can you explain why tren is particually hard on the kidneys ? i was always under the impression steroids/test damage your kidneys from high blood pressurre not the actual chemical compound its self
on another not i used to be a heavy drinker till i did 2 tren cycles ten years ago 2 summers back to back and i havent been able to handle my booze since
The kidney tox is theoretical, based on a lot of anecdotes. Some say there's zero evidence it's worse than other gear but I'm not so sure. There has been research saying androgens in general are detrimental in general for the kidneys but I still think it has mostly to do with BP. One member here did attribute his kidney failure to decades of tren use. Tren does have very high affinity for androgen receptors, like 3x that of testosterone. Llewellyn said tren is 5x as anabolic as well as androgenic as test but apparently he pulled it out of his ass. It could be said to be LESS androgenic that test in fact, depending on how you look at it. And like I've said, most all anabolics were developed to reduce the androgenic vs anabolic effects, that's literally why they"re called
anabolic steroids. Testosterone is actually called an androgen, like they say "testosterone
and anabolic steroids." But of course test can also be called an anabolic steroid too. Researchers actually call tren a steroidal SARM.
17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate
Joshua F Yarrow et al. Am J Physiol Endocrinol Metab. 2011 Apr.
Abstract
Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have 
because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens.[they are referring to DHT here. androgenicity is limited] We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. [less androgenicity and less sides] Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.
PubMed Disclaimer
In animals, androgenicity is measured by a steroid's effect on the prostate. Anabolism is measured by the growh of the
levator ani muscle. Though this type of measurement might have questionable transferability to human use. But that's where the "anabolic contra androgenic indices" come from.
So at least on paper they theorise tren would produce less sides than test. The mental effects may not be due to "high androgen" per se, could have to do with the cortisol blocking effects or whatever.
I also have to say though, in practise in high doses, tren can swell up the prostate more than anything else, though I've also ran test in liberal amounts with it. One "guru" says this is imaginary but I don't think so.
