there are already thousands of variants, last count was 4,000, that was last year...
Delta is the beginning of the end for the vaccine. Or the beginning of the beginning for the variant/ booster shot footrace that's bound to ensue. Your UK alpha variant showed a little promise but the injuns out did you.
It's pretty well demonstrated that the unvaxed are better producers of mutations (at this stage), but since only the vaxed select for breakthrough, they will be driving the evolution of vax avoidant strains.
The bacteria/ antibiotic resistant varieties parallel is hard to miss. Who made them antibiotic resistant? All the people not taking antibiotics?
With something so mutable, ADE looks like a matter of time imho.