Author Topic: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV  (Read 410 times)

IroNat

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This is a new proposed mRNA version of the RSV vaccine not the current RSV vaccine being given.

mRNA vaccines come with a host of issues that can affect your immune system in a bad way.

 :-\

>

mRNA RSV Vaccine Candidate Found Effective But With Adverse Events

https://www.precisionvaccinations.com/2023/12/14/mrna-rsv-vaccine-candidate-found-effective-adverse-events

Participants in the mRNA-1345 group had a higher incidence than those in the placebo group of solicited local adverse reactions (58.7% vs. 16.2%) and systemic adverse reactions (47.7% vs. 32.9%). Most of these reactions were mild to moderate in severity and were transient.

However. serious adverse events occurred in 2.8% of the participants in each trial group.

>

mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV

Igor Chudov
Dec 15
   
 
A new mRNA vaccine is being developed: Moderna’s mRNA-1345 is a proposed immunization against RSV, one of the viruses causing colds in adults. Clinical trial results were published in the New England Journal of Medicine today.
   
   
https://www.nejm.org/doi/full/10.1056/NEJMoa2307079?query=TOC

The clinical trial’s 35,541 participants were assigned to receive the mRNA-1345 vaccine (17,793 participants) or placebo (17,748). (The placebo was saline.)

Moderna proudly reported that its RSV vaccine prevented 66 cases of RSV in 17 thousand vaccinated people. Per the appendix:

(see image below)   
   
https://www.nejm.org/doi/suppl/10.1056/NEJMoa2307079/suppl_file/nejmoa2307079_appendix.pdf

The Moderna study explains:

    Vaccine efficacy was 68.4% (95% CI, 50.9 to 79.7) against RSV-associated acute respiratory disease. Protection was observed against both RSV subtypes (A and B) and was generally consistent across subgroups defined according to age and coexisting conditions.

mRNA RSV vaccine efficacy of just 68% was relatively meager, far worse than the much-ballyhooed “95% efficacy” of COVID vaccines.

The interesting part follows:

    Participants in the mRNA-1345 group had a higher incidence than those in the placebo group of solicited local adverse reactions (58.7% vs. 16.2%) and of systemic adverse reactions (47.7% vs. 32.9%); most reactions were mild to moderate in severity and were transient.

Was taking the RSV vaccine worth it for the trial participants? Consider this: as per the above image, the vaccine prevented 66 cases of RSV among 17,793 vaccine recipients. However, it caused 5,337 more adverse events in the vaccine group than in the placebo group.
   
   

Adverse events were varied, ranging from trivial, such as minor headaches, to more disturbing ones, such as underarm lymph node swelling, fevers, vomiting, etc.

Overall, for each prevented case of RSV (remember, the vaccine prevented only 66 cases), the vaccinated subgroup suffered 5337/66 = 81 adverse events.

Let me repeat: there were 81 adverse events per each prevented case of RSV.

Is having 81 adverse events per case of RSV, essentially a mild cold, a good deal? Not to me!

What about preventing more serious illness? As per the vaccine efficacy picture below, the RSV vaccine prevented 17 cases of RSV-LRTD with >= three symptoms.
   
   

Mind you, these were not hospitalizations — merely instances of RSV with more symptoms than usual.

For example, if the patient had a 1) cough, 2) fever over 100F, and 3) sputum production, it would fit the above-underlined definition:
   
   

How many adverse events would the RSV-vaccinated study subjects have to suffer to prevent 17 such instances? The math works out to 5,337 vaccine adverse events, preventing 17 cases of RSV-LRTD with >= 3 symptoms, or 5337/17 = 313 adverse events per prevented RSV illness with at least three symptoms.

Did all 17 of the above instances involve fevers? Moderna’s study is silent on this, but let’s give them the benefit of the doubt and assume that all the above-mentioned prevented cases had a fever.

How many vaccinations resulted in vaccine-caused fevers? Page 53 helpfully provides information:
   
   

So, to prevent about 17 worse-than-usual cases of RSV involving fevers, the vaccinated subgroup had to suffer through 267 vaccine-caused fevers. Similarly, to prevent all 66 cases of RSV, avoided in the vaccinated subgroup, the vaccinees had to suffer through 267 fevers caused by the RSV vaccine.

Is that a good risk-benefit tradeoff?
Underarm Swelling

More worryingly, the mRNA RSV vaccine caused a whopping 1,620 cases of “underarm swelling” in axillary lymph nodes:
   
   

Even more disappointingly, the vaccine caused 120 long-term axillary swellings, compared to only 49 in the unvaccinated subgroup.

All of this misery and suffering, like 70 vaccine-caused long-term underarm lymph node swellings and 1,620 vaccine-caused total lymph node swellings, was imposed upon the unlucky vaccinated subgroup to prevent a measly 66 cases of RSV.
Another mRNA Vaccine Causing Immune Deficiency?

Of particular note is the fact that far more vaccinated subjects had severe “infections and infestations” up to 28 days after vaccination compared to the unvaccinated ones:
   
   

Why would mRNA-vaccinated subjects have more pneumonia and other serious illnesses?

Does all that make the proposed mRNA RSV vaccine safe and effective?

Is there a “positive risk-benefit balance”?

Will the corrupt FDA careerists rubber-stamp this ineffective mRNA vaccine, whose only benefit would be enriching Moderna’s shareholders?

ProudVirgin69

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #1 on: December 15, 2023, 05:21:49 AM »
Looks pretty efficacious to me  ???



And the existing recombinant vaccine Arexvy has similar adverse effect & efficacy profile




What’s the issue, aside from “mRNA bad!!”?

Thin Lizzy

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #2 on: December 15, 2023, 05:42:15 AM »
Even with all the propaganda and hysteria, the public has returned a verdict and has found these vaccines worthless.



https://www.cnbc.com/2023/12/13/pfizer-forecasts-2024-revenue-below-wall-street-expectations.html

A continued slowdown in demand for the company's Covid vaccine and treatment Paxlovid largely drove the weakness

falco

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #3 on: December 15, 2023, 06:07:48 AM »
Even with all the propaganda and hysteria, the public has returned a verdict and has found these vaccines worthless.



https://www.cnbc.com/2023/12/13/pfizer-forecasts-2024-revenue-below-wall-street-expectations.html

A continued slowdown in demand for the company's Covid vaccine and treatment Paxlovid largely drove the weakness

Yet, people still take the endless boosters.

Thin Lizzy

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #4 on: December 15, 2023, 06:20:42 AM »
Yet, people still take the endless boosters.

Sheep gonna sheep.

the_doc

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #5 on: December 15, 2023, 10:23:51 AM »
This is a new proposed mRNA version of the RSV vaccine not the current RSV vaccine being given.

mRNA vaccines come with a host of issues that can affect your immune system in a bad way.

 :-\

>

mRNA RSV Vaccine Candidate Found Effective But With Adverse Events

https://www.precisionvaccinations.com/2023/12/14/mrna-rsv-vaccine-candidate-found-effective-adverse-events

Participants in the mRNA-1345 group had a higher incidence than those in the placebo group of solicited local adverse reactions (58.7% vs. 16.2%) and systemic adverse reactions (47.7% vs. 32.9%). Most of these reactions were mild to moderate in severity and were transient.

However. serious adverse events occurred in 2.8% of the participants in each trial group.

>

mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV

Igor Chudov
Dec 15
   
 
A new mRNA vaccine is being developed: Moderna’s mRNA-1345 is a proposed immunization against RSV, one of the viruses causing colds in adults. Clinical trial results were published in the New England Journal of Medicine today.
   
   
https://www.nejm.org/doi/full/10.1056/NEJMoa2307079?query=TOC

The clinical trial’s 35,541 participants were assigned to receive the mRNA-1345 vaccine (17,793 participants) or placebo (17,748). (The placebo was saline.)

Moderna proudly reported that its RSV vaccine prevented 66 cases of RSV in 17 thousand vaccinated people. Per the appendix:

(see image below)   
   
https://www.nejm.org/doi/suppl/10.1056/NEJMoa2307079/suppl_file/nejmoa2307079_appendix.pdf

The Moderna study explains:

    Vaccine efficacy was 68.4% (95% CI, 50.9 to 79.7) against RSV-associated acute respiratory disease. Protection was observed against both RSV subtypes (A and B) and was generally consistent across subgroups defined according to age and coexisting conditions.

mRNA RSV vaccine efficacy of just 68% was relatively meager, far worse than the much-ballyhooed “95% efficacy” of COVID vaccines.

The interesting part follows:

    Participants in the mRNA-1345 group had a higher incidence than those in the placebo group of solicited local adverse reactions (58.7% vs. 16.2%) and of systemic adverse reactions (47.7% vs. 32.9%); most reactions were mild to moderate in severity and were transient.

Was taking the RSV vaccine worth it for the trial participants? Consider this: as per the above image, the vaccine prevented 66 cases of RSV among 17,793 vaccine recipients. However, it caused 5,337 more adverse events in the vaccine group than in the placebo group.
   
   

Adverse events were varied, ranging from trivial, such as minor headaches, to more disturbing ones, such as underarm lymph node swelling, fevers, vomiting, etc.

Overall, for each prevented case of RSV (remember, the vaccine prevented only 66 cases), the vaccinated subgroup suffered 5337/66 = 81 adverse events.

Let me repeat: there were 81 adverse events per each prevented case of RSV.

Is having 81 adverse events per case of RSV, essentially a mild cold, a good deal? Not to me!

What about preventing more serious illness? As per the vaccine efficacy picture below, the RSV vaccine prevented 17 cases of RSV-LRTD with >= three symptoms.
   
   

Mind you, these were not hospitalizations — merely instances of RSV with more symptoms than usual.

For example, if the patient had a 1) cough, 2) fever over 100F, and 3) sputum production, it would fit the above-underlined definition:
   
   

How many adverse events would the RSV-vaccinated study subjects have to suffer to prevent 17 such instances? The math works out to 5,337 vaccine adverse events, preventing 17 cases of RSV-LRTD with >= 3 symptoms, or 5337/17 = 313 adverse events per prevented RSV illness with at least three symptoms.

Did all 17 of the above instances involve fevers? Moderna’s study is silent on this, but let’s give them the benefit of the doubt and assume that all the above-mentioned prevented cases had a fever.

How many vaccinations resulted in vaccine-caused fevers? Page 53 helpfully provides information:
   
   

So, to prevent about 17 worse-than-usual cases of RSV involving fevers, the vaccinated subgroup had to suffer through 267 vaccine-caused fevers. Similarly, to prevent all 66 cases of RSV, avoided in the vaccinated subgroup, the vaccinees had to suffer through 267 fevers caused by the RSV vaccine.

Is that a good risk-benefit tradeoff?
Underarm Swelling

More worryingly, the mRNA RSV vaccine caused a whopping 1,620 cases of “underarm swelling” in axillary lymph nodes:
   
   

Even more disappointingly, the vaccine caused 120 long-term axillary swellings, compared to only 49 in the unvaccinated subgroup.

All of this misery and suffering, like 70 vaccine-caused long-term underarm lymph node swellings and 1,620 vaccine-caused total lymph node swellings, was imposed upon the unlucky vaccinated subgroup to prevent a measly 66 cases of RSV.
Another mRNA Vaccine Causing Immune Deficiency?

Of particular note is the fact that far more vaccinated subjects had severe “infections and infestations” up to 28 days after vaccination compared to the unvaccinated ones:
   
   

Why would mRNA-vaccinated subjects have more pneumonia and other serious illnesses?

Does all that make the proposed mRNA RSV vaccine safe and effective?

Is there a “positive risk-benefit balance”?

Will the corrupt FDA careerists rubber-stamp this ineffective mRNA vaccine, whose only benefit would be enriching Moderna’s shareholders?


You might have a mild learning disability and should not worry
yourself with trying to read medical journals..hope this helps
The Dude Abides

pigbuild

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #6 on: December 15, 2023, 10:35:52 AM »
i hope everyone who took the vaccine dies in 2024 or sooner

MajorDomo

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Re: New mRNA RSV Vaccine: 81 Adverse Reactions per Each Prevented Case of RSV
« Reply #7 on: December 15, 2023, 10:45:30 AM »
You might have a mild learning disability and should not worry
yourself with trying to read medical journals..hope this helps

Translation: You can't find anything factually wrong with what he wrote so you just made a catty remark like a little bitch, lol