There is a lot of misinformation and myths surrounding the growth factor peptides. Lets first take a quick refresher on what each one of these compounds do in a very simplified sense.
IGF - works synergistically with growth hormone, the majority of its profound effects on growth can be seen in children but it continues to play an important role in anabolism throughout one's life. Exogenous supplementation needs to be used in combiniation with growth hormone and most "gurus" suggest cycling it off and on while keeping gh consistent. In theory, IGF and GH can cause muscle cell hyperplasia.
MGF - actually just a variant of IGF, produced naturally in "spikes" or "pulses" following heavy resistance exercise inducing muscular damage. Its purpose to send a signal to satellite muscle cells which in turn send nuclei to the damaged muscle fibers, assisting in repair repair and over time hypertrophy.
PGF2 - PGF plays an important role in signaling the promotion of protein synthesis. It also has powerful effects of blunting fat storage.
PGE2 - related to PGF, produced naturally by the body after resistance exercis. PGE2 signals muscle satellite cell proliferation which directly translates to increased rate of hypertrophy since repairing damaged muscle fibers require mRNA production, which happens in the nucelus of the satellite cells - this entire process is being accelerated with high doses of PGE2.
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Even without much knowledge of the science behind it, one can clearly see that these four growth factors play an important role in anabolism. What makes these compounds important to professional bodybuilding is that when used correctly and in synergy with each other, growth hormone and anabolic steroids, the capacity to greatly exceed one's genetic potential can be realized.
Do the pros use these compounds? Of course. When you pay your rent and support your family by making your body as muscular as possible would you ignore four chemicals that have been proven to promote protein synthesis and muscle cell proliferation?
Remember, the physiques you see at the current top level of competition were created with much more than trenbolone and testosterone. Dont forget, the general public only caught wind of IGF-1 YEARS after it hit the pro scene and we all understand what IGF-1 and growth hormone can do...
