My endocrinologist , told me that's a ludicrous amount to take, and 100 mcg was assisnine. anything above 25 mcg could cause a stroke or heart attack, and prescribes people 7.5 mcg to 12 mcg T3 or less even but would never do 25 mcg .... He's not a body builder .. and i assume he's over reacting .. but he did go to medical school, and i do value his opinion... just passing on the information...