He has a super giant head. What's the deal, gh? That pic someone posted of him with his family, none of the kids have the somewhat deformed look Lou has.
IIRC, when Lou made his big come-back via the WBF he ended up giving himself Carpal Tunnel Syndrome, a well known GH side (Bev Francis encountered a similar problem). Of course, these may have been entirely unrelated to GH use, so I suppose I'm being mean spirited for bringing it up?

Having said that, since all human attributes can be said to be distributed statistically via a bell curve, it's not unreasonable to expect that some people - some as Lou - may be at the upper end of endogenous GH production. Not Andre the Giant territory, but much higher than the general population... So the introduction of GH to such an individual might 'tip their balance' much more quickly than a dude with low natural levels. (Hoping a GetBig expert chimes in here)
(Full disclosure: Big Lou fan here - some of the most balanced arms of all time IMHO)