Myostatin, how soon?

[SAMSON123]

yeah I just googled it.  Wyeth is now testing a drug called MYO-029 that will shut off myostatin production.  The results are due late this year.  Should be interesting

Well if you hear anything on the results let us GETBIGGERS know. I find it interesting too

[shiftedShapes]

Well if you hear anything on the results let us GETBIGGERS know. I find it interesting too

Yeah I'll post any results


I'm guessing though that it will make big news when they release the results.

[drkaje]

The problem is more than simply the gene being turned off. Let's say that the myostain gene is also in cardiac muscle too, there would be cardiomegaly as a side. If it were in smooth muscle, all the muscular layers of intestinal lumens would gow worse than gh-gut. Even then, that's not taking into account that cartilage isn't vascular and can only grow about 5% a year so there would be increased injuries. Of course it would have to be injectable with another steroid.

Is it possible to turn on/off genes? Sure. My point is turning off a gene in a stable population wouldn't necessarily cause muscle growth. Yes, it might change (shorten) the cell cycle but my guess is that no supplent company is going to make something that a lot of people would respond to.

I'd be more inclined to believe that a company was using mRNAi to shut off myostatin production. Sort of what they're doing for macular degeneration.

If something sounds too good to be true....... it probably is.

[Undercover Supp Guy]

There's no sensical way it would make any serious muscle. Remember, most of your skeletal muscle cells aren't undergoing division at any serious rate. Actually, smooth muscle cells (big blood vessles, intestines) multiply at a a much higher rate. Turning off the myostatin gene in non-dividing cells wouldn't make a lot of sense.

You could always engineer muscle babies.

Remember what PT Barnum said about a sucker being born ever minute.

Interesting info coming from a Chiropractor.

[drkaje]

Interesting info coming from a Chiropractor.

I'm pretty sure it was Bob Dylan who said "You don't have to be a weatherman to know which way the wind's blowin'".

[Undercover Supp Guy]

I'm pretty sure it was Bob Dylan who said "You don't have to be a weatherman to know which way the wind's blowin'".

I was referring to the first 4 sentences not the 6th.  You sound knowledgable, I just wonder how correct your science is.  I love my chiropractor my brother, don't get me wrong.

[RAT MCBAT]

yo can i gets a 20 piece?
i aint talkin about mcnuggets 

[drkaje]

I was referring to the first 4 sentences not the 6th.  You sound knowledgable, I just wonder how correct your science is.  I love my chiropractor my brother, don't get me wrong.

Well, it's not my science just rudimentary physiology that we're talking. It's been proven that rats, cows, babies, etc... can be engieneered ith the myostatin gene shut off. To cut off the gene, it would have to act on messenger RNA to stop Myostatin from being made or block transfer RNA's A site. On top of that it would have to produce   perfect muscle cells. Theoretically, the body would produce perfect cells anyways but there's got to be a huge difference between the DNA and physiology of someone with a muscle wasting disease and your typical healthy bodybuilder. Creatine helps some people with muscle wasting too.

I'm a huge believer in proper nutrition and all but more along the lines of that proper nutrition can help maximize one's genetic potential.

[shiftedShapes]

The problem is more than simply the gene being turned off. Let's say that the myostain gene is also in cardiac muscle too, there would be cardiomegaly as a side. If it were in smooth muscle, all the muscular layers of intestinal lumens would gow worse than gh-gut. Even then, that's not taking into account that cartilage isn't vascular and can only grow about 5% a year so there would be increased injuries. Of course it would have to be injectable with another steroid.

Is it possible to turn on/off genes? Sure. My point is turning off a gene in a stable population wouldn't necessarily cause muscle growth. Yes, it might change (shorten) the cell cycle but my guess is that no supplent company is going to make something that a lot of people would respond to.

I'd be more inclined to believe that a company was using mRNAi to shut off myostatin production. Sort of what they're doing for macular degeneration.

If something sounds too good to be true....... it probably is.

I don't think you will see organ enlargement in all of the Myostatin Negative animals they have found REDUCED organ size.  I'm guessing it's because nutrients get diverted for use in muscle growth.  But yeah I have also though about the potential for joint injury because Tendons and ligaments take a lot longer to get stronger.  We will have to wait and see whether that is a problem.  I'm not going to be the first person to try it, and the good thing is that when the drug does come out it will be FDA approved so we will know what the sides are, not like some fly by night supp company where you don't even know if the stuff works.

[drkaje]

I don't really have a solid guess about why organ size would be smalller. It's entirely possible that myostatin has a different effect on smooth muscle or something wierd like total blood volume doesn't change so there's less for organ development and the heart has to work harder.

That being said, I'll try keeping an open mind.

[Hendrix]

IT Will Happen.

[Hendrix]

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[Hendrix]

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[Hendrix]

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[Hendrix]

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[Hendrix]

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[shiftedShapes]

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thx for the pics hendrix!!! they look tasty

you can buy belgian blue bull meat.  Obviously it's much leaner.

[Rome]

some people never learn...try some caffeine pills, cheaper and just as effective

I've done that and Spike last longer without the jitters. Look, I am no fan of Biotest but when a company gets one right....

but thanks tor the advice Skippy

[shiftedShapes]

monster placebo effect