Does the human body adapt to alcohol?

[wolfrittner]

Isn't that the point were Shizzo comes in to explain?

[DroppingPlates]

The same as with junkfood and cigs, they get slowly sick...

[CalvinH]

Yes, when I was younger I could drink for days and function....now that I've really slowed down my drinking three or four drinks hurts the next day.

[Natural Man]

balance... extremes are bad...

[Mr Anabolic]

Yes it fully adapts to alcohol...



It called death.

[CT_Muscle]

The same way it adapts to bodybuilding?

How the hell do some of these assholes drink a dozen drinks and not get sick?

Microsomal ethanol oxidizing system

The microsomal ethanol oxidizing system (MEOS) is an alternate pathway of ethanol metabolism that occurs in the microsome in the oxidation of ethanol to acetaldehyde. While playing only a minor role in ethanol metabolism in average individuals, MEOS activity increases after chronic alcohol consumption. The MEOS pathway requires the CYP2E1 enzyme, part of the cytochrome P450 family of enzymes, to convert ethanol to acetaldehyde. Ethanol’s affinity for CYP2E1 is higher than its affinity for alcohol dehydrogenase. It has delayed activity in non-chronic alcohol consumption states as increase in MEOS activity is correlated with an increase in production of CYP2E1, seen most conclusively in alcohol dehydrogenase negative deer mice.[1]
 
The MEOS pathway converts ethanol to acetaldehyde by way of a redox reaction. In this reaction, ethanol is oxidized (losing two hydrogens) and NADP+ is reduced (by accepting hydrogen) to form NADPH. This process consumes ATP and dissipates heat, thus leading to the hypothesis that long term drinkers see an increase in resting energy expenditure.[2]

[falco]

Off course it adapts. When i was younger if i drank 3 beers i would be totally drunk.
Now it's like drinkig water. If i stop drinking for some months when i start i get drunk a lot easier.

[ESFitness]

The need to change "the state" (emotional/psyshological) is usualy a real problem, not the alcohol or Nubain..

yea, I figured that out

[calfzilla]

Next time please direct all alcohol related questions to shizzo.

[polychronopolous]

Interesting, makes sense.

Now that you say it, I think I've actually noticed that in people over the years.

When I saw that you replied I thought for sure it was "When you've been drinking as long as I have you build a tolerance" or "We all gotta work in the morning", or "Don't be a pussy Vaugn"

 

"You ain't drunk driving are ya, Doyle?"

"Yeah pretty much"

Not sure if you were aware of that part. It's only seen in the extended version.  

[Roger Bacon]

"You ain't drunk driving are ya, Doyle?"

"Yeah pretty much"

Not sure if you were aware of that part. It's only seen in the extended version.  

haha yes!! I love that

That's the part where he says "Not that you two afflicted sumbitches know anything about this, you're sitting in a crew-cab duallie pickup. In some circles, this is considered a piece of automotive art."

Fucking brilliant, I've heard legit rednecks say stuff just like that!!!!!!!!!!!!!!!!!!!!! 

[_bruce_]

Yes. Slowly build up and focus on the task at hand. Epic times and family feuds ahead! I always order my wife and children to wear protective gear when I'm on a strong Rumbolone cycle.

[Lustral]

There is a Celtic gene that allows for higher alcohol intake. Our ancestors used to get blind drunk for more than a thousand years.

Then there is increased tolerance. I drink 3 bottles of wine and 2-4 cans just to feel drowsy, could easily take 30 drinks between beers and shots on a night out. Sad really but it is what it is.

[Marty Champions]

The same way it adapts to bodybuilding?

How the hell do some of these assholes drink a dozen drinks and not get sick?

they do nothing thats why. nothingness helps the body to recover , and they sleep like bitches

[Marty Champions]

alcohol sucks ive experimented with it enough, its too dangerous

[dr.chimps]

alcohol sucks ive experimented with it enough, its too dangerous

Agreed. Eye protection, and safety gloves recommended.

[Roger Bacon]

I could never become an alcoholic because my desire to save money overrides my urge to drink. 

$7.95 for a drink? Are people infuckingsane?

Do I look like a fucking schmuck?

[BIG AL MCKECHNIE]

Some seem to be able to function partly drunk for years.
Read Larry Hagman's autobiography. He started with a large vodka every morning and got thru 3-4 bottles of Champaign steadily all day from the 70's to the 90's. He wasn't sober for a minute in 20 years.  Every scene in Dallas he was slightly in the zone but never actually got drunk.

Downside is the needed a new liver eventually. And is now dead.

He is the very definition of the functioning alcoholic and of course people always thought he was sober because they had never actually seen him anything other than part drunk.