First shot of 5iu Kigtropin down

[QuakerOats]

Link? Source? Not doubting you I just want to read up and research more on this subject. I really never heard this before. Not even from Milos.

lol@ "not even from Milos".

[chess315]

5ius of kigs $7

[aesthetics]

Link? Source? Not doubting you I just want to read up and research more on this subject. I really never heard this before. Not even from Milos.

i can pm it to you some time later i'll have to look for it and i've just got done reading a bunch after finishing doing high rep deadlift sets so i don't feel like doing shit at the moment

want to add an addendum since while it's obvious, the way i wrote previous post might be confusing and give the wrong impression that hgh won't or can't be anabolic unless you shoot insulin, which is wrong because your body produces it's own insulin all the time. it's just that using a little bit of insulin, like 5iu humalog will increase the effectiveness of the hgh

[pellius]

lol@ "not even from Milos".

I thought Milos was god of insulina?

[pellius]

i can pm it to you some time later i'll have to look for it and i've just got done reading a bunch after finishing doing high rep deadlift sets so i don't feel like doing shit at the moment

want to add an addendum since while it's obvious, the way i wrote previous post might be confusing and give the wrong impression that hgh won't or can't be anabolic unless you shoot insulin, which is wrong because your body produces it's own insulin all the time. it's just that using a little bit of insulin, like 5iu humalog will increase the effectiveness of the hgh

No need for PM unless you have personal reasons. Post info here for all to learn from. I've found that most don't seem to know the mechanics of how insulin works in conjunction with HGH.

[dustin]

There is still a bit of mystique behind why exogenous insulin, especially used in tandem with GH causes such crazy growth. I believe it has to do with IGF-1 as well but I'm not sure by which mechanism/s it works. GH definitely primes your body for growth but something special happens when you introduce insulin.

I guess it'll probably remain a mystery for some time. I follow a lot of endocrinology and metabolism journals and news sites hoping that researchers will publish something to shed some light on it.

[farrellzach]

Tomorrow will be one week into Kigs.

Rear delt head is really starting to pop, and my appear tighter daily. Sleep is only getting better, and I could sleep all day if I wanted to, but I'm not tired at all through the day.

[aesthetics]

No need for PM unless you have personal reasons. Post info here for all to learn from. I've found that most don't seem to know the mechanics of how insulin works in conjunction with HGH.

this is a growth hormone ligand binding to the growth hormone receptor. note that it has multiple downstream actions, after binding to the GHr, it activates the JAK2, which then initiates the cascade of multiple downsteam actions.

ERK and STAT5B are two pathways of concern for GH induced anabolism, via satellite cell proliferation, and insulin modulates the effects of both. stat5b is the primary pathway in which GH induces growth, it produces IGF-1 at the local cellular level, which i'm sure everyone is aware of how significant igf-1 is for causing growth. with regard to ERK: Independent of it's role in proliferation, ERK activation has clearly been related to c-fos activation that is acutely stimulated by GH (Hodge et al., 1998) and full activation of GH-induced STAT5 signaling may also rely on ERK activation (Pircher et al., 1999) ERK itself causes proliferation, however, there is a probable direct relationship with ERK activation and STAT5B activation. the importance of insulin here is that without insulin ERK will not resensitize, and it requires both the presence of insulin while there is an absence of growth hormone for the pathway to become fully active again.

STAT5B will reactivate while there is a low level of growth hormone, within ~3 hours, however insulin itself will act directly on the STAT5B pathway to induce anabolic effects.

http://www.sciencedirect.com/science/article/pii/S0014579399016890

The STAT multigene family of transcriptional regulators conveys signals from several cytokines and growth factors upon phosphorylation by janus kinases (JAK). Activation of STAT5 is typically mediated by JAK2, but more recent data indicate a direct activation by the insulin receptor kinase. STAT5 exists in two closely homologous isoforms, STAT5a and b. We here describe the selective tyrosine phosphorylation of STAT5b in Kym-1 cells in response to insulin. Blocking insulin signalling by HNMPA-(AM)3, an insulin receptor kinase inhibitor, resulted in the loss of insulin-induced STAT5b tyrosine phosphorylation, whereas the inhibition of JAK2 by the JAK selective inhibitor tyrphostin AG490 had no effect. By contrast, in the same cells, IFNγ-induced STAT5b activation was JAK2-dependent, indicating that this signal pathway is functional in Kym-1 cells. We conclude from this rhabdomyosarcoma model that STAT5b, but not STAT5a is a direct target of the insulin receptor kinase.

furthermore, there is the issue of growth hormone receptor expression, that begins the entire process and cascade of downstream activation of pathways. growth hormone expression, and birth, is a process again modulated by insulin. with marked increases in GHR birth and expression in concordance with increases in insulin dosages, however, after ~10iu of insulin the expression of GHr becomes stymied and dosages above 10iu of insulin become counterproductive.

Insulin Regulation of Human Hepatic Growth Hormone Receptors: Divergent Effects on Biosynthesis and Surface Translocation1

Insulin modulates the biological actions of GH, but little is known about its effect on human hepatic GH receptors (GHRs). Using the human hepatoma cell line HuH7 as a model, we investigated insulin regulation of total, intracellular, and cell surface GHRs and receptor biosynthesis and turnover. Insulin up-regulated total and intracellular GHRs in a concentration-dependent manner. It increased surface GHRs in a biphasic manner, with a peak response at 10 nmol/L, and modulated GH-induced Janus kinase-2 phosphorylation in parallel with expression of surface GHRs. The abundance of GHR messenger ribonucleic acid and protein, as assessed by RT-PCR and Western analysis, respectively, markedly increased with insulin treatment. To examine whether insulin regulates GHRs at the posttranslational level, its effects on receptor surface translocation and internalization were investigated. Insulin suppressed surface translocation in a concentration-dependent manner, whereas internalization was unaffected. Moreover, insulin actions on total GHRs and surface translocation were inhibited by PD98059 and wortmannin, respectively. In conclusion, insulin regulates hepatic GHR biosynthesis and surface translocation in a reciprocal manner, with surface receptor availability the net result of the divergent effects. The divergent actions of insulin appear to be mediated by the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways, respectively.

there is very strong scientific and real world anecdotal evidence showing the synergy between HGH and insulin in inducing greater levels of anabolism. i think the key here to take away is that for optimal results from HGH usage one should incorporate small dosages of insulin, no more than 10iu at a time of novarapid injected IM, along with their hgh.

as an aside, there is a point where too much HGH can become counterproductive as well. at a certain point of over saturation, synthetic growth hormone ligands compete with one another for single growth hormone receptors, causing deactivation of the growth hormone receptor as elucidated by the following picture (second example in the figure):



so, as a conclusion, the theoretical optimal for HGH usage would be a moderate dosage of HGH, ~10iu or less, used IV (sub-cut before bed though), with usage of a fast acting insulin (novorapid is the fastest) at 7iu IM for faster clearance, two hours before the hgh is administered. obviously, steroids should be used as well but that shouldn't need to be stated.

[aesthetics]

someone tell me how to make those pictures larger i'm too lazy and tired to try to figure this out

[gh15]

what is this all explnatiosn and balonie,, just put in your blood 4 iu kigtropin and wait 30 min and see what happen,,you feel muscle pop within 30 min you are pump 3 dimention hapen within hours,, it is feeling first,, it is tighting feeling of waist,, it is imediate push of the delt from the inside out,, happen in hours! ,, pecs become full and pump,, this all happen within hours of kigtropin inject ,, ONE FUCKING INJECT,,ofcourse you dont look like ron colman on stage ,, but compare to what you were before inject ...thats the diff! you also need to be in good shape when start

the body love legit gh ,, on legit gh you will imediate post inject feel glucose fall slightly you want to drink pine apple,, you dont have to but most do eat sugar preferbly natural sugar,, then within couprl hours even within muntes you feel the emptiness that is called ANABOLIZM ,,

what is emtpiness that is called anabolizm ,, when body become anabolic the stomack empty itself fast ....and ready to take up more food,, this is what happen on legit gh ,, you become a race car....you dont thikn am i on gh ,, you know it! you become superman...you dont wait 3 months you dont wait 3 week ,, it happen on spot,, you feel the waist empty itself and ready to take whatever you give it ,, and in the same time you feel the muscles that count BLOW UP they grow in dimention ,,new surface by the fucking day

this is it friends,, then you load on the aas...to blow it up thick


and no there is no such thing as inject 10 iu for 3 week to see anything,,

fucking 4-5 iu of kigtropina you already feel diff after one damn inject,,why? LEGIT PHARM GRADE GH

gh15 approved

[aesthetics]

well, yeah, of course i didn't say not to put hgh into your blood, that was kind of the whole point, that hgh should be used lol

[purenaturalstrength]

someone tell me how to make those pictures larger i'm too lazy and tired to try to figure this out

right click on it and then left click "show image"

or

left click on it, hold the click, and drag the pic in your browser website address bar

[aesthetics]

right click on it and then left click "show image"

or

left click on it, hold the click, and drag the pic in your browser website address bar

yeah i know that, you doofus, i mean how do i make it show up bigger on the forum? or is that not possible?

[Schmoe Buster]

what is this all explnatiosn and balonie,, just put in your blood 4 iu kigtropin and wait 30 min and see what happen,,you feel muscle pop within 30 min you are pump 3 dimention hapen within hours,, it is feeling first,, it is tighting feeling of waist,, it is imediate push of the delt from the inside out,, happen in hours! ,, pecs become full and pump,, this all happen within hours of kigtropin inject ,, ONE FUCKING INJECT,,ofcourse you dont look like ron colman on stage ,, but compare to what you were before inject ...thats the diff! you also need to be in good shape when start

the body love legit gh ,, on legit gh you will imediate post inject feel glucose fall slightly you want to drink pine apple,, you dont have to but most do eat sugar preferbly natural sugar,, then within couprl hours even within muntes you feel the emptiness that is called ANABOLIZM ,,

what is emtpiness that is called anabolizm ,, when body become anabolic the stomack empty itself fast ....and ready to take up more food,, this is what happen on legit gh ,, you become a race car....you dont thikn am i on gh ,, you know it! you become superman...you dont wait 3 months you dont wait 3 week ,, it happen on spot,, you feel the waist empty itself and ready to take whatever you give it ,, and in the same time you feel the muscles that count BLOW UP they grow in dimention ,,new surface by the fucking day

this is it friends,, then you load on the aas...to blow it up thick


and no there is no such thing as inject 10 iu for 3 week to see anything,,

fucking 4-5 iu of kigtropina you already feel diff after one damn inject,,why? LEGIT PHARM GRADE GH

gh15 approved

The emptiness that kigtropin gives is crazy, i inject it, within 30 mins i feel like my stomach is a black hole it feels so empty, no matter how much i ate before

[purenaturalstrength]

yeah i know that, you doofus, i mean how do i make it show up bigger on the forum? or is that not possible?

most likely not possible, unless you turn it side ways, message boards often allow only a maximum width but not length

[farrellzach]

The emptiness that kigtropin gives is crazy, i inject it, within 30 mins i feel like my stomach is a black hole it feels so empty, no matter how much i ate before

Agreed.

It's definitely a different feeling, if I wanted to I could eat every hour on the hour. But I can also go 3-4 hours without a meal if I'm at work or something and my stomach isnt killing me, I'm just ready to eat.

[futurefreak]

Agreed.

It's definitely a different feeling, if I wanted to I could eat every hour on the hour. But I can also go 3-4 hours without a meal if I'm at work or something and my stomach isnt killing me, I'm just ready to eat.

Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.

[farrellzach]

Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.

This is a different feeling from GHRP. After a shot of that I was craving carbs. To the point I could stuff my face for an hour and be okay, but this isn't making me NEED anything. I'm just able to take in an utilize anything I eat.

[b-boy]

Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.

bwhaha ha ha ha ha... fuck bro, you inject 4iu's of kami's kigs and you will throw all that peptide bullshit in the fucking trash... now igf-des.. now that is a good peptide if used in a specific manner.. the other peptides, well if you can't afford HGH (wich i find impossible) then use what u gotta use it guess, but don't come to us asking why you can't win your state show...LOL

[gh15]

Shit, all this hunger talk is making me think the chinamen are just sending out cheapo ghrp-6 which speeds gastric emptying........ But luckily this stuff dissolves slow.

not even close to that garbage peptide,, this is legit pharm grade gh ,, the nails grow in less than 24 hours,, yuo cut them they grow GROWWWW in 24 hours,, not 5 day nto 7 day 24 hours!! grow white like a monky ,, your body renew itself very fast,,

gh15 approved

[aesthetics]

i want to try these kigs now solely to see how they compare and also because i want to see if they live up to the hype that they're that much stronger than other china gh

[farrellzach]

i want to try these kigs now solely to see how they compare and also because i want to see if they live up to the hype that they're that much stronger than other china gh

Well worth the money

[AlphaM]

what is this all explnatiosn and balonie,, just put in your blood 4 iu kigtropin and wait 30 min and see what happen,,you feel muscle pop within 30 min you are pump 3 dimention hapen within hours,, it is feeling first,, it is tighting feeling of waist,, it is imediate push of the delt from the inside out,, happen in hours! ,, pecs become full and pump,, this all happen within hours of kigtropin inject ,, ONE FUCKING INJECT,,ofcourse you dont look like ron colman on stage ,, but compare to what you were before inject ...thats the diff! you also need to be in good shape when start

the body love legit gh ,, on legit gh you will imediate post inject feel glucose fall slightly you want to drink pine apple,, you dont have to but most do eat sugar preferbly natural sugar,, then within couprl hours even within muntes you feel the emptiness that is called ANABOLIZM ,,

what is emtpiness that is called anabolizm ,, when body become anabolic the stomack empty itself fast ....and ready to take up more food,, this is what happen on legit gh ,, you become a race car....you dont thikn am i on gh ,, you know it! you become superman...you dont wait 3 months you dont wait 3 week ,, it happen on spot,, you feel the waist empty itself and ready to take whatever you give it ,, and in the same time you feel the muscles that count BLOW UP they grow in dimention ,,new surface by the fucking day

this is it friends,, then you load on the aas...to blow it up thick


and no there is no such thing as inject 10 iu for 3 week to see anything,,

fucking 4-5 iu of kigtropina you already feel diff after one damn inject,,why? LEGIT PHARM GRADE GH

gh15 approved

Very good, and for those who keep asking about nd blues (I presume I can put thanks also here) they give same exact emptiness feeling, maybe not that extreme like gh15 described above but it does! Personal experience full dinner eaten the other day, then a shot of 5iu nd blues (been on since Sep) and boooom felt like eating juicy 5 guys burger and fries together with some ice cream or chocolate in no time.

[pellius]

Very good, and for those who keep asking about nd blues (I presume I can put thanks also here) they give same exact emptiness feeling, maybe not that extreme like gh15 described above but it does! Personal experience full dinner eaten the other day, then a shot of 5iu nd blues (been on since Sep) and boooom felt like eating juicy 5 guys burger and fries together with some ice cream or chocolate in no time.

I wonder: what if you don't eat when your body is in this state of anabolism (I think that's what gh15 called it -- to lazy to scroll back) due to HGH? Do you go catabolic and actually start to lose muscle in addition to fat?