuries. Also caused me to eat like a fucking pig, retain water and BP was sky high.
The one currently getting the most talk seems to be semorelin (sp?)
Any knowledgeable getbiggers have an opinion on what's best for muscle growth for the 50 year old + bodybuilder/weight lifter? Which one is best for injury/repair? (Aside from BPC and TB, which are already well known and documented)
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https://www.getbig.com/boards/index.php?topic=700609.0
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https://www.getbig.com/boards/index.php?topic=700609.0
Have not clicked on link.
I'm going to say its a link to Hankins delusional plot to start selling peptides.
I will now click on link.
Survey says?
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If you don't trust the link, just find it stickied on the nutrition board.
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Have not clicked on link.
I'm going to say its a link to Hankins delusional plot to start selling peptides.
I will now click on link.
Survey says?
Thanks for the link.
Great thread. Good information. Dealing with a tricep injury right now. Thought it was torn but after MRI, Ortho doesn't seem to think its a tear. Not really sure what the deal is. Could be a tear that was missed by ortho, could be some kind of nerve damage. FWIW I suffered no bruising and very little pain. In fact it took quite a while for me to even realize the muscle was damaged. It seems to be slightly improving but it has been months. The more rest I give it, the more it seems to heal. But so little 'improvement' it could just be wishful thinking on my part. Ortho is stumped so he's referring me to a specialist. I'll see what the specialist says and if he's lost too, I guess ill try bpc, tb or one of the other promising peptides.
Mods feel free to delete or merge with Grapes link.
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I think the Ipamorelin plus CJC-1295 combo is the most popular and touted as the most potent GH releasing combo. If I'm not mistaken the Ipamorelin doesn't affect ghrelin and cortisol and some other hormones so you don't get the appetite increase.
Especially, if I thought the healing peptides had possibly injection site preferential effect I would definitely add IGF-1 DES or IGF-1LR3 or both to the "Wolverine stack" of BPC and TB. Probably a tiny dose of Fiasp insulin too to further agonize IGF receptors. Ah hell, throw the copper peptide in there too. I mean if I had the money and recovery was very important to me. It's a bit of witchcrafting because you won't find studies on a combo such as this any time soon but individually these seem probably fairly safe.
For nerve damage recovery GH does theoretically make a lot of sense to try, which is why I mentioned the IGF-1 derivatives.
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peptides
Fucking lol... ;D
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peptides
Fucking lol... ;D
I think guys like Leo Longevity, that Dr. Tony asshole, Bostin Lloyd etc give them a bad name. There's a lot of evidence supporting their recuperative/healing properties and use for treating injuries.
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I think guys like Leo Longevity, that Dr. Tony asshole, Bostin Lloyd etc give them a bad name. There's a lot of evidence supporting their recuperative/healing properties and use for treating injuries.
Injecting yourself multiple times a day/week with what is in most cases fucking sterile water
A total scam
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A few years ago, I used a combination of Ipamorelin and CJC-1295, which cured my shoulder injury. Now I use GH.
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A few years ago, I used a combination of Ipamorelin and CJC-1295, which cured my shoulder injury. Now I use GH.
What was the injury? Tear in rotator cuff?
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What was the injury? Tear in rotator cuff?
Honestly, I don't know; I've never been to a doctor about it. It wasn't severe pain, and I could train with it, but I felt discomfort during overhead presses and bench presses.
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Insofar as I know there aren't really any peptides worth taking. Use GH if you want it's effects.
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Insofar as I know there aren't really any peptides worth taking. Use GH if you want it's effects.
MK-677 works, several of us have used it for some time and posted about it.
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i'm currently recovering from shoulder reco surgery. had some very frank discussions with surgeons prior.interestingly one was 100% clear about NOT using GH in the first month or two. WEnt to the point of saying there is research that it interferes with tendons and ligaments healing early on.
I don't know the underlying mechanism,, but I'm going to wildly speculate (and may bde way way off here) that gh interferes with insulin sensitivity and as we know insulin dependant diabetics can get fucking big but threy don't heal well from cuts and the like.
so I'm using bpc157 and tb500 and currently 400mg per week of test e and 200mg of eq. I'd played around with those two before surgery and that ratio left my estrogen in a good range, so I'm sticking with it, was probably going to go higher overall but at this stage can't really see a reason to.
Anyone with more knowledge on possible reasons why gh wouldn't be great immediately post surgery ( amd to be clear in all cases on my shoulder the tendon/ligament snapped mid way, nmone of them ripped out at the bone insertion taking a piece of bone with the,m (the more ideal of tears as far as surgery and overall post surgical return to max abilitities go)
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i'm currently recovering from shoulder reco surgery. had some very frank discussions with surgeons prior.interestingly one was 100% clear about NOT using GH in the first month or two. WEnt to the point of saying there is research that it interferes with tendons and ligaments healing early on.
I don't know the underlying mechanism,, but I'm going to wildly speculate (and may bde way way off here) that gh interferes with insulin sensitivity and as we know insulin dependant diabetics can get fucking big but threy don't heal well from cuts and the like.
so I'm using bpc157 and tb500 and currently 400mg per week of test e and 200mg of eq. I'd played around with those two before surgery and that ratio left my estrogen in a good range, so I'm sticking with it, was probably going to go higher overall but at this stage can't really see a reason to.
Anyone with more knowledge on possible reasons why gh wouldn't be great immediately post surgery ( amd to be clear in all cases on my shoulder the tendon/ligament snapped mid way, nmone of them ripped out at the bone insertion taking a piece of bone with the,m (the more ideal of tears as far as surgery and overall post surgical return to max abilitities go)
GH 100% induces insulin resistance. Granted, the dosages involved with healing (ie: small) are unlikely to cause significant resistance, but it is a known side effect.
With regards to it interfering with healing, no clue. If you’re in contact with the surgeon ask them if they would be so kind as to provide you with the literature making such claims for the sake of your curiosity. I wouldn’t be surprised, if it was some kind of miracle healing agent we’d see more use of it in an off-label manner by ortho surgeons. As far as I know, none of them do.
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Insofar as I know there aren't really any peptides worth taking. Use GH if you want it's effects.
Like helping someone look better on stage the day before a bodybuilding show?
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i'm currently recovering from shoulder reco surgery. had some very frank discussions with surgeons prior.interestingly one was 100% clear about NOT using GH in the first month or two. WEnt to the point of saying there is research that it interferes with tendons and ligaments healing early on.
I don't know the underlying mechanism,, but I'm going to wildly speculate (and may bde way way off here) that gh interferes with insulin sensitivity and as we know insulin dependant diabetics can get fucking big but threy don't heal well from cuts and the like.
so I'm using bpc157 and tb500 and currently 400mg per week of test e and 200mg of eq. I'd played around with those two before surgery and that ratio left my estrogen in a good range, so I'm sticking with it, was probably going to go higher overall but at this stage can't really see a reason to.
Anyone with more knowledge on possible reasons why gh wouldn't be great immediately post surgery ( amd to be clear in all cases on my shoulder the tendon/ligament snapped mid way, nmone of them ripped out at the bone insertion taking a piece of bone with the,m (the more ideal of tears as far as surgery and overall post surgical return to max abilitities go)
2018 - Effect of recombinant human growth hormone on rotator cuff healing after arthroscopic repair: preliminary result of a multicenter, prospective, randomized, open-label blinded end point clinical exploratory trial
https://pubmed.ncbi.nlm.nih.gov/29337026/ (https://pubmed.ncbi.nlm.nih.gov/29337026/)
2013 - Human growth hormone may be detrimental when used to accelerate recovery from acute tendon-bone interface injuries
https://pubmed.ncbi.nlm.nih.gov/23636184/ (https://pubmed.ncbi.nlm.nih.gov/23636184/)
In as far as I can see (from reading into this) is that 4 - 6 weeks post surgery HGH is no bueno. After that when you get farther into the rehab, it would be much more beneficial.
The wound healing problems come more from chronic high blood sugar levels which results in poor circulation (especially in the small capillaries which are near the skin) and nerve damage.
One thing to consider is the effect of test on tendons. There is the thought that the effect of test on the muscle more so than the tendon leads to injury, but then there is some research on the improvement of collagen in a tendon causing it to become stronger. Both times I had surgery on my shoulder (rotator repair and then bicep repair) I was asked if I used test. The surgeries were 8 years apart so it seems its a common thing.
I do know it takes a lot more force to produce an avulsion fraction (tendon pulled from insertion) than a partial (or full) thickness tear. Maybe the avulsion is better due to how fast bone healing occurs but I would imagine there is still more for the surgeon to do with it.
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Injecting yourself multiple times a day/week with what is in most cases fucking sterile water
A total scam
I would think this but:
BPC-157 is currently on NADA's banned substance.
There are other peptides out there being used - insulin, etc
Big Pharma is trying to patent them.
I think there's something here.
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GH 100% induces insulin resistance. Granted, the dosages involved with healing (ie: small) are unlikely to cause significant resistance, but it is a known side effect.
With regards to it interfering with healing, no clue. If you’re in contact with the surgeon ask them if they would be so kind as to provide you with the literature making such claims for the sake of your curiosity. I wouldn’t be surprised, if it was some kind of miracle healing agent we’d see more use of it in an off-label manner by ortho surgeons. As far as I know, none of them do.
What doesn't induce insulin resistance?
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A few years ago, I used a combination of Ipamorelin and CJC-1295, which cured my shoulder injury. Now I use GH.
Placebo effect?
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MK-677 works, several of us have used it for some time and posted about it.
MK-677 isn't a peptide but for the sake of discussion let's include it. It will certainly make you fuller and most likely stronger and most get very, very hungry too. The fullness is from water retention and unfortunately plenty under the skin too.Just be wary of the insulin resistance and use a glucometer preferably. My solution is Toujeo long acting insulin and some Novorapid. Should be obvious injecting more insulin won't make you more sensitive, I think of it as a temporary protectant for the limited time you are on it.
There's one coaching clique who uses small doses of insulin before meals because they think you should be 90 or under glucose before digesting another carb heavy meal optimally. Some, I think Aceto is one, like to do a small dose say morning on an empty stomach before cardio because they believe burning off some glucose before the cardio will make the body tap into body fat easier. But insulin does stop fat burning too so there are disputes around this technique.
But almost all agree that insulin itself doesn't make you fat and you can get just as ripped with it vs without.
A little insulin resistance may help in liberating fat. The cell doesn't accept fat as easy. Think about it, very obese people lose fat at a crazy rate at the beginning of diet. Lyle McDonald said IR is a protective mechanism so we don't just get fatter and fatter.
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I asked about how this would affect a chest allograph surgery.
“ Early phase (0–6 weeks):• The graft is avascular at first and depends on host tissue ingrowth.
• Excess anabolic stimulation (like HGH) during this window can push cells into rapid proliferation before proper vascularization and collagen alignment occur.
• That’s why some studies suggest early HGH may impair tendon–bone interface healing.”
Add in some Test and some ego lifts and you have total destruction.
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one of mybrothers spends him time between UK and Dubai, India. A friend of his has a peptide company ok'ed by a few influential emiratis.
Said friend raved on and gave my brother a stack - no cost to help with joint pain hgh etc etc. his bird is an ex fitness girl so fine jabbing him.
his results.
0/10.
absolute garbage
that bad he can get them for free and doesnt bother.
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one of mybrothers spends him time between UK and Dubai, India. A friend of his has a peptide company ok'ed by a few influential emiratis.
Said friend raved on and gave my brother a stack - no cost to help with joint pain hgh etc etc. his bird is an ex fitness girl so fine jabbing him.
his results.
0/10.
absolute garbage
that bad he can get them for free and doesnt bother.
I am not all too versed on peptides but some things to consider with the 0/10 results.
1) How bad is the joint where the pain is (at some point there's nothing that will help)
2) While taking the peptides, what did your friend do to in conjunction with the peptides (i.e. laying off lifting or certain lifts, rehab, etc)
3) I think I recall that taking the peptides isn't going to give relief in two or three weeks. Sure, some people claim they feel much better but I question if they stopped doing things that aggravated the problem area
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Placebo effect?
Not really. While using these peptides, I experienced terrible numbness in my hands and wrist pain, which I didn't expect at all.
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MK-677 isn't a peptide but for the sake of discussion let's include it. It will certainly make you fuller and most likely stronger and most get very, very hungry too. The fullness is from water retention and unfortunately plenty under the skin too.Just be wary of the insulin resistance and use a glucometer preferably. My solution is Toujeo long acting insulin and some Novorapid. Should be obvious injecting more insulin won't make you more sensitive, I think of it as a temporary protectant for the limited time you are on it.
There's one coaching clique who uses small doses of insulin before meals because they think you should be 90 or under glucose before digesting another carb heavy meal optimally. Some, I think Aceto is one, like to do a small dose say morning on an empty stomach before cardio because they believe burning off some glucose before the cardio will make the body tap into body fat easier. But insulin does stop fat burning too so there are disputes around this technique.
But almost all agree that insulin itself doesn't make you fat and you can get just as ripped with it vs without.
A little insulin resistance may help in liberating fat. The cell doesn't accept fat as easy. Think about it, very obese people lose fat at a crazy rate at the beginning of diet. Lyle McDonald said IR is a protective mechanism so we don't just get fatter and fatter.
Yes, he mentioned secretagogues.
I used basically non-stop for a year (with some short breaks in between) at 20mg and then for another year, and for several months at a time after that, and didn't use any insulin. Sometimes I did use Alpha Lipoic Acid but not sure if it made any difference.
If there was any insulin resistance I think it must have been temporary as I have no issues with extra fat or getting lean after stopping longer-term MK-677.
Perhaps it doesn't push HGH and IGF-1 to high enough levels? Maybe equivalent to 2 IU's at 20-25 mg doses? Though some studies I've read says it puts the levels at about those of a 18-20 year old, and it's of course still produced by the body and not exogenous.
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Appreciate all the feedback.
Ive used MK677 from different sources and results varied from source to source. But I guess that is to be somewhat expected. One person swears by this source and another person says their order was bunk. I see that quite a bit.
I didn't like the side effects at 25 MG doses. Water, constant craving for carbs, weight gain, BP, but worst was the total inertia. Lethargic is an understatement. It was great for sleep, which I struggle with, so that was a huge benefit.
Tried it at lower doses, 12 mgs or something like that and it wasn't effective. Just slightly improved sleep.
Another question on peptides: the tablet/pill form is basically useless correct?
I see so many companies selling tablet/pill forms. But they are not orally bioavailable is my understanding.
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Appreciate all the feedback.
Ive used MK677 from different sources and results varied from source to source. But I guess that is to be somewhat expected. One person swears by this source and another person says their order was bunk. I see that quite a bit.
I didn't like the side effects at 25 MG doses. Water, constant craving for carbs, weight gain, BP, but worst was the total inertia. Lethargic is an understatement. It was great for sleep, which I struggle with, so that was a huge benefit.
Tried it at lower doses, 12 mgs or something like that and it wasn't effective. Just slightly improved sleep.
Another question on peptides: the tablet/pill form is basically useless correct?
I see so many companies selling tablet/pill forms. But they are not orally bioavailable is my understanding.
I tried BPC-157 pills and it did bupkis.
Injectable was different, based on what I posted in the other thread.
Sourcing may also be important.
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we have public health care here in aus so I won't see the surgeon again unless something goes wrong(fingers crossed and all that).
A good friend of mine had serious shoulder pain that physios and even a well known local powerlifter just couldn't make a dent on. he is perhaps the most self aware person I have ever met, you wouldn't get a placebo past him in a milliom years. Anyway, the so called wolverine stack - tb500 and bpc157 turned that around and he's even considering a powerlifting meet or two (and he certainly has the genes for it and the mindset). For them to work for him I have to believe they at least work for some. His source is direct from china. Sadly that window is closing, thanks to the fentanyl and nitazine laced pharma stuff coming in, and resultant deaths) so he will have to locally source. that roughly triples the price but let the importing be somebody else's headfuck i guess.
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Another question on peptides: the tablet/pill form is basically useless correct?
I see so many companies selling tablet/pill forms. But they are not orally bioavailable is my understanding.
They may be bioavailable to one degree or another My concern is handling of the peptide and the exact dosing when we are talking micrograms. It's not easy and I don't trust these repackaging companies. I would buy the lyophilized vials and just squirt into an empty gelcap each time. Feels logical to me ;)
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I tried BPC-157 pills and it did bupkis.
Injectable was different, based on what I posted in the other thread.
Sourcing may also be important.
I used it and my back improved.
Whether it was the BPC-157 or not, who knows, but I will be buying more in the future.
It does improve gut health so this possibly helps the immune system and the body to heal.
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What doesn't induce insulin resistance?
R-ala and berberine come to mind