Regular DHEA probably won't burn much fat in most people, although in women it will elevate their testostrone levels a bit which could impart a harder look (and increased sex drive). There is a metabolite of DHEA called 7-keto-Dhea which has some studies showing it improves thyroid function and suposedly burns fat a bit. It does not convert to Testosterone or estrogen. It is sold alone or sometimes is included in fat loss formul;as
I should be more specific. I am fairly certain it's the 7-keto-Dhea that is in the NITOR and Third Degree Burn. I don't have the bottle with me, but I'll double check.
One of the most important of these is 7-Keto DHEA (commonly referred to as 7-Keto), a hormone metabolite that can safely boost immune function and help reduce body fat. Unlike DHEA, however, 7-Keto does not convert to estrogen and testosterone. Because DHEA and 7-Keto have separate and unique functions and properties, it is important to understand the differences between these two popular dietary supplements.
Studies have demonstrated that 7-Keto does not accumulate in the body over time and is free of unhealthy side effects. An analysis of the metabolite at the Chicago Center for Clinical Research found that 7-Keto is rapidly absorbed and sulfated, much like DHEA. The sulfated form of 7-Keto DHEA is more stable in plasma, and blood levels can therefore be more accurately measured with laboratory equipment. In the Chicago analysis, peak plasma levels were achieved 2.2 hours after supplementation, and a steady-state level in plasma was reached with twice-daily dosing. Despite 7-Keto DHEA’s rapid elimination by the body, measured as a half-life of 2.17 hours, relatively high blood levels are quickly achieved. For example, after one week of dosing at 200 mg per day, a mean 7-Keto level of 15.8 nanograms per milliliter (ng/ml) was attained; after four weeks of supplementation, the mean level was only modestly higher at 16.3 ng/ml. Supplementation with 7-Keto can therefore have relatively rapid benefits. Lower dosing resulted in proportionally lower blood levels of 7-Keto
7-Keto produces fat loss through the process of thermogenesis. This term refers to the creation of heat, which is one of the forms of energy produced when the body’s cells metabolize the food we eat. Greater amounts of thermogenesis boost the body’s metabolic rate which increases the conversion of stored fat into energy.
7-Keto enhances the activity of three thermogenic enzymes that stimulate fatty acid oxidation in the liver. These thermogenic-en-hancing enzymes are fatty acyl CoA oxidase, malic enzyme, and glycerol-3-phosphate dehydrogenase. These enzymes drive the liver cells to burn fatty acids for energy, which causes a lowering of triglycerides in the liver.
Supplementation with 7-Keto has a dramatic effect on boosting levels of these thermogenic-enhancing enzymes. Studies found that fatty acyl CoA oxidase increased by 128%, while malic enzyme jumped 860%. The concentration of glycerol-3-phosphate dehydrogenase increased by 138% as well.
A study published in Current Therapeutic Research revealed just how effective 7-Keto is in inducing fat loss.13 In this randomized, double-blind, placebo-controlled study, 30 overweight adults (28 women and 2 men) were divided into two groups. Group 1 received 100 mg of 7-Keto twice daily for eight weeks, while group 2 took a matching pla-cebo capsule. All subjects participated in an exercise program three times a week that consisted of 50 minutes of aerobic and non-aerobic cross training under the supervision of an exercise physiologist. In addition, each subject was instructed by a registered dietitian to follow an 1800-calorie-a-day diet. The subjects underwent testing for blood chemistry, body composition, blood pressure, and dietary analysis at baseline and at weeks four and eight.
The researchers found that the 7-Keto group lost a significant amount of body weight compared to the placebo group—6.3 versus 2.1 pounds. The 7-Keto group also lost a greater percentage of body fat compared to the placebo group—1.8% versus 0.57%. Compared to the placebo group, the 7-Keto group saw a significant increase in thyroid hormone activity that targets fat- burning genes in the mitochondria and adipose tissue. No adverse effects were reported. The results show that 7-Keto can significantly and safely reduce body weight and body fat when combined with exercise and a reduced-calorie diet. This is due to the greatly increased levels of fat-burning enzymes in the liver as well as the elevation of thyroid hormone. These beneficial changes are known to boost basal metabolic rate, making it easier to shed excess pounds. Supplementation with 7-Keto can therefore help reverse the decline in metabolic rate that makes it so easy to put on weight as we age. Unlike caffeine and ephedrine, 7-Keto does not have a central nervous system stimulating effect caused by nor-adrenalin release, nor does 7-Keto increase heart rate or blood pressure.