Aside from the hypoglycemia factor, why is this reserved as a "last resort"? Elitism. That's what.
I know a 6 year old who administrators her own insulin all day, everyday. Sometimes pros spark BS esoteric gym lore because their afraid to let their secrets out. Its like how people covet tren as a miracle steroid that only the vets should use. I do advocate taking baby steps, but I don't need less intelligent, more hardcore druggies try telling me the proper way to abuse drugs.
If these dumb fucks want to get bent out of shape because the sheep wont listen to the shepherd, too fucking bad! The same rules apply whether you're a tiny tit or a maxed out beast. The only difference is the volume of drugs and the insecurities of juice heads. Drives the insecure crazy.
I say use whatever. Using small amounts of multiple drugs can be safer as long as you're experienced with whatever substance you're using. You should be smart enough to run it all if you're running ANYTHING at all.