Melanin

[Tombo]

Getting a shot of this 45 UI.... pretty pale/LCD-tanned atm, so initially im going to be shocked... but its a relatively mild dose.. wont turn black overnight, but looking forward to a good tan lawl, anyone else had any experiences with this stuff? i've only heard speculation about it, nothing backed up with evidence, and everyone i know have only spoken good things of it so yeah!

[Princess L]

Getting a shot of this 45 UI.... pretty pale/LCD-tanned atm, so initially im going to be shocked... but its a relatively mild dose.. wont turn black overnight, but looking forward to a good tan lawl, anyone else had any experiences with this stuff? i've only heard speculation about it, nothing backed up with evidence, and everyone i know have only spoken good things of it so yeah!

Are you talking about this stuff?
Melanotan

[darksol]

I have heard that stuff is hard on the liver.  Drink lots of water, and might want to take some extra B-12. 

[melanotan]

I have heard that stuff is hard on the liver.  Drink lots of water, and might want to take some extra B-12. 

Do you actually have something to support this statement or are you just passing along baseless rumor/innuendo of some clueless individual(s)?

Seriously do you even know how much of this stuff per dose it typically takes to activate melanocortin receptor in melanocytes to cause the melanogenesis (tanning) response?

We're talking miniscule amounts. 0.25 thousandths of a gram (0.25 mg).  Compare that to the kilograms of alcohol that people drink that we know for a fact is processed by the liver effectively and without nary a complaint afterwards (unless done so in a chronic fashion).

[w8m8]

Melanotan II  has been reported to cause erections / increase arousal

is that true ?

I've also read that you still need to assist with tanning in a bed or naturally to help it start the "tan" then it will keep you tan on a regular dose

is that accurate ?

[melanotan]

Melanotan II  has been reported to cause erections / increase arousal

is that true ?

I've also read that you still need to assist with tanning in a bed or naturally to help it start the "tan" then it will keep you tan on a regular dose

is that accurate ?

While is is strongly doubtful that there's any sort of hepatic problems from using melanotan I or Melanotan II, folks should still be wary about using the as of yet unlicensed melanotan peptides. None of the labs producing these peptides are regulated for their production. What this means is that there can be problems of peptides being contaminated or poorly manufactured. Folks should be doing serious, serious homework and due diligence about the peptide before ever considering using them. Do not be casual about such a thing!
In fact for the average individual I would strongly suggest waiting until Clinuvel has released melanotan one "afamelanotide" on the market. Their "suntan implant" will be highly regulated and much much safer.
Here's an excellent article that covers news of Clinuvel have received FDA approval to conduct human trials in the U.S.

http://blog.wired.com/wiredscience/2009/01/tan.html

There's a wealth of information over here too:

http://en.wikipedia.org/wiki/Melanotan (including a number of citations of FDA approved human trials)

There is a forum dedicated to this subject (from a non-BB angle though). I'd add a link but I don't want to step on this forum's toes.

Cheers

[w8m8]

K , thanks , I had already read the blog , wiki  , and browsed the forum

no definitive answers to my questions were there , .... either 



I was thinking you would answer them , I still don't understand your sudden rebuttal geared towards a suggestion of merely drinking more water and taking some extra B-12 aswell .. when you just stated this :

While is is strongly doubtful that there's any sort of hepatic problems from using melanotan I or Melanotan II, folks should still be wary about using the as of yet unlicensed melanotan peptides. None of the labs producing these peptides are regulated for their production. What this means is that there can be problems of peptides being contaminated or poorly manufactured. Folks should be doing serious, serious homework and due diligence about the peptide before ever considering using them. Do not be casual about such a thing!

[melanotan]

Well if one is taking something that is anything other than sterile there's going to be problems, there's no guarantee that what's currently available is sterile.
Taking care oneself is a given in my book. If one is intending to try out one of the peptides one should be informing oneself properly and understanding what it scientifically known about the peptides and the known side effects. If you've read that other forum then you should absolutely know without a doubt that the libido effect is very very real.
Also if you've read the Wikipedia article you would know that this libido effect
was established medically and scientifically.

Have you had a chance to watch some of the videos on Youtube:

[ Invalid YouTube link ]&aq=f

?

[w8m8]

I only saw the libido effect was there .. but still I can't see how it happens 

Is it a vascular response ? meaning is any kind of blood pressure testing involved at the time of these studies ?



I am not being beligerant , I'm really interested in how it's working once in the system .

I was also wondering if the effects were long lasting without tanning of any kind after the initial base tan , does it fade if you have less by injection or  no tanning session of some type to maintain the color you want ?

It's an interesting "product"

oh and ... no I haven't watched the videos ... yet

[melanotan]

I only saw the libido effect was there .. but still I can't see how it happens 

Is it a vascular response ? meaning is any kind of blood pressure testing involved at the time of these studies ?



I am not being beligerant , I'm really interested in how it's working once in the system .

I was also wondering if the effects were long lasting without tanning of any kind after the initial base tan , does it fade if you have less by injection or  no tanning session of some type to maintain the color you want ?

It's an interesting "product"

oh and ... no I haven't watched the videos ... yet

The libido enhancing effects of melanotan II have been primarily studied in men (for erectile and arousal dysfunction). A company called Palatin Technologies out of New Jersey bought the rights to develop melanotan II into a drug for its libido effects. Palatin took the melanotan II molecule and reworked it to negate the tanning effect and they thereby produced an additional melanocyte stimulating hormone analog that they originally called PT-141. PT-141 was further developed and human trials were conducted for sexual dysfunction (both in men & women). In anticipation of the drug being approved for human usage it was assigned the generic name, "bremelanotide". It was found to be effective up into phase II trials however there was some data generated from the phase II study that showed that in a small population (something like 1%) of trial subjects there was a reproducible blood pressure raising side effect. This hypertension issue saw Palatin's further development of bremelanotide for sexual function halted (they're still developing it however for another indication that is blood pressure related). Palatin has created another analog which they're developing under the name "PL-6983". According to their website PL-6983 doesn't appear to have the same blood pressure issue in dosages considered effective for the sexual dysfunction benefit.

Decent Wikipedia article about bremelanotide:
http://en.wikipedia.org/wiki/Bremelanotide

Here's an informative video about how bremelanotide works. You'll note in the video that they mention a drug that was for tanning, that's a reference to melanotan II:

http://abcnews.go.com/Video/playerIndex?id=2712896

The drugs work on the hypothalmus and limbic systems whereby it causes these libido / sexual effects. How they do this isn't fully understood yet.

As to your other question(s) you're going to have to work for them yourself. I've already spent too much time with this here.

[w8m8]

As to your other question(s) you're going to have to work for them yourself. I've already spent too much time with this here.

OK ,   Thanks for that then

[darksol]

I find it very suspicious that
melanotan joined getbig just for this thread, as the only 4 posts they have made have been on here.

My comments about it being hard on the liver are based on what I have read on other message boards,  hence the reason I said ( I have heard ),  I never cut down the product, I just suggested drinking some extra water and taking some extra B-12 which is a very logical thing for anything that would be hard on the liver.

I would like Melanotan to identify itself.  I smell a rat.  The rebuttle to my earlier post was a little too defensive.
Moderators please check his IP

[Princess L]

I find it very suspicious that
melanotan joined getbig just for this thread, as the only 4 posts they have made have been on here.

My comments about it being hard on the liver are based on what I have read on other message boards,  hence the reason I said ( I have heard ),  I never cut down the product, I just suggested drinking some extra water and taking some extra B-12 which is a very logical thing for anything that would be hard on the liver.

I would like Melanotan to identify itself.  I smell a rat.  The rebuttle to my earlier post was a little too defensive.
Moderators please check his IP

I believe he was here in '06 or '07 under the same name or similar talking about the same thing and never participated in any other conversations.  hmmm... interesting he's here again 

I agree with you, however, unfortunately, mods don't have IP checking power 

[mademan80]

whats wrong with a good tanning bad or spray on?

[melanotan]

I find it very suspicious that
melanotan joined getbig just for this thread, as the only 4 posts they have made have been on here.

My comments about it being hard on the liver are based on what I have read on other message boards,  hence the reason I said ( I have heard ),  I never cut down the product, I just suggested drinking some extra water and taking some extra B-12 which is a very logical thing for anything that would be hard on the liver.

I would like Melanotan to identify itself.  I smell a rat.  The rebuttle to my earlier post was a little too defensive.
Moderators please check his IP

What's almost assuredly happening here is that someone is assigning a known side effect of psoralen (PUVA) usage (ie: liver toxicity) to the melanotan peptides. From the perspective of scientific research there is nothing that has been evidenced to support any sort of toxicity to the liver.
Don't get me wrong doing things to improve one's health is advisable (again in my book this is a given) but it's just a joke when folks start assigning nonsense side-effects to a drug they are clueless about (truthiness, anyone?).

If one is going to be using performance and/or image enhancing drugs one had better be doing his or her homework and know fully what are the scientific landmarks relative to that drug before ever engaging in usage of it. Follow this game plan as much as possible before ever resorting to reliance upon some sort of rumor and/or innuendo.

[darksol]

Melanotan,
Would you mind introducing yourself.  Thus far I don't like the smell of your propaganda.  Its the kind of thing people do to build up hype on products because they have a financial interest in them.  Most of us post on various other threads about various issues relating to BBing.  You have no history on here. Although you popped up soon after a thread was started on Melanin.  The links you have been posting serve no other purpose than to push up the SEO of this thread, helping to increase your propaganda even more.  Please explain yourself.

[melanotan]

Melanotan,
Would you mind introducing yourself.  Thus far I don't like the smell of your propaganda.  Its the kind of thing people do to build up hype on products because they have a financial interest in them.  Most of us post on various other threads about various issues relating to BBing.  You have no history on here. Although you popped up soon after a thread was started on Melanin.  The links you have been posting serve no other purpose than to push up the SEO of this thread, helping to increase your propaganda even more.  Please explain yourself.

No, just been researching these peptides since the 90s. By all means delete my post (and my account if you'd prefer). I just wanted to make a point about spreading false rumors and innuendo. That point has been made and really other than helping to quash this false notion there's no need for my posts.

Thanks

[24KT]

Getting a shot of this 45 UI.... pretty pale/LCD-tanned atm, so initially im going to be shocked... but its a relatively mild dose.. wont turn black overnight, but looking forward to a good tan lawl, anyone else had any experiences with this stuff? i've only heard speculation about it, nothing backed up with evidence, and everyone i know have only spoken good things of it so yeah!

Ever considered just continuous exposure to the sun. It worked perfectly fine for my ancestors for years. 

[melanotan]

Ever considered just continuous exposure to the sun. It worked perfectly fine for my ancestors for years. 

If one is fitzpatrick skin type I or II (absolutely cannot tan - like redheads - or must burn first) this is not a viable option (particularly for skin type Is). That's part of the reason that there is this interest in the peptides is that they make it possible for these individuals to actually have a genuine melanin based tan created by the skin's pigmentation cells, melanocytes.

[Tombo]

Ever considered just continuous exposure to the sun. It worked perfectly fine for my ancestors for years. 

i burn and get freckles primarily, i'm not a redhead but im fair-skinned and don't tan very well..... never ended up getting my shot anyway  but my freinds were walking catalogues of the stuff.. some looked a little 'overdone' but most looked very good...

[Tombo]

Melanotan II  has been reported to cause erections / increase arousal

is that true ?

I've also read that you still need to assist with tanning in a bed or naturally to help it start the "tan" then it will keep you tan on a regular dose

is that accurate ?

yeah a couple of my mates said they got raging boners which wouldnt go away for hours