GH increases muscle mass which increases basal metabolic rate, and it increases insulin sensitivity as well as shutting down the inhibitory mechanisms that inhibit alpha adrenergic receptors. Terrible analogy. The fact is that caffeine almost cimpletely inhibits fat burning in low carbohydrate diets which can be verified by checking for ketones - the ketone levels which indicate fat burning are greatly reduced after ingestion of caffeine. The reason why caffeine inhibits fat burning is because is releases insulin. Your knowledge of physiology and biochemistry is sophomoric.
Your knowledge is incredibly skewed. It is amazing how a single person can be so wrong. Coffee and caffeine are not the same. Coffee has lactones and other lipophilic substances that lower the risk of diiabetes. The fact, though, is that caffeine does spike insulin in the short-term which is evident by the fact that a few hours after drinking coffee you go hypoglycemic. This is indisputable.
SUCKMYMUSCLE
Most of what you say is complete bullshit, except that coffee contains other substances which may account for the "diabetes protection".
Caffeine completely shutting down fat burning on low-carb diets - absurd and not worth to debate.
Fact of the matter is that most of the substances bodybuilders use to burn fat increase insulin resistance, yet increase fat burning. Clen, ephedrine, GH, Caffeine etc. And a result of insulin resistance is increased insulin production - yet it doesn't inhibit fat loss. And conversely, substances that increase insulin sensitivity, such as oral diabetes drugs, make people fatter.
GH by itself doesn't increase muscle, or does so very negligibly. It does not account for the increase in fat burning. Nor does GH make you more insulin sensitive.
The insulin resistance caused by GH is directly tied to the fat burning mechanism.
J Clin Endocrinol Metab. 2003 Apr;88(4):1455-63.
Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle.
Bramnert M, Segerlantz M, Laurila E, Daugaard JR, Manhem P, Groop L.
Department of Endocrinology, University Hospital, S-205 02 Malmö, Sweden. margareta.bramnert@skane.se
Comment in:
* J Clin Endocrinol Metab. 2003 Apr;88(4):1453-4.
Abstract
The effects of GH replacement therapy on energy metabolism are still uncertain, and long-term benefits of increased muscle mass are thought to outweigh short-term negative metabolic effects. This study was designed to address this issue by examining both short-term (1 wk) and long-term (6 months) effects of a low-dose (9.6 micro g/kg body weight.d) GH replacement therapy or placebo on whole-body glucose and lipid metabolism (oral glucose tolerance test and euglycemic hyperinsulinemic clamp combined with indirect calorimetry and infusion of 3-[(3)H]glucose) and on muscle composition and muscle enzymes/metabolites, as determined from biopsies obtained at the end of the clamp in 19 GH-deficient adult subjects. GH therapy resulted in impaired insulin-stimulated glucose uptake at 1 wk (-52%; P = 0.008) and 6 months (-39%; P = 0.008), which correlated with deterioration of glucose tolerance (r = -0.481; P = 0.003). The decrease in glucose uptake was associated with an increase in lipid oxidation at 1 wk (60%; P = 0.008) and 6 months (60%; P = 0.008) and a concomitant decrease in glucose oxidation. The deterioration of glucose metabolism during GH therapy also correlated with the enhanced rate of lipid oxidation (r = -0.508; P = 0.0002). In addition, there was a shift toward more glycolytic type II fibers during GH therapy. In conclusion, replacement therapy with a low-dose GH in GH-deficient adult subjects is associated with a sustained deterioration of glucose metabolism as a consequence of the lipolytic effect of GH, resulting in enhanced oxidation of lipid substrates. Also, a shift toward more insulin-resistant type II X fibers is seen in muscle. Glucose metabolism should be carefully monitored during long-term GH replacement therapy.
Block the lipolytic effect of GH and what happens?
http://jcem.endojournals.org/cgi/content/full/86/12/5813Some insulin resistance, and the resulting increase in insulin, isn't all bad from a bodybuilding standpoint. It's one reason why enhanced bodybuilders are so lean.
