I like the study below mostly because I get a laugh about scientists making rats do the rat stroke for science...
http://www.ncbi.nlm.nih.gov/pubmed/23295603The effects of exercise modalities on adiposity in obese rats.Speretta GF, Rosante MC, Duarte FO, Leite RD, Lino AD, Andre RA, Silvestre JG, Araujo HS, Duarte AC.
Source
Laboratory of Nutrition and Metabolism Applied to Exercise, Department of Physical Education, Center of Biological and Health Sciences, Federal University of São Carlos, São Carlos, SP, Brazil.
Abstract
OBJECTIVE:
The aim of the present study was to evaluate the effect of both swimming and resistance training on tumor necrosis factor-alpha and interleukin-10 expression, adipocyte area and lipid profiles in rats fed a high-fat diet.
METHODS:
The study was conducted over an eight-week period on Wistar adult rats, who were divided into six groups as follows (n = 10 per group): sedentary chow diet, sedentary high-fat diet, swimming plus chow diet, swimming plus high-fat diet, resistance training plus chow diet, and resistance training plus high-fat diet. Rats in the resistance training groups climbed a vertical ladder with weights on their tails once every three days. The swimming groups swam for 60 minutes/day, five days/week.
RESULTS:
The high-fat diet groups had higher body weights, a greater amount of adipose tissue, and higher tumor necrosis factor-alpha expression in the visceral adipose tissue. Furthermore, the high-fat diet promoted a negative change in the lipid profile. In the resistance training high-fat group, the tumor necrosis factor-alpha expression was lower than that in the swimming high-fat and sedentary high-fat groups. Moreover, smaller visceral and retroperitoneal adipocyte areas were found in the resistance training high-fat group than in the sedentary high-fat group. In the swimming high-fat group, the tumor necrosis factor-alpha expression was lower and the epididymal and retroperitoneal adipocyte areas were smaller compared with the sedentary high-fat group.
CONCLUSION:
The results showed that both exercise modalities improved the lipid profile, adiposity and obesity-associated inflammation in rats, suggesting their use as an alternative to control the deleterious effects of a high-fat diet in humans.
