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1  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Doses and Gains... on: August 23, 2014, 03:54:00 AM
I see that a lot of people have used to use very big doses, don't cruise and use anabolics year round at the beginning of their "adventure" with AAS, i mean the first 3-5 years... Later more people ( gym rats and maybe only amatour/national competitiors ) lower their doses and sometimes... get better results from it than they was blasting with a lot of grams  Huh More receptors and better utilise anabolics/androgens created by high doses and long term use in the past  Huh
2  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Do AI'S hinder gains on: August 22, 2014, 11:39:15 AM
What about other one thing? I mean fat loss. High Estro can disturb fat loss or is it only about water retention?
3  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Best AAS to stay year round ( with test ) on: August 20, 2014, 06:15:30 AM
Btw...

Quote
Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E650-60. doi: 10.1152/ajpendo.00440.2010. Epub 2011 Jan 25.

17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate.

Yarrow JF1, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE.

Abstract

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.

Quote
The use of the anabolic steroid trenbolone has a long history in the bodybuilding but it has never really been considered a steroid suitable for therapeutic use in medicine. The U.S. Food and Drug Administration has not approved tren for use in humans. The media has often demonized it as a dangerous veterinarian steroid never intended for human use. However, the perception of trenbolone may soon change with the publication of a favorable study in a major scientific journal.


Joshua Yarrow and his colleagues at the University of Florida feel that trenbolone may be a viable alternative to testosterone for androgen replacement therapy. They are set to publish their study results in the February 2011 issue of the American Journal of Physiology – Endocrinology and Metabolism.

The researchers report that trenbolone enanthate may have certain advantages over testosterone that may make it an appealing treatment option for some individuals. Bodybuilders may be familiar with many of these findings.

Trenbolone is not adversely affected by the aromatase or 5-alpha reductase enzymes that metabolize testosterone into estradiol and dihydrotestosterone, respectively. Bodybuilders have enjoyed tren for years precisely because they are able to avoid steroid side effects related to estrogen and DHT.

Yarrow reports that low-dose trenbolone enanthate effectively produces anabolic effects in muscle size and partially maintains bone mineral density without causing prostate enlargement or polycythemia in castrated laboratory rats.

Supraphysiological dosages of testosterone enanthate were required to produce anabolic effects similar to low-dose trenbolone administration. However, negative side effects of prostate enlargement and elevated hemoglobin became problematic at this dose of testosterone.

Selective androgen receptor modulators (SARMs) may be the current darlings of scientific research into alternative options for androgen replacement therapy, but University of Florida researchers are excited by the “SARM-like potential” of trenbolone.

They suggest that the actions of trenbolone are similar to selective androgen receptor modulators (SARMs). Low-dose trenbolone is called “SARM-like” because of the positive anabolic effects in muscle and bone without negative side androgenic side effects of prostate enlargement or polycythemia.

Trenbolone may have benefits over testosterone in terms of androgen receptor activation, the upregulation of growth factors such as IGF-1 and fibroblast growth factor, and anticatabolic mechanisms.

Competitive bodybuilders have often preferred using trenbolone in the weeks prior to a bodybuilding competition due to its purported effects at accelerating fat loss.

The current study confirmed that trenbolone has more potent lipolytic effects on visceral adipose tissue than testosterone milligram per milligram. Furthermore, visceral fat loss increased in a dose-dependent manner with trenbolone. In other words, the more tren used, the greater the fat loss.

Trenbolone’s lack of aromatization, while generally desirable, has often been problematic for bodybuilders who have used trenbolone as the only steroid in a cycle. Therefore, most bodybuilders include an aromatizable steroid such as testosterone or Dianabol in their trenbolone steroid stacks.

Researchers also recognize that the lack of aromatization could be a potential problem if trenbolone is used alone in androgen replacement therapy. In their study, trenbolone only provided a partial bone protective effect when administered to castrated rats. The authors attribute this to the non-aromatizable nature of trenbolone.

They conclude that low-dose trenbolone enanthate treatment has SARM-like effects on muscle/fat body composition. Androgen replacement therapy with low-dose trenbolone could potentially produce anabolic gains comparable to supraphysiological testosterone treatment without the associated side effects. The therapeutic risk-benefit profile of low-dose trenbolone appears superior to supraphysiological testosterone treatment; however, additional research into this treatment option is necessary.

The researchers should be applauded for dispassionately and objectively researching the potential of trenbolone in androgen replacement therapy. Trenbolone is an anabolic steroid that has been demonized more than others due to its limited use (in pellet implants used by veterinarians to increase muscle growth in livestock). Fortunately, they looked past the political stigma associated with trenbolone to revisit a therapeutic use for an old steroid.

Special thanks to Michael Scally, M.D. for his diligence in staying on top of anabolic steroid medical research and sharing this study with MESO-Rx.

Yarrow JF et. al. 7{beta}-hydroxyestra-4,9,11-trien-3-one (Trenbolone) Exhibits Tissue Selective Anabolic Activity: Effects on Muscle, Bone, Adiposity, Hemoglobin, and Prostate. Am J Physiol Endocrinol Metab. 2011 Jan 25. [Epub ahead of print]
4  Getbig Bodybuilding Boards / UK Getbig Bodybuilding and More / Re: Ro's Road to Wabba Universe on: August 19, 2014, 09:09:10 AM
What is Your the lowest carb intake while cutting time? :-)

You know... on Getbig a lot of people ( almost everyone  Grin ) hate carbs, even while time when you want to add muscle mass but sometimes when i observe diets people who compete, i think carbs are essential.
5  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Best AAS to stay year round ( with test ) on: August 17, 2014, 11:45:07 AM
Plenty of ppl use tren year round... Just most don't know how to handle the sides or are newbs and sides are more.

Imo the longer I ran tren the less its' sides and the effects stay the same vs off. Also I never run high doses of test. I am not a fan of test at all.. I only use it for sex and nothing more nothing else. HRT or less...

You mean tren lost effectiveness after time?
6  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Best AAS to stay year round ( with test ) on: August 17, 2014, 10:21:21 AM
It's why noone use Trenbolone year round  Roll Eyes

Thanks for answers!
7  Getbig Bodybuilding Boards / UK Getbig Bodybuilding and More / Re: Simple Simons 40 day cut. on: August 17, 2014, 06:37:49 AM
What is Your calorie or P/C/F intake daily right now? +/-?  Smiley
8  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Best AAS to stay year round ( with test ) on: August 17, 2014, 06:35:39 AM
gal, no one, Disgusted, Overload, OTH or OMR ( or all of them  Grin i forgot ) said something like that "find your the best anabolic and stay with it + test as long as you can in dose which is not ruin your health and mental". Simple as fuck?  Cheesy
9  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Best AAS to stay year round ( with test ) on: August 17, 2014, 01:37:27 AM
If you stay on the same compound for X amount of months it won't have the same effect.

What do You mean? Receptors upregulating or something like that? I.e if anyone will be use 400mg EQ week for 9 months... it can stop work after few months and he will be inject "air" ( Grin ) without any benefits?
10  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Best AAS to stay year round ( with test ) on: August 16, 2014, 11:30:45 AM
Does anyone stay on test + androgen/anabolic year round in low/moderate dose? If yes, which one? And what about mgs? :-)

EQ/Deca/Master/Tren/Primo?
11  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Favourite Fat Burn Supporters on: July 23, 2014, 09:27:50 AM
How much Ephedrine, Caffeine and Aspirin in Your best ECA combo?
12  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 22, 2014, 12:31:24 AM
Right now.



13  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: need to reset on: July 18, 2014, 10:00:59 PM
Been running pretty high doses for the last 14-18 months. Usually no lower than 600 test, deca or Npp in there pretty high close to a gram and masteron to control bloat give some extra polish. Well I've stalled out I'm lethargic all the time I'm ready for a good break. I don't want to push doses higher it's a waste of money plus I really don't think I'm going to grow anymore.

I want to cold turkey for a about 4-8 weeks or however long I can make it before really looking like shit.

My weight hasn't even really gone up over this time period it's almost a waste of drugs. I think once I reset I will be able to maintain at a much lower dose.

Only problem I don't want to do it right now half way through summer. Ill stick it out until September and then go forth with my plan.

Anyone else do something like this.come to this conclusion.

So spiro, something like androgen receptor burnout or body adaptation to AAS is possible? Or You have only mental/health reasons to go down with doses?
14  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 17, 2014, 11:24:55 AM
You always need to drop cals throughout a diet, as you lose weight your caloric need decreases but if you eat the same you'll plateau since you aren't reducing your calories throughout.

But if you start with very low cals it will take a lot of time to hit plateau.

Next thing is that i think fat doesn't need calories.
15  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 17, 2014, 02:06:31 AM
Btw, OTH; you can experience something like "plateau" in lose fat with low/zero carbs or it's impossible on diet like this?

With high carbs i hitted it every one/two weeks and i needed always drop cals or add cardio.
16  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 16, 2014, 11:48:25 AM
They are correct retard if you are willing to eat clean all year round you can eat carbs and always be in good shape but since you dont have that discipline you have to go to the extreme and drop crabs.

Maybe yes.

But i think ( and what i learnt on GetBig  Grin ) it is always better to keep higher proteins, primarily with AAS.

1. High Proteins + Moderate/Low Carbs = 2200 cals
2. Moderate Proteins + High Carbs = 2200 cals

1st option will be better for muscles imo, but i can be wrong of course Smiley

This is why i hit GetBig Board; to learn here a lot.  Roll Eyes

17  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 16, 2014, 11:29:40 AM
the only thing carbs does is fill out the muscle, nothing more, you do not need to fill out your muscle during ''dieting phase'' you can if you want but the end result is the same whether you do or do not.

In my country people belive in Carbs etc. Some of bullshits which You can hear here;

1. Going under 2000 cals = 100% lose muscle,
2. The best way to cut: moderate protein, high carb, very low fat,
3. Fats are slowing your metabolism which is blocking fat loss,
4. You must go above calories maint for build muscles even with AAS,
5. You only need about ~1g proteins/lb. All above it = stored as fat or glucose,
6. T3 + Clen need a lot of carbs in diet to 100% working,
7. T3 + AAS = muscle loss,
8. CARBS ALWAYS ARE BETTER THAN FATS, FOR 90% PEOPLE.

Etc. etc.  Roll Eyes
18  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 16, 2014, 05:30:26 AM
nice, a lot less complicated, you dropped calories, seems like you made a SOLID plan here.

GOOD LUCK BROTHER, KEEP US POSTED.  Wink

Of course.

It will be my first time with less than 100g carbs. I always get advices on other BB Boards about that i need go high with Carbs when i want to keep my muscles and build new tissues ( you know something like that you need insulin and cals surplus to gain muscles ).
19  Getbig Main Boards / Gossip & Opinions / Re: 8 weeks plan to be in shape for vacation on: July 15, 2014, 09:53:55 AM
After consulted with some Guys from GetBig ( OTH, no one etc. ) my diet changed to something like diet:

1. 8oz chicken breast + 1tbsp coconut oil
2. 3 eggs whites, 2 whole eggs, 25g WPC
3. 8oz chicken breast + 0,5oz walnuts
4. 8oz chicken breast + 1tbsp coconut oil
WORKOUT + CARDIO
5. 8oz chicken breast + 1/4 cup of basmati rice
6. 1 cup of free fat cottage cheese + 2tbsp peanut butter

P: ~335g C: ~60g F: ~70g
Cals: ~2200 + veggies ( broccoli, tomatoes, green bean, cucumbers )

Training the same.

AAS changed too:

Test P 30mg ed
Tren A 50mg ed
Winny 50mg ed
T3 75mcg
Clen/ECA 2on 2off

Some simple advices which i got:

1. Keep high proteins intake
2. Max 1 meal with Carbs
3. Keep fats to have energy
4. Do it consistently and you will be shredded as fuck but if u can't be ripped with it; let's go play chess  Grin
20  Getbig Main Boards / Gossip & Opinions / Re: Macros! - Proteins, Carbs, Fats! on: July 11, 2014, 10:25:30 PM
I dont see what is bad with this topic... IF you dont want to say something from your exp than dont answer. Simple AS fuck  Wink

And its not topic about my person. Its only to discuss LOL.
21  Getbig Main Boards / Gossip & Opinions / Macros! - Proteins, Carbs, Fats! on: July 11, 2014, 12:54:39 PM
1. Is there something like eating too many Proteins? ~1,5-2g/lb is good range?

2. Are Carbs essential to muscle growth?

3. High Carbs or High Fats for fuel?

4. You best cutting/bulking/year round macros split?

What's Your opinion?  Wink
22  Getbig Main Boards / Gossip & Opinions / Re: Stupid bodybuilding shit you used to believe on: July 10, 2014, 03:25:17 AM
bullshit, lies, mistruths and other such things. oddly enough most of them are diet related w training coming a close second.

- you can't stay on tren year round.


So what about that you need to change compound after time becouse body get used to for example tren after few weeks and you won't be see any benefits?
23  Getbig Main Boards / Gossip & Opinions / Re: Stupid bodybuilding shit you used to believe on: July 08, 2014, 11:54:10 AM
tell that to Dorian Yates.

I said it as "bodybuilding shit"  Smiley
24  Getbig Main Boards / Gossip & Opinions / Re: Stupid bodybuilding shit you used to believe on: July 08, 2014, 08:48:34 AM
You must go low/zero carbs to be shredded.
25  Getbig Bodybuilding Boards / Steroids Info & Hardcore / Re: Trenbolone - the biggest myths and facts on: July 06, 2014, 07:47:53 PM
I'm with you on that man tren needs carbs otherwise you will be in a terrible mood all day and you will flatten out wayyyy to much. You can pack on the carbs when using tren and still get lean down to 7% but from there gonna take a bit more determination lolm

I also wanted to mention, that I get terrible acne coming off tren does anyone else get this? I don't get it while on, only in the couple weeks when coming off. I HAVE to shower 2-3x a day otherwise i look like I got chickenpox all over my back anntd delts0

But about how many carbs are you saying? Something like 100-150g or amazing amount like even more than 300?
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