I'm watching the South Park episode. I was in a barber years ago and there was a guy with it and i didn't know at first. He didn't curse but would make funny ass sounds. Freaked me out...Funny on tv but that's gotta suck. 
There is a classic British documentary called "John's not mad" which followed a teenage Scottish lad around who had Tourettes. I found it hilarious watching some lad twitching and shouting random insults.
Recently, however, they did a follow up documentary on his life and it shows how badly it's effected him - he wasn't able to fulfil his dream of joining the army, never had a girlfriend, no real social life etc. I've got to admit I did feel very sorry for the dude (no sensitive).
I still laughed when he shouted "suck my dick" to his mate, though.