DNP is seriously dangerous stuff, and nothing to be taken lightly. If you ask me, you have to be an idiot for even thinking of using it with so many other viable options for weight loss on the market, or even the black market.
Commercial DNP is primarily used for making dyes, other organic chemicals, and wood preservatives. It is also used to make photographic developer, explosives, and insect control substances. DNP is sold under many trade names, some are Caswell No. 392®, Sulfo Black B®, and Nitro Kleenup®. You can also find it in Raid, Black Flag and Semtex. Starting to understand?
Contrary to popular belief, DNP is illegal in almost every country, even thise where anabolic steroids are legal.
Pharmacological action
In living cells, DNP acts as a proton ionophore, an agent that can shuttle protons (hydrogen ions) across biological membranes. It defeats the proton gradient across mitochondria and chloroplast membranes, collapsing the proton motive force that the cell uses to produce most of its ATP chemical energy. In other words, instead of producing ATP, the energy of the proton is lost as heat. Cells conteract the lowered yields of ATP by oxidising more stored reserves such as carbohydrates and fat, which is why it causes such fat loss. The down side is that a lower production of ATP causes a host of unwelcome side effects.
Environmental toxicity
DNP is considered an important environmental contaminant by the United States Environmental Protection Agency. It has been found in 961 of 1400 priority sites that need clean-up of industrial waste. It can enter the air from automobile exhaust, burning of certain industrial substances, and from reaction of nitrogen in air with other atmospheric chemicals. The major site of degradation is the soil, where microorganisms metabolize it, pollution of groundwater and poisoning of animals that come in contact with it.
Use as dieting aid
DNP was used in the 1930s in diet pills, since it speeds the metabolizing of carbohydrates and fats, the user losing the energy as heat and causing dramatic weight loss over a relatively short time. However, early concerns about dangerous side-effects and potentially lethal overdose resulted in it being banned in the United States in 1938. DNP, however, continues to be illicitly used by some bodybuilders and others to rapidly lose body fat, and fatal overdoses are still reported by those who don't know of its downsides.
Side effects in persons using DNP as a dietary supplement
Heat- The production of heat will increase in proportion to the dose. Body temperature will only increase when the user reaches a threshold level where additional heat cannot be dissipated. At some doses, profuse sweating is not uncommon. This increase in core body temperature causes a vasodilation effect throughout the body to promote cooling. Dehydration can cause the body to not regulate temperature properly and rapidly overheat as well. Drink water liberally.
Insomnia- sleeping will be very difficult for some subjects, not because of the familiar central nervous stimulation experienced with ephedrine and caffeine supplementation, but because of heat. Many users find it very difficult to sleep when sweating profusely. The best way to combat this is to lower the dose or use external cooling agents (e.g. fans, air conditioner, ice pack in pillow)
Water retention- this is very closely associated with heat. When the vasodilation occurs due to the rise in body temperature, blood vessels expand, causing an increase in blood volume and subsequent water retention. Also, an increased blood volume leads to decreased pressure, which would lead the body to try to store more sodium and cause even more water retention. All the water retention will subside within approximately a week after stopping the DNP dosage, but often sooner than that. Popular diuretics are not recommended against DNP induced water retention. While diuretics will get rid of some stored water, it would put the user in jeopardy of serious health complications due to potassium depletion.
Lethargy- Dinitrophenol impairs the production of the ATP that is required for energy. The extent of the lethargy will depend on the dose. At very high doses, lethargy can be extreme. At low doses, it may not be noticable at all. Lethargy subsides within 24-36 hours of discontinuing use.
Shortness of breath/ rapid breathing- this is another common side effect, especially in higher doses. Breathing displayed in subjects is sometimes comparable to light-to-moderate aerobic excercise, even at rest. Subjects may show difficulty in catching breath.
Dehydration- If hydration levels are not adequate it can predispose the body to severe overheating and death. Water needs to be replenished liberally.
Headache- largely due to dehydration. In most subjects, forcing down a liter of fluids will alleviate the headaches
[
b]Dry/sore throat
Chapped lips
Dry skin [/b]
Electrolyte depletion- Caused by excessive water and salt loss through sweating. Drinking water will replace fluids, but not electrolytes. This can lead to a host of other side-effects if not remedied including (but not limited to):
excessive lethargy
low blood pressure
poor cardiac function
nausea
diarrhea
Nausea- This is a common side effect that affects approximately 30% of users. There could be several nauseating factors: dehydration, electrolyte imbalance, low blood pH, and other unknown body mechanisms, such as allergic reaction
Diarrhea - Due to electrolyte imbalance and/or undissolved DNP that passes onto the large intestine causing osmotic imbalances. If this becomes problematic the user must either decrease the dosage or stop completely, as this also leads to dehydration
Allergies/dermatitis- Relatively rare, and seen in less than 10% of subjects. The allergy manifests first as phantom itches (itching without any rashes or redness) around the torso in some people. It later develops into rashes and or hives around the body and possibly spread to the face, neck, lips, and scalp area in severe cases. Over the counter or prescription allergy medication (anti-histamines) should remedy allergy symptoms but allergic subjects should halt use immediately. Subjects allergic to DNP have been known to show less severe reaction to future doses. It first gets worse, then better with successive cycles. Allergic subjects should stop use immediately and start again 7-10 days later; this can be repeated as necessary until no allergic reaction occurs. Allergies are also dose and length relative.
Cataracts - While taking DNP, approximately 0.1% of women (including younger women) reported rapidly developing and irreversible cataracts. This was the primary cause for the ban of the drug. Ensuring adequate antioxidant intake will help prevent cataractogenesis.
Coloration of Bodily Fluids - Fairly common, especially in subjects who do not hydrate properly. Yellow tinged sweat, saliva, and semen, and intensely (but not bright as with high concentration of vitamins) colored urine are commonplace.
Get a clue, people. Leave this stuff alone
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