Brief Exposure to Performance-Enhancing Drugs May Be Permanently 'Remembered' by

[240 is Back]

Brief Exposure to Performance-Enhancing Drugs May Be Permanently 'Remembered' by Muscles

Oct. 27, 2013 — Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a study published today [28 October] in The Journal of Physiology.
Share This:

http://www.sciencedaily.com/releases/2013/10/131027205618.htm
Previously, re-acquisition of muscle mass -- with or without steroid use -- after periods of inactivity has been attributed to motor learning. However, this new data from the University of Oslo suggests that there is a cellular 'memory mechanism' within muscle of brief steroid users.
The team investigated the effects of steroids on muscle re-acquisition in mice and discovered greater muscle mass and more myonuclei -- which are essential components for muscle fibre function -- were apparent after returning to exercise.

Professor Kristian Gundersen explains how they carried out the study and the results found: "Mice were briefly exposed to steroids which resulted in increased muscle mass and number of cell nuclei in the muscle fibres. Three months after withdrawal of the drug (approximately 15% of a mouse's life span) their muscles grew by 30% over six days following load exercise. The untreated mice grew insignificantly."

The findings might have consequences for the exclusion time of doping offenders as brief exposure to anabolic steroids might have long lasting performance-enhancing effects.

Prof Gundersen says: "The results in our mice may correspond to the effects of steroids lasting for decades in humans given the same cellular 'muscle memory' mechanism. The new results might spur a debate on the current World Anti-Doping Agency (WADA) code in which the maximum exclusion time is currently two years."
Additionally, the data suggests that strength training when young might be beneficial later in life since the ability to generate new myonuclei is impaired in the elderly.
Future studies should include human muscles and further investigation into the cellular and molecular mechanism for muscle memory.

[phreak]

So... dope young and dope hard. And don't compete until you're 22 or so, meaning you never get tested at all. Then come off and rip shit up.

[The Grim Lifter]

Suck it Croatch

[Lord Chronos]

Brief Exposure to Performance-Enhancing Drugs May Be Permanently 'Remembered' by Muscles

Oct. 27, 2013 — Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a study published today [28 October] in The Journal of Physiology.
Share This:

http://www.sciencedaily.com/releases/2013/10/131027205618.htm
Previously, re-acquisition of muscle mass -- with or without steroid use -- after periods of inactivity has been attributed to motor learning. However, this new data from the University of Oslo suggests that there is a cellular 'memory mechanism' within muscle of brief steroid users.
The team investigated the effects of steroids on muscle re-acquisition in mice and discovered greater muscle mass and more myonuclei -- which are essential components for muscle fibre function -- were apparent after returning to exercise.

Professor Kristian Gundersen explains how they carried out the study and the results found: "Mice were briefly exposed to steroids which resulted in increased muscle mass and number of cell nuclei in the muscle fibres. Three months after withdrawal of the drug (approximately 15% of a mouse's life span) their muscles grew by 30% over six days following load exercise. The untreated mice grew insignificantly."

The findings might have consequences for the exclusion time of doping offenders as brief exposure to anabolic steroids might have long lasting performance-enhancing effects.

Prof Gundersen says: "The results in our mice may correspond to the effects of steroids lasting for decades in humans given the same cellular 'muscle memory' mechanism. The new results might spur a debate on the current World Anti-Doping Agency (WADA) code in which the maximum exclusion time is currently two years."
Additionally, the data suggests that strength training when young might be beneficial later in life since the ability to generate new myonuclei is impaired in the elderly.
Future studies should include human muscles and further investigation into the cellular and molecular mechanism for muscle memory.

Good article, there has been a few other studies that have highlighted this fact. A single course of steroids, will recruit satellite cells into the muscle tissue at a rate faster that you could achieve with decades of training. Whether you are a non-responder or not will decide how much better you will look. Seen guys over the years who just did a cycle or two, they kept all their gains as they never shut them selves down.
Of course the mycoardial fibrosis and collagenesis will stay with you for life too, and most likely single use steroid users will carry around slightly compromised heart function, and higher risk if sudden death syndrome for the rest of their life too.

[tom joad]

if Croatch sees this, he won't recover.

[jon cole]

a 12/16 week cycle with perfect diet and kick ass training will change your look for ever.

[El Diablo Blanco]

The whole gh15 website is being shutdown as we type.

[chris-a]

The whole gh15 website is being shutdown as we type.

just seen i've been banned. haha! what a tragic loss to my existence. i don't even remember the last time i logged on, nonsense place...