Diet plays a huge role in plaque build up. I know two guys who have been using for almost 20 years each. Both these guys almost never take a break. Both of them do not use any other type of drugs or stimulants nor have they ever drank alcohol. I finally got on of them to get their arteries checked for blockage. Turns out he has one artery that is 5% blocked and the rest are totally clear. This is actually better than most of the population his age.