Is clen dangerous for the heart?

[Meso_z]

How many mcg clen do the pros take aproximately?

Doesn't it affect their heart?

Any heart side effects generally?

[Overload]

i'm not sure how much pro's take but it does place more stress on the heart. so i would take it easy on the clen use. i've only used it once and hated the way i felt on it so i've never bothered with it.

[Rimbaud]

From what I've read it can affect the heart but off the top of my head I don't remember how. You should probably be alright if you keep the doses moderate & don't get out of control.

[dr_para24]

Make sure you are getting those humus grade brands and it is well know, mcg is not easy to make them. the labs need to have a good blender to blend the raw and the block well. I have try the body designer clen. sometime it dun work at all. some time my heart beat is so fast that i feel like i m getting a heart attack. even i keep it at 80mcg per day.

[Van_Bilderass]

Some fairly new research suggests it causes apoptosis, cell death, of heart cells. This was a rat study, however the dosage used in this new study was low, similar to what a bodybuilder might use.
Ironically, clenbuterol is now investigated as a drug to strengthen the heart in congestive heart failure.

Go with Albuterol, it doesn't seem to cause heart cell apoptosis. Additionally it increases strength and also muscle size in one human study. Clen has never been shown to increase muscle growth in human trials. Albuterol should probably be as good as clen for fat loss.

[Rimbaud]

Some fairly new research suggests it causes apoptosis, cell death, of heart cells. This was a rat study, however the dosage used in this new study was low, similar to what a bodybuilder might use.Ironically, clenbuterol is now investigated as a drug to strengthen the heart in congestive heart failure.

Go with Albuterol, it doesn't seem to cause heart cell apoptosis. Additionally it increases strength and also muscle size in one human study. Clen has never been shown to increase muscle growth in human trials. Albuterol should probably be as good as clen for fat loss.

I'd like to see that study. The only reason I'm asking is because I'd be willing to bet bodybuilders use a lot more then you'd think (200mcg+). Also remember we're different from rats.

[Van_Bilderass]

I'd like to see that study. The only reason I'm asking is because I'd be willing to bet bodybuilders use a lot more then you'd think (200mcg+). Also remember we're different from rats.

Your right, were not rats. But here it is anyway:

J Appl Physiol. 2004 Dec 10; [Epub ahead of print] Related Articles, Links

{beta}2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.

Burniston JG, Tan LB, Goldspink DF.

Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

High doses of the beta2-adrenergic receptor (AR) agonist, clenbuterol, can induce necrotic myocyte death in the heart and slow-twitch skeletal muscle of the rat. However, it is not known if this agent can also induce myocyte apoptosis and whether this would occur at a lower dose than previously reported for myocyte necrosis. Male Wistar rats were given single subcutaneous injections of clenbuterol. Immunohistochemistry was used to detect myocyte specific apoptosis (detected on cryosections using a caspase 3 antibody and confirmed using annexin V, single-strand DNA labelling and TUNEL). Myocyte apoptosis was first detected at 2 h, and peaked 4 h after clenbuterol administration. The lowest dose of clenbuterol to induce cardiomyocyte apoptosis was 1 microg kg(-1), with peak apoptosis (0.35 +/- 0.005 %; P<0.05) occurring in response to 5 mg kg(-1) . In the soleus, peak apoptosis (5.8 +/- 2 %; P<0.05) was induced by the lower dose of 10 microg kg(-1). Cardiomyocyte apoptosis occurred throughout the ventricles, atria and papillary muscles. However, this damage was most abundant in the left ventricular subendocardium at a point 1.6 mm, that is, approximately one-quarter of the way from the apex towards the base. beta-AR antagonism (involving propranolol, bisoprolol or ICI 118,551) or reserpine was used to show that clenbuterol-induced myocardial apoptosis was mediated through neuromodulation of the sympathetic system and the cardiomyocyte beta1-AR, whereas in the soleus direct stimulation of the myocyte beta2-AR was involved. These data show that when administered in vivo, beta2-AR stimulation by clenbuterol is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively.

This translates to 100mcg for a 220lb person.

[Rimbaud]

Your right, were not rats. But here it is anyway:
This translates to 100mcg for a 220lb person.

Thanks.