There are at least 2 factors that require your skills (real skills not slap-fu-chingchangchong shit) to be exponentially (read impossibly in practice for 99,999%) greater than those of your antagonist:
1. You have significant physical disadvantages (height, weight, strength, speed, stamina ...) compared to your opponent
2. You use inferior methods (such as artsy fartsy shit show fu)
So, if you an elite mma fighter/boxer/kickboxer/judoka/wrestler (i said mma fighter, not fucking elite escrimador jerkoff, the oniy skills I am talking about are the ones worth a damn as in those in mma/boxing etc), faced with a random loser, you may have sufficient skill disparity to pull off some real chacky Chan moves. But why would you considering you could just end his life with a single shot
Now let's come back down to earth.... and talk about "real world self defense" purposes....
Is it realistic that someone who stands absolutely no chance of taking you out would randomly attack you (unarmed)?
No
Who would more likely if ever?
Someone with a good chance or better of fucking you up bigly
The final and only answer to this all?
Carry a gun and practice shooting and drawing it a lot and under stress
Good luck (to retards who would argue anything in this post because it's all facts)