Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Main Boards => Gossip & Opinions => Topic started by: shiftedShapes on July 03, 2006, 10:37:50 PM
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So when do you think we'll see Supped up myostatin BBers with 300lbs of mass and no abdominal distention.
I don't think it will be long. Imagine if it is safe???!!!!!!
we'll we see huge testing proof gene doped athletes in 2008 in Bejing?
Are some people already playing around with the stuff?
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I think there was an article floating around that debunked the whole myostatin deal...saying it was more sci-fi/bogus than anything...and that the suppliment companies were hyping it mostly for sales of their "Myostatin Blockers"...
...Div might know, he's hip to that stuff
nah it was covered in the NY times and they are currently doing human trials for application to muscular dystrophy. It is def. not BS, but you're right some sup companies were trying to capitalize on the real thing with some bogus inert powders as usual.
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Ahhhhh.. the big Mystatin craze that lasted about 2 months. Once people started using the products, they realized it was the same results for 25% more money.
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nah it was covered in the NY times and they are currently doing human trials for application to muscular dystrophy. It is def. not BS, but you're right some sup companies were trying to capitalize on the real thing with some bogus inert powders as usual.
PLEASE don't tell me you TRUST the New York Times :o
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PLEASE don't tell me you TRUST the New York Times :o
you morons are doing me a great service by bumping my thread. Please keep floating it up the board with these genius comments
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So when do you think we'll see Supped up myostatin BBers with 300lbs of mass and no abdominal distention.
I don't think it will be long. Imagine if it is safe???!!!!!!
we'll we see huge testing proof gene doped athletes in 2008 in Bejing?
Are some people already playing around with the stuff?
At some point the REAL product may become available...The fear is that experiments were done on animals about 10 years ago which produced cows, horses, mice etc that were so muscle bound that they literally could not move. In these cases a particular gene was removed from the animal which allowed uncontrolled release of Myostatin and therefore uncontrolled muscle growth. Now these animals ended up with all types of conditions that destroyed their health. For example their hearts could not keep pace with the massive muscle growth and was overwhelmed trying to supply blood to the animal even when the animal was resting.
I guess scientist will have to work on developing a secondary heart for an animal (or human) that is that big or somehow the muscles of the animal will have to play a heart like part in keeping the blood flowing. So far as a pill or injection of this drug becoming used for bodybuilding...I imagine a black market will develop at some point. I wonder however what will happen when this is used on humans. I mean other than producing massive human BB, what will be the possible health effects if any. If there are no health effects, then I imagine RONNIE COLEMAN will some day be considered VERY SMALL.
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At some point the REAL product may become available...The fear is that experiments were done on animals about 10 years ago which produced cows, horses, mice etc that were so muscle bound that they literally could not move. In these cases a particular gene was removed from the animal which allowed uncontrolled release of Myostatin and therefore uncontrolled muscle growth. Now these animals ended up with all types of conditions that destroyed their health. For example their hearts could not keep pace with the massive muscle growth and was overwhelmed trying to supply blood to the animal even when the animal was resting.
I guess scientist will have to work on developing a secondary heart for an animal (or human) that is that big or somehow the muscles of the animal will have to play a heart like part in keeping the blood flowing. So far as a pill or injection of this drug becoming used for bodybuilding...I imagine a black market will develop at some point. I wonder however what will happen when this is used on humans. I mean other than producing massive human BB, what will be the possible health effects if any. If there are no health effects, then I imagine RONNIE COLEMAN will some day be considered VERY SMALL.
I did not know that they produced myostatin inhibited horses. They must look massive. I had heard that the mighty mice were very passive and were picked on by normal mice. However, I was under the impression that the belgian blues (myostatin lacking cows) were normal functioning and healthy.
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So when do you think we'll see Supped up myostatin BBers with 300lbs of mass and no abdominal distention.
I don't think it will be long. Imagine if it is safe???!!!!!!
we'll we see huge testing proof gene doped athletes in 2008 in Bejing?
Are some people already playing around with the stuff?
Boitest and Pinnacle already have products to block it now! :-\ :P >:(
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At some point the REAL product may become available...The fear is that experiments were done on animals about 10 years ago which produced cows, horses, mice etc that were so muscle bound that they literally could not move. In these cases a particular gene was removed from the animal which allowed uncontrolled release of Myostatin and therefore uncontrolled muscle growth. Now these animals ended up with all types of conditions that destroyed their health. For example their hearts could not keep pace with the massive muscle growth and was overwhelmed trying to supply blood to the animal even when the animal was resting.
I guess scientist will have to work on developing a secondary heart for an animal (or human) that is that big or somehow the muscles of the animal will have to play a heart like part in keeping the blood flowing. So far as a pill or injection of this drug becoming used for bodybuilding...I imagine a black market will develop at some point. I wonder however what will happen when this is used on humans. I mean other than producing massive human BB, what will be the possible health effects if any. If there are no health effects, then I imagine RONNIE COLEMAN will some day be considered VERY SMALL.
the animals were breed with the gene removed. there is no injection that shuts the myostatin gene off.
a bb will need to be born with the gene removed. eugenics anyone...
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the animals were breed with the gene removed. there is no injection that shuts the myostatin gene off.
a bb will need to be born with the gene removed. eugenics anyone...
yes the animals were bred myostatin deficient but there is now a drug that turns the production off in testing for human use.
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yes the animals were bred myostatin deficient but there is now a drug that turns the production off in testing for human use.
who makes that? it would be nice to see the human trial data.
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i forget who makes it, but it is one of the biggies, and it was all over the news a few months ago. I think the companies name starts with a D but it might have been wyeth
search muscular distrophy (sp?) human trial and myostatin and you will find it
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Boitest and Pinnacle already have products to block it now! :-\ :P >:(
Snake oil - if it worked it would outsell creatine.
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Boitest and Pinnacle already have products to block it now! :-\ :P >:(
Biotest stopped making Myo whatever years ago. The results mentioned even by the Biotest asskissers on T-Nation were pretty shitty. Stuff like "After 6 months on it, I noticed a slight increase in my hamstrings". Woo. That must be the 90$ a bottle supplement you were taking that done it.
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Snake oil - if it worked it would outsell creatine.
don't insult snake oil that way, even that has some benefits. A helluva a lot more than myo blockers!
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There's no sensical way it would make any serious muscle. Remember, most of your skeletal muscle cells aren't undergoing division at any serious rate. Actually, smooth muscle cells (big blood vessles, intestines) multiply at a a much higher rate. Turning off the myostatin gene in non-dividing cells wouldn't make a lot of sense.
You could always engineer muscle babies.
Remember what PT Barnum said about a sucker being born ever minute. :)
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if any scientific studies(not involving muscletech) take place I would happily be the testing guy hehe
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I took the same stuff that was advertising the big ass cow...all i got was like a heat rash on my inner bicep area and legs...i stopped , rash left...fcuk Myostatin
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There's no sensical way it would make any serious muscle. Remember, most of your skeletal muscle cells aren't undergoing division at any serious rate. Actually, smooth muscle cells (big blood vessles, intestines) multiply at a a much higher rate. Turning off the myostatin gene in non-dividing cells wouldn't make a lot of sense.
You could always engineer muscle babies.
Remember what PT Barnum said about a sucker being born ever minute. :)
I guess you're not a medical Doctor. It turns out that people on the drug experience huge gains in muscle very quickly (I don't remember the exact amount but it was something on the order of 30% increase in lean muscle in a matter of weeks)
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There are real products out now, they have been out for about a year. Though I have not laid eyes on them, I know of a site for bodybuilders (not lab only) and it is very expensive.
anti-Myostatin
polyclonal anti-body
$2000 for 1000 mcg, don't know how they dose it
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There are real products out now, they have been out for about a year. Though I have not laid eyes on them, I know of a site for bodybuilders (not lab only) and it is very expensive.
anti-Myostatin
polyclonal anti-body
$2000 for 1000 mcg, don't know how they dose it
yeah the Luke posted a link to a site selling the stuff (didn't look like it was directed to BBers though). I can't wait to see the results.
Imagine how much BBing would change if there was a more effective safer way to get big.
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the animals were breed with the gene removed. there is no injection that shuts the myostatin gene off.
a bb will need to be born with the gene removed. eugenics anyone...
I know that the animals were bred without the gene, but there are companies working on drugs to temporarily halt the genes that regulates myostatin or temporarily halt the myostatin regulating hormones. If this "drug" is perfected, then a "CONTROLLED" muscle growth situation can be created with the potential being for people who have muscle wasting conditions...even the loss of muscle as one ages could be reduced, inhibited all together or even added to. This alone would cut down tremendously on things like falls from weakness, osteoporosis, etc which the insurance companies would love. In so much as BB goes...you know what getting a hold of that drug or product would mean.....MASS MONSTERS. I wonder if the muscle gained in this fashion would be truly permanent..unlike the steroid effect of up and down muscle loss and gain.
Anyone born with this gene removed would essentially be crippled by that action. They would never be able to engage in any activity, because even the least strenuouus activity would constantly spur uncontrolled muscle growth and soon the individual would be handicapped by his own muscles.
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I know that the animals were bred without the gene, but there are companies working on drugs to temporarily halt the genes that regulates myostatin or temporarily halt the myostatin regulating hormones. If this "drug" is perfected, then a "CONTROLLED" muscle growth situation can be created with the potential being for people who have muscle wasting conditions...even the loss of muscle as one ages could be reduced, inhibited all together or even added to. This alone would cut down tremendously on things like falls from weakness, osteoporosis, etc which the insurance companies would love. In so much as BB goes...you know what getting a hold of that drug or product would mean.....MASS MONSTERS. I wonder if the muscle gained in this fashion would be truly permanent..unlike the steroid effect of up and down muscle loss and gain.
Anyone born with this gene removed would essentially be crippled by that action. They would never be able to engage in any activity, because even the least strenuouus activity would constantly spur uncontrolled muscle growth and soon the individual would be handicapped by his own muscles.
yeah I just googled it. Wyeth is now testing a drug called MYO-029 that will shut off myostatin production. The results are due late this year. Should be interesting
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this shit was a bigger scam than vanydl sulfate. Sports nutrition customers have wised up over the years and that's why the scam died so quckly! Biotest, FOR SHAME! :(
SPIKE is the shite though. They got that one right! :)
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this shit was a bigger scam than vanydl sulfate. Sports nutrition customers have wised up over the years and that's why the scam died so quckly! Biotest, FOR SHAME! :(
SPIKE is the shite though. They got that one right! :)
some people never learn...try some caffeine pills, cheaper and just as effective
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yeah I just googled it. Wyeth is now testing a drug called MYO-029 that will shut off myostatin production. The results are due late this year. Should be interesting
Well if you hear anything on the results let us GETBIGGERS know. I find it interesting too
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Well if you hear anything on the results let us GETBIGGERS know. I find it interesting too
Yeah I'll post any results
I'm guessing though that it will make big news when they release the results.
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The problem is more than simply the gene being turned off. Let's say that the myostain gene is also in cardiac muscle too, there would be cardiomegaly as a side. If it were in smooth muscle, all the muscular layers of intestinal lumens would gow worse than gh-gut. Even then, that's not taking into account that cartilage isn't vascular and can only grow about 5% a year so there would be increased injuries. Of course it would have to be injectable with another steroid.
Is it possible to turn on/off genes? Sure. My point is turning off a gene in a stable population wouldn't necessarily cause muscle growth. Yes, it might change (shorten) the cell cycle but my guess is that no supplent company is going to make something that a lot of people would respond to.
I'd be more inclined to believe that a company was using mRNAi to shut off myostatin production. Sort of what they're doing for macular degeneration.
If something sounds too good to be true....... it probably is. :)
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There's no sensical way it would make any serious muscle. Remember, most of your skeletal muscle cells aren't undergoing division at any serious rate. Actually, smooth muscle cells (big blood vessles, intestines) multiply at a a much higher rate. Turning off the myostatin gene in non-dividing cells wouldn't make a lot of sense.
You could always engineer muscle babies.
Remember what PT Barnum said about a sucker being born ever minute. :)
Interesting info coming from a Chiropractor.
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Interesting info coming from a Chiropractor.
I'm pretty sure it was Bob Dylan who said "You don't have to be a weatherman to know which way the wind's blowin'". :)
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I'm pretty sure it was Bob Dylan who said "You don't have to be a weatherman to know which way the wind's blowin'". :)
I was referring to the first 4 sentences not the 6th. You sound knowledgable, I just wonder how correct your science is. I love my chiropractor my brother, don't get me wrong.
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yo can i gets a 20 piece?
i aint talkin about mcnuggets ;D
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I was referring to the first 4 sentences not the 6th. You sound knowledgable, I just wonder how correct your science is. I love my chiropractor my brother, don't get me wrong.
Well, it's not my science just rudimentary physiology that we're talking. It's been proven that rats, cows, babies, etc... can be engieneered ith the myostatin gene shut off. To cut off the gene, it would have to act on messenger RNA to stop Myostatin from being made or block transfer RNA's A site. On top of that it would have to produce perfect muscle cells. Theoretically, the body would produce perfect cells anyways but there's got to be a huge difference between the DNA and physiology of someone with a muscle wasting disease and your typical healthy bodybuilder. Creatine helps some people with muscle wasting too. :)
I'm a huge believer in proper nutrition and all but more along the lines of that proper nutrition can help maximize one's genetic potential.
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The problem is more than simply the gene being turned off. Let's say that the myostain gene is also in cardiac muscle too, there would be cardiomegaly as a side. If it were in smooth muscle, all the muscular layers of intestinal lumens would gow worse than gh-gut. Even then, that's not taking into account that cartilage isn't vascular and can only grow about 5% a year so there would be increased injuries. Of course it would have to be injectable with another steroid.
Is it possible to turn on/off genes? Sure. My point is turning off a gene in a stable population wouldn't necessarily cause muscle growth. Yes, it might change (shorten) the cell cycle but my guess is that no supplent company is going to make something that a lot of people would respond to.
I'd be more inclined to believe that a company was using mRNAi to shut off myostatin production. Sort of what they're doing for macular degeneration.
If something sounds too good to be true....... it probably is. :)
I don't think you will see organ enlargement in all of the Myostatin Negative animals they have found REDUCED organ size. I'm guessing it's because nutrients get diverted for use in muscle growth. But yeah I have also though about the potential for joint injury because Tendons and ligaments take a lot longer to get stronger. We will have to wait and see whether that is a problem. I'm not going to be the first person to try it, and the good thing is that when the drug does come out it will be FDA approved so we will know what the sides are, not like some fly by night supp company where you don't even know if the stuff works.
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I don't really have a solid guess about why organ size would be smalller. It's entirely possible that myostatin has a different effect on smooth muscle or something wierd like total blood volume doesn't change so there's less for organ development and the heart has to work harder.
That being said, I'll try keeping an open mind.
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IT Will Happen.
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thx for the pics hendrix!!! they look tasty
you can buy belgian blue bull meat. Obviously it's much leaner.
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some people never learn...try some caffeine pills, cheaper and just as effective
I've done that and Spike last longer without the jitters. Look, I am no fan of Biotest but when a company gets one right....
but thanks tor the advice Skippy ::)
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monster placebo effect